Abstract: A system of light emitting diodes and lightguides can produce and distribute light in a luminaire. Two or more lightguides can be mounted adjacent one another so that their edges extend alongside one another. An optic can couple light between the light emitting diodes and the edges of the adjacent lightguides. The optic, which can be another lightguide in some examples, can mix, blend, or homogenize light received from the light emitting diodes and distribute the light among the adjacent lightguides. The optic can mix light emitted from multiple light emitting diodes so that light enters the adjacent lightguides uniformly along the edges of the lightguide, thereby eliminating or reducing any bright spots or visual inconsistencies. The optic can further allocate light uniformly among the adjacent lightguides.

Abstract: Described include various embodiments of an integrated multi-level network appliance and system, and remote management system and method therefor. In one embodiment, the appliance can comprise: two or more hardware-integrated processing engines each operable to implement a corresponding network-related resource associated with a respective network level in accordance with a designated multi-level network architecture; an integrated processor operable to execute the processing engines; one or more integrated data storage resources accessible to the processing engines to implement each corresponding network-related resource; and a trusted single-chip switch having a plurality of hardware ports associated therewith and configured to define in hardware multiple data communication paths embedded therein.

Abstract: Described are various embodiments of a hardware security module. For example, in one embodiment, a hardware security module is described to comprise: two or more hardware ports, each one of which operable to electronically receive given input hardware port-specific cryptographic data thereon to initiate execution of an internal cryptographic process as a function thereof; two or more segregated hardware port-specific storage spaces each operatively linked to a corresponding one of said hardware ports via a corresponding hardware link, and storing respective secured hardware port-specific cryptographic data thereon exclusively retrievable as a function of said given input hardware port-specific cryptographic data corresponding thereto; and a cryptographic engine operable to execute said cryptographic process based on said secured port-specific cryptographic data retrieved from said segregated hardware port-specific storage spaces as a function of said given input port-specific cryptographic data.

Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.

Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A tilt-sensing apparatus for a vehicle, comprising: a controller; and a motion tracker, wherein the controller is configured for communication with the motion tracker and a display, wherein the motion tracker is configured for attachment to a vehicle at a position remote to the display and comprises a first tilt sensor configured to measure a first tilt angle with respect to a first axis and a second tilt sensor configured to measure a second tilt angle with respect to a second axis, wherein the controller is configured to receive data via an output of the motion tracker, said data comprising the first tilt angle and the second tilt angle, and communicate an instruction to the display to display a graphical representation indicative of the first tilt angle and the second tilt angle, and associated method.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A multisensory learning system incorporates a plurality of connectable multisensory elements. Each multisensory element may be a piece, a tile, or a block, and includes a surface containing a single character recessed into the surface to form a track. The track may guide a user's finger into the recessed area containing a tactile pattern at a base thereof. The tactile pattern heightens the sensory perception of the character to aid in learning. Each multisensory element is capable of being attached to another multisensory element in order to string characters together. In use, tracing of the tactile pattern of the character triggers the combination of sensations of kinesthetic learning through the motion of tracing and tactile learning through the feel of the tactile pattern in the recessed characters. This may be combined with audiovisual learning by looking at the character(s) and speaking the name.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A cap adapted to cover an end of a cask for maturation of a spirit, comprises a body having an outer plate and a flange extending from the outer plate, and an inner plate spaced from the outer plate. The inner plate lies between the outer plate and the end of the cask when the cap is in place on the end of the cask. A layered or ridged spacer can separate the plates, and can permit fluid transfer in the space between the plates. The inner plate can be resistant to vapor transfer, and can be pressed against the outer surface of the end of the cask when the cap is in place on the end of the cask, and leaves an annular area of the end of the cask uncovered.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A member has a wave inhibitor adapted to control the effects of a wave of longitudinally displaced material positioned ahead of an expansion mandrel used to expand the member. The wave inhibitor has a decreasing transverse cross-sectional area to diminish the effects attributable to the wave, such as workpiece distortions, material upset of the workpiece, lengthening of the member, and excessively high strains in the workpiece. The wave inhibitor can also induce radially compressive stresses in the workpiece and produce an interference fit.

Abstract: A method of peritoneal removal of electrolytes and inflammatory mediators. The method begins with infusing a treatment solution into the peritoneal cavity of a patient by way of a catheter. The treatment solution is drained from the peritoneal cavity by way of the catheter. During the draining, the treatment solution is filtered for removing electrolytes and inflammatory mediators.