Abstract: Systems and methods are described, which provides electrical stimulation to a person, while also facilitating delivery of a drug through the system to a target region of the brain. The electrical stimulation to the target region of the brain increases a permeability of a blood brain barrier.

Abstract: A composite tube comprising a region of greater diameter forming a bellow. The bellow has a first side and a second side spaced apart in the axial direction of the tube. Each side of the bellow comprises at least one hole and the at least one hole on the first side is offset in relation to the at least one hole on the second side. The holes in the bellow provide increased flexibility, thereby allowing a greater amount of bending or articulation in the shaft. The holes reduce the amount of material in the sides of the bellow, thereby reducing the material stiffness and thereby increasing the flexibility.

Abstract: Embodiments are directed to use of a rapid-test-validation computing device to determine if a result of a rapid test device is valid and identify the result. The rapid-test-validation computing device captures images of the rapid test device and employs a first artificial intelligence mechanism to determine if the rapid test device is properly aligned in the images. The rapid-test-validation computing device then employs a second artificial intelligence mechanism to determine if a result of the rapid test device is valid or invalid. If the result is valid, the rapid-test-validation computing device employs a third artificial intelligence mechanism to determine and present an objective output of the rapid test device result to a user; otherwise, the rapid-test-validation computing device presents a notification to the user that the rapid test device result is invalid.

Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.

Abstract: Approaches are described for storing, managing, and dispensing products from automated multi-user kiosks. For example, a multi-user kiosk may include interface sides alternating with non-interface panels including at least one storage door for loading products. Products are stored in a shared storage within the kiosk. The shared storage may be a plurality of carousels stacked as a single column Each carousel can rotate independently of each other. Users are verified and authorized prior to purchasing products or accessing storage for loading products. A first carousel containing a first product may be rotated in a first direction to dispense the first product to a first user at a first side of the kiosk at substantially a same time as a second carousel containing a second product rotates in a second direction to dispense the second product to a second user at a second side of the kiosk.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: A receiver is formed as the physical inverse or relief of at least a portion of a machined part or casting. The receiver has accommodations for sensor systems that monitor the temperature of the part during a radiant heating process which is placed on top of the casting receiver to move through the radiant heating process.

Abstract: A manufacturing system is disclosed including a conveying apparatus with a plurality of rollers that form a travel path along which a ribbon is configured to be conveyed in a travel direction. The plurality of rollers including at least a tensioning roller having a shaft and a rotation wheel with a plurality of spokes that extend radially outward from the shaft, the plurality of spokes being configured to rotate about a longitudinal axis of the shaft to cause the ribbon to be conveyed in the travel direction. The manufacturing system further including a flow generator configured to direct a flow of fluid to the plurality of spokes to cause rotation of the plurality of spokes.

Abstract: In one aspect, the disclosure relates to topical formulations, methods of making same, and methods of treating hair loss using same. In an aspect, the present disclosure pertains to topical formulations for treatment of hair loss and/or to increase hair growth, the formulation comprising: a therapeutic composition comprising therapeutically effective amounts of azelaic acid, minoxidil, finasteride, and duasteride; and one or more compounding agents. In a further aspect, the present disclosure pertains to a method of treating hair loss by applying a disclosed topical formulation. In a further aspect, the present disclosure pertains to a method of enhancing hair grow by applying a disclosed topical formulation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Features for in-flight recovery of an unmanned aerial vehicle (UAV). A towline may be deployed by a host aircraft in-flight to recover an in-flight target UAV. The towline or portion thereof may be oriented nearly vertical. The towline may have a fitting thereon. A capture mechanism on the target UAV may have one or more deployable flaps that engage with the near vertical towline and fitting. The flaps may stow to secure the target aircraft to the towline and fitting. The host aircraft may then retract the towline to pull in the target UAV to the host aircraft using a hoist system having a winch. A latching system located in a pylon of the host aircraft, which may be under a wing, may have a towline connector that engages with and secures the target UAV. The host aircraft may have multiple hoist systems for deployment and/or recovery of multiple target UAV's.

Abstract: A process of forming a sintered article includes heating a green portion of a tape of polycrystalline ceramic and/or minerals in organic binder at a binder removal zone to a temperature sufficient to pyrolyze the binder; horizontally conveying the portion of tape with organic binder removed from the binder removal zone to a sintering zone; and sintering polycrystalline ceramic and/or minerals of the portion of tape at the sintering zone, wherein the tape simultaneously extends through the removal and sintering zones.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: A percussion massager feature describe herein provides for locking the control display through the touchscreen of the percussion massager to ensure accidental bumps to the display do not disrupt treatment.

Abstract: The disclosure provides modified pegRNAs comprising one or more appended nucleotide structural motifs which increase the editing efficiency during prime editing, increase half-life in vivo, and increase lifespan in a cell. Modifications include, but are not limited to, an aptamer (e.g., prequeosim-1 riboswitch aptamer or “evopreQi-1”) or a variant thereof, a pseudoknot (the MMLV viral genome pseudoknot or “Mpknot-1”) or a variant thereof, a tRNA (e.g., the modified tRNA used by MMLV as a primer for reverse transcription) or a variant thereof, or a G-quadruplex or a variant thereof. The disclosure further provides prime editor complexes comprising the modified pegRNAs and having improved characteristics and/or performance, including stability, improved cellular lifespan, and improved editing efficiency.

Abstract: This clamping tool uses optical distance verification with a laser. Clamping tools, like all tools, are known to be operated improperly. Many tools verify process completion by monitoring the pressure within the pneumatic tool. Previous qualifiers use pressure to determine many things. However, it often misses if a small object impedes a full stroke. With the addition of an optical laser sensor, we are able to determine if a clamping tool reaches full stroke.

Abstract: A system including a deep learning processor receives one or more control signals from one or more of a factory's process, equipment and control (P/E/C) systems during a manufacturing process. The processor generates expected response data and expected behavioral pattern data for the control signals. The processor receives production response data from the one or more of the factory's P/E/C systems and generates production behavioral pattern data for the production response data. The process compares at least one of: the production response data to the expected response data, and the production behavioral pattern data to the expected behavioral pattern data to detect anomalous activity. As a result of detecting anomalous activity, the processor performs one or more operations to provide notice or cause one or more of the factory's P/E/C systems to address the anomalous activity.

Abstract: According to at least one aspect of the present disclosure, an information-technology-design system is provided comprising at least one processor coupled to at least one memory, wherein the at least one processor is configured to receive information-technology-device information indicative of a plurality of information-technology devices in a space, the information-technology-device information including information-technology-device-location information, temperature information, and capture-index information, determine, based on the information-technology-device information, a containment type of the plurality of information-technology devices, select, based on the containment type, at least a portion of the capture-index information, determine, based on the information-technology-device-location information, the temperature information, and the at least the portion of the capture-index information, a respective cooling-performance assessment for each information-technology device of the plurality of informa

Abstract: Visual content to be displayed on a display of a user device is received. Obfuscation data for obscuring the visual content is generated and the obscured visual content is displayed on the display. A request to stop obscuring the visual content is transmitted from the user device to a remote device, in response to a drag gesture detected at the user device. As the drag gesture is performed, the obfuscation data is modified to reduce a level of obfuscation applied to the visual content before the request has been accepted, so that the visual content remains obscured but with a lower level of obfuscation. If the request is subsequently accepted at the remote device, the display is controlled to stop obscuring the visual content, thereby rendering the visual content fully visible on the display.

Abstract: There is provided a method of manufacturing a sealing member (42). The method comprises the steps of: (a) providing a mould having a cavity, a polymer injection port and a gas inlet port (38); (b) injecting a polymer and a blowing agent through the polymer injection port (28) into the cavity of the mould; and (c) introducing gas through the gas inlet port (38) into the cavity of the mould, to form a sealing member (42). The sealing member (42) comprises an internal chamber (44) at least partially bounded by a resiliently deformable enclosing wall formed of the polymer, the enclosing wall including an external surface, the external surface having a form that is determined by the cavity of the mould.