Patents by Inventor James Winkelman

James Winkelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10764538
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: September 1, 2020
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Patent number: 10094764
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 9, 2018
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Patent number: 10010274
    Abstract: The systems, methods, and devices described herein generally involve monitoring and/or quantification of various analyte levels in a biological fluid using one or more implantable sensors. In various aspects, systems, methods, and devices described herein can provide for the in situ calibration and/or cleaning of such sensors when implanted in the patient. The systems and devices disclosed herein can, for example, continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and periodically calibrate and/or clean the sensor without using finger sticks or additional, invasive calibration techniques. By way of non-limiting example, systems and devices disclosed herein can enable continuous monitoring of analyte concentrations (e.g., glucose) in subcutaneous interstitial fluid for several hours to a few days.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: July 3, 2018
    Inventor: James Winkelman
  • Publication number: 20180007319
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: March 20, 2017
    Publication date: January 4, 2018
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Patent number: 9602777
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: March 21, 2017
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Publication number: 20160209320
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: December 18, 2015
    Publication date: July 21, 2016
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20160073940
    Abstract: Systems, methods, and devices are disclosed for monitoring or quantifying of various analyte levels in a biological fluid using one or more implantable sensors by providing in situ calibration and/or cleaning of such sensors when implanted in a patient. The systems and devices can continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and can be periodically calibrated and/or cleaned without using finger sticks or other calibration techniques. For example, the invention can facilitate continuous monitoring of glucose concentrations in subcutaneous interstitial fluid for several hours to a few days. In certain embodiments, the invention can employ two reservoirs, one containing and a known concentration of an analyte and the other containing a diluent, and a mixer for mixing analyte from the first reservoir diluent from the second reservoir to obtain a calibration fluid of a desired concentration.
    Type: Application
    Filed: August 21, 2015
    Publication date: March 17, 2016
    Inventor: James Winkelman
  • Patent number: 9217695
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: December 22, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20150355078
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: April 27, 2015
    Publication date: December 10, 2015
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Patent number: 9083857
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 14, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Patent number: 9017610
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: April 28, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20140371553
    Abstract: The systems, methods, and devices described herein generally involve monitoring and/or quantification of various analyte levels in a biological fluid using one or more implantable sensors. In various aspects, systems, methods, and devices described herein can provide for the in situ calibration and/or cleaning of such sensors when implanted in the patient. The systems and devices disclosed herein can, for example, continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and periodically calibrate and/or clean the sensor without using finger sticks or additional, invasive calibration techniques. By way of non-limiting example, systems and devices disclosed herein can enable continuous monitoring of analyte concentrations (e.g., glucose) in subcutaneous interstitial fluid for several hours to a few days.
    Type: Application
    Filed: December 17, 2012
    Publication date: December 18, 2014
    Inventor: James WINKELMAN
  • Patent number: 8815537
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: August 26, 2014
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20130070077
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: CONSTITUTION MEDICAL, INC.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Publication number: 20110070606
    Abstract: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: April 27, 2010
    Publication date: March 24, 2011
    Applicant: Constitution Medical, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser, James Linder
  • Publication number: 20110014645
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: May 21, 2010
    Publication date: January 20, 2011
    Applicant: Constitution Medical Investors, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20100285379
    Abstract: A technique includes operating an electrochemical cell stack in a power producing mode, including communicating a fuel flow in an anode chamber of the stack and communicating an oxidant flow in a cathode chamber of the stack. The technique includes halting the oxidant flow and monitoring a voltage of the stack while the oxidant flow is halted, and in response to the voltage decreasing below a predefined threshold, transitioning the stack into an electrochemical cell pumping mode.
    Type: Application
    Filed: November 13, 2007
    Publication date: November 11, 2010
    Inventors: Jeffrey W. Schrieber, Richard Maddaloni, Zhigang Qi, Chris Brown, Christopher J. Chuah, P.E., Glen Benson, James Winkelman
  • Publication number: 20100284602
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: May 21, 2010
    Publication date: November 11, 2010
    Applicant: Constitution Medical Investors, Inc.
    Inventors: James WINKELMAN, Milenko TANASIJEVIC, David ZAHNISER
  • Publication number: 20090269799
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Application
    Filed: April 27, 2009
    Publication date: October 29, 2009
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20060162689
    Abstract: A system for controlling fuel injection parameters of a diesel engine is provided. The system includes an engine cylinder, a fuel injector, a glow plug, an ionization sensor and a controller. The fuel injector provides fuel to the engine cylinder and initiates the combustion process within the engine cylinder. The ionization sensor senses ionization during the combustion process and generates an ionization signal provided to the controller. Based on the ionization signal the controller is configured to control the fuel injection parameters, such as the number of injections, quantity and timing of each fuel injection events and the maximum rate of engine exhaust gas recirculation.
    Type: Application
    Filed: January 25, 2005
    Publication date: July 27, 2006
    Inventors: James Winkelman, Guoming Zhu, Shankar Raman