Patents by Inventor James Z. HUI

James Z. HUI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibodies, methods for production thereof and methods of treatment
    Patent number: 11913026
    Abstract: A bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for producing bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for treating a subject in need thereof comprising administering to the subject an isolated bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: February 27, 2024
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, James Z. Hui, Burcin Altun, Fabiana Zappala
  • COMPOSITIONS AND METHODS FOR MAKING ANTIBODY CONJUGATES
    Publication number: 20230046047
    Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
    Type: Application
    Filed: August 25, 2021
    Publication date: February 16, 2023
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, James Z. Hui
  • METHOD FOR THE SITE-SPECIFIC COVALENT CROSS-LINKING OF ANTIBODIES TO SURFACES
    Publication number: 20220214337
    Abstract: This invention relates to to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
    Type: Application
    Filed: October 22, 2021
    Publication date: July 7, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew TSOURKAS, James Z. HUI
  • Method for the site-specific covalent cross-linking of antibodies to surfaces
    Patent number: 11156608
    Abstract: This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 26, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, James Z. Hui
  • Compositions and methods for making antibody conjugates
    Patent number: 11123440
    Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: September 21, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, James Z. Hui
  • BISPECIFIC CYTOTOXIC LYMPHOCYTE OR MACROPHAGE-REDIRECTING AUTOANTIBODIES, METHODS FOR PRODUCTION THEREOF AND METHODS OF TREATMENT
    Publication number: 20200299646
    Abstract: A bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for producing bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody comprising a cytotoxic lymphocyte or macrophage targeting domain and an autoantibody. Methods for treating a subject in need thereof comprising administering to the subject an isolated bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody.
    Type: Application
    Filed: March 17, 2020
    Publication date: September 24, 2020
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew TSOURKAS, James Z. HUI, Burcin ALTUN, Fabiana ZAPPALA
  • COMPOSITIONS AND METHODS FOR MAKING ANTIBODY CONJUGATES
    Publication number: 20180344871
    Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
    Type: Application
    Filed: May 12, 2016
    Publication date: December 6, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew TSOURKAS, James z. Hui
  • Method for the site-specific covalent cross-linking of antibodies to surfaces
    Publication number: 20160041157
    Abstract: This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 11, 2016
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew TSOURKAS, James Z. HUI