Patents by Inventor James Zhu
James Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240092773Abstract: The present invention relates to dihydro-cyclopenta-isoquinoline derivatives of formula (I): processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular, disorders caused by the interaction of IgE with the Fc?RI receptor.Type: ApplicationFiled: December 22, 2020Publication date: March 21, 2024Inventors: Timothy John NORMAN, Zhaoning ZHU, Selvaratnam SUGANTHAN, Konstantinos RAMPALAKO, James MADDEN, Jag Paul HEER, Richard Jeremy FRANKLIN, Rickki Lee CONNELLY, Thierry DEMAUDE, Gregory William HASLETT, Benedicte LALLEMAND, Nathaniel Julius Thomas MONCK, Julian Hugh ROWLEY, Giancarlo TRANI
-
Publication number: 20240095005Abstract: The present disclosure relates generally to systems and methods for providing sets of compatible firmware versions (e.g., cross-compatibility solution) for flashing (e.g., programming or re-programming) different devices of a network of devices (e.g., an industrial automation system) when using a flashing application. Providing the compatible firmware versions of such network of devices may facilitate flashing the devices with compatible firmware, based on a topology of the network of devices, to prevent functional errors in the network of devices. The present systems and methods may also be applicable to determining and providing cross-compatibility solution between different firmware, as well as software, used by different devices of a network of devices.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Inventors: Fabio Malaspina, James A. Bizily, Chunhui Zhu, Yuan Wei, Jingfeng Chen, Emily J. Smith
-
Publication number: 20240093407Abstract: Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice.Type: ApplicationFiled: November 29, 2023Publication date: March 21, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Fang Liu, Xiaoyang Zhu, James Hone, Sang Hoon Chae
-
Patent number: 11936028Abstract: An electrochemical system includes: an anode; a cathode; an electrolyte; and at least one dielectrically heatable material.Type: GrantFiled: July 13, 2021Date of Patent: March 19, 2024Assignee: Ampcera Inc.Inventors: James Emery Brown, Hui Du, Chen Chen, Sumin Zhu
-
Publication number: 20240087592Abstract: Various embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for pre-processing dual-channel voice data for an automatic speech recognition mode. The method comprises creating one or more spectrograms for each channel of the dual-channel voice data by applying fast Fourier transform and generating power spectral density. The one or more balanced power spectrograms are created by merging the spectrograms of the channels, and are provided as input for acoustic and language processing by an automatic speech recognition machine learning model.Type: ApplicationFiled: September 8, 2022Publication date: March 14, 2024Inventors: James J. Mou, Jun Li, Julie Zhu
-
Patent number: 11926619Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.Type: GrantFiled: April 8, 2019Date of Patent: March 12, 2024Assignee: Eisai R & D Management Co., Ltd.Inventors: Gregg F. Keaney, John Wang, Baudouin Gerard, Kenzo Arai, Xiang Liu, Guo Zhu Zheng, Kazunobu Kira, Lisa A. Marcaurelle, Marta Nevalainen, Ming-Hong Hao, Morgan Welzel O'Shea, Parcharee Tivitmahaisoon, Sudeep Prajapati, Tuoping Luo, Nicholas C. Gearhart, Jason T. Lowe, Yoshihiko Kotake, Satoshi Nagao, Regina Mikie Kanada Sonobe, Masayuki Miyano, Norio Murai, Andrew Cook, Shelby Ellery, Atsushi Endo, James Palacino, Dominic Reynolds
-
Patent number: 11912721Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.Type: GrantFiled: November 24, 2020Date of Patent: February 27, 2024Assignees: UCB Biopharma SRL, SanofiInventors: Teresa De Haro Garcia, Michael Deligny, Jag Paul Heer, Joanna Rachel Quincey, Mengyang Xuan, Zhaoning Zhu, Daniel Christopher Brookings, Mark Daniel Calmiano, Yves Evrard, Martin Clive Hutchings, James Andrew Johnson, Sophie Jadot, Jean Keyaerts, Malcolm MacCoss, Matthew Duncan Selby, Michael Alan Shaw, Dominique Louis Leon Swinnen, Laurent Schio, Yann Foricher, Bruno Filoche-Romme
-
Publication number: 20240053677Abstract: Methods of forming an array of patterns on a substrate are provided. A replication medium is coated onto a relief structure of a patterned template and solidified. Patterned templates with the replication medium are transferred to an array of sub-regions of a tiling region of a substrate, where heat and/or radiation can be applied to the replication medium. The patterned templates are then removed from the substrate to form a patterned surface structure on the substrate.Type: ApplicationFiled: December 28, 2021Publication date: February 15, 2024Inventors: Ashley R. Sonnier, James Zhu, Lucas J. Hunt, Edwin L. Kusilek, Paul B. Armstrong
-
Publication number: 20240045324Abstract: Methods of forming an array of patterns on a substrate are provided. An array of protective tiles formed from a protectant resin is provided to cover an array of sub-regions on the substrate. An array of patterns is formed on the substrate by sequentially repeating steps (i) and (ii) for each sub-region: (i) removing the protective tile from one of the sub-regions to expose the first major surface underneath; and (ii) forming a pattern on the exposed first major surface within the one of the sub-regions.Type: ApplicationFiled: December 8, 2021Publication date: February 8, 2024Inventors: Lucas J. Hunt, Ashley R. Sonnier, James Zhu, Edwin L. Kusilek, Paul B. Armstrong, William B. Kolb, Caleb T. Nelson, Jeffrey L. Solomon, James M. Nelson, Samuel R. Hei, David J. Tarnowski, Henrik B. van Lengerich
-
Patent number: 11894164Abstract: A stretchable conductor includes a substrate with a first major surface, wherein the substrate is an elastomeric material. An elongate wire is on the first major surface of the substrate; the wire includes a first end and a second end, and further includes at least one arcuate region between the first end and the second end. At least one portion of the arcuate region of the wire in the region has a first surface area portion embedded in the surface of the substrate and a second surface area portion unembedded on the substrate and exposed in an amount sufficient to render at least an area of the substrate in the region electrically conductive. The unembedded second surface portion of the arcuate region may lie above or below a plane of the substrate. Composite articles including a stretchable conductor in durable electrical contact with a conductive fabric are also disclosed.Type: GrantFiled: September 23, 2020Date of Patent: February 6, 2024Assignee: 3M INNOVATIVE PROPERTIES COMPNAYInventors: Ankit Mahajan, James Zhu, Saagar A. Shah, Mikhail L. Pekurovsky, Vivek Krishnan, Kevin T. Reddy, Christopher B. Walker, Jr., Michael A. Kropp, Kara A. Meyers, Teresa M. Goeddel, Thomas J. Metzler, Jonathan W. Kemling, Roger W. Barton
-
Publication number: 20230026261Abstract: A sensor element and sensor comprising the sensing element. The sensor includes, in order, an absorptive layer, a metallic layer and an optically transparent, dielectric substrate. The absorptive layer has a polymer of intrinsic microporosity having an average pore volume of at least 0.1 nm3. The metallic layer has a plurality of openings each extending from the first to the second major surface of the metallic layer, the openings having a pitch in a range from 50 nm to 5000 nm, wherein the openings have an opening size in a range from 5% to 95% percent of the pitch.Type: ApplicationFiled: December 11, 2020Publication date: January 26, 2023Inventors: Myungchan Kang, Daniel M. Lentz, Masayuki Nakamura, Karl K. Stensvad, James Zhu
-
Patent number: 11446918Abstract: A method of applying a pattern to a nonplanar surface. A stamp has a major surface with pattern elements having a lateral dimension of greater than 0 and less than about 5 microns. The major surface of the stamp has a functionalizing molecule with a functional group selected to chemically bind to the nonplanar surface. The stamp is positioned to initiate rolling contact with the nonplanar surface, and contacts the nonplanar surface to form a self-assembled monolayer (SAM) of the functionalizing material thereon and impart the arrangement of pattern elements thereto. The major surface of the stamp is translated with respect to the nonplanar surface such that: a contact pressure is controlled at an interface between the stamping surfaces and the nonplanar surface, and a contact force at the interface is allowed to vary while the stamping surfaces and the nonplanar surface are in contact with each other.Type: GrantFiled: December 26, 2018Date of Patent: September 20, 2022Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: James Zhu, Karl K. Stensvad, Daniel M. Lentz, Thomas J. Metzler, Moses M. David
-
Publication number: 20210347135Abstract: Materials and methods useful in forming nano-scale features on substrates, and articles such as optical films incorporating such nano-scale patterned substrates.Type: ApplicationFiled: November 8, 2019Publication date: November 11, 2021Inventors: Henrik B. van Lengerich, Karl K. Stensvad, Edwin L. Kusilek, Mathew S. Stay, Caleb T. Nelson, Christopher S. Lyons, Moses M. David, Jeffrey L. Solomon, Martin B. Wolk, Nicholas C. Erickson, James Zhu, James M. Nelson
-
Publication number: 20210280337Abstract: A stretchable conductor includes a substrate with a first major surface, wherein the substrate is an elastomeric material. An elongate wire is on the first major surface of the substrate; the wire includes a first end and a second end, and further includes at least one arcuate region between the first end and the second end. At least one portion of the arcuate region of the wire in the region has a first surface area portion embedded in the surface of the substrate and a second surface area portion unembedded on the substrate and exposed in an amount sufficient to render at least an area of the substrate in the region electrically conductive. The unembedded second surface portion of the arcuate region may lie above or below a plane of the substrate. Composite articles including a stretchable conductor in durable electrical contact with a conductive fabric are also disclosed.Type: ApplicationFiled: September 23, 2020Publication date: September 9, 2021Inventors: Ankit Mahajan, James Zhu, Saagar A. Shah, Mikhail L. Pekurovsky, Vivek Krishnan, Kevin T. Reddy, Christopher B. Walker, JR., Michael A. Kropp, Kara A. Meyers, Teresa M. Goeddel, Thomas J. Metzler, Jonathan W. Kemling, Roger W. Barton
-
Publication number: 20210260901Abstract: A method of applying a pattern to a nonplanar surface with a radius of curvature. A stamp with a major surface has a relief pattern of pattern elements extending away from a base surface. Each pattern element has a stamping surface with a lateral dimension 0 to 5 microns. An ink applied on the stamping surface includes a functionalizing molecule with a functional group that chemically binds to the nonplanar surface. The stamp is positioned to initiate rolling contact between the nonplanar surface and the major surface of the stamp. The stamping surface of the pattern elements contacts the nonplanar surface to form a self-assembled monolayer of the functionalizing material on the nonplanar surface and impart the arrangement of pattern elements. A relative position of the stamping surface is controlled with respect to the nonplanar surface while the major surface of the stamp contacts the nonplanar surface.Type: ApplicationFiled: June 21, 2019Publication date: August 26, 2021Inventors: James Zhu, Karl K. Stensvad, Daniel M. Lentz, Thomas J. Metzler, Moses M. David, Jennifer A. Timm, Terrance A. Pechacek
-
Publication number: 20210178622Abstract: Methods and apparatuses for generating fiducials via die cutting are provided. Laterally arranged die cutting members and fiducial-making members are provided onto a roller to respectively cut a first pattern and a fiducial mark on the same side of a web in a rotatory die cutting process. The fiducial mark is used to register a second pattern provided by a downstream station to the first pattern.Type: ApplicationFiled: October 18, 2018Publication date: June 17, 2021Inventors: Thomas J. Metzler, James Zhu, Daniel J. Theis, David D. Miller, Donald G. Peterson, Mikhail L. Pekurovsky
-
Patent number: 10971468Abstract: Processes for automatic registration between a solid circuit die and electrically conductive interconnects, and articles or devices made by the same are provided. The solid circuit die is disposed on a substrate with contact pads aligned with channels on the substrate. Electrically conductive traces are formed by flowing a conductive liquid in the channels toward the contact pads to obtain the automatic registration.Type: GrantFiled: November 16, 2017Date of Patent: April 6, 2021Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Ankit Mahajan, Mikhail L. Pekurovsky, Matthew S. Stay, Daniel J. Theis, Ann M. Gilman, Shawn C. Dodds, Thomas J. Metzler, Matthew R. D. Smith, Roger W. Barton, Joseph E. Hernandez, Saagar A. Shah, Kara A. Meyers, James Zhu, Teresa M. Goeddel, Lyudmila A. Pekurovsky, Jonathan W. Kemling, Jeremy K. Larsen, Jessica Chiu, Kayla C. Niccum
-
Publication number: 20210094272Abstract: A method of applying a pattern to a nonplanar surface. A stamp has a major surface with pattern elements having a lateral dimension of greater than 0 and less than about 5 microns. The major surface of the stamp has a functionalizing molecule with a functional group selected to chemically bind to the nonplanar surface. The stamp is positioned to initiate rolling contact with the nonplanar surface, and contacts the nonplanar surface to form a self-assembled monolayer (SAM) of the functionalizing material thereon and impart the arrangement of pattern elements thereto. The major surface of the stamp is translated with respect to the nonplanar surface such that: a contact pressure is controlled at an interface between the stamping surfaces and the nonplanar surface, and a contact force at the interface is allowed to vary while the stamping surfaces and the nonplanar surface are in contact with each other.Type: ApplicationFiled: December 26, 2018Publication date: April 1, 2021Inventors: James Zhu, Karl K. Stensvad, Daniel M. Lentz, Thomas J. Metzler, Moses M. David
-
Publication number: 20210031740Abstract: System (195) and method (300) for providing an extra torque from a motor (110) to a brake pedal (115). The system comprises a brake pedal (115) having an input rod; a motor (110); a sensor (125); and an electronic controller (130) configured to receive a velocity of the input rod of the brake pedal (115) from the sensor (125), determine a torque ratio based on the velocity, determine a differential stroke of the brake pedal (115), determine a torque offset based on the differential stroke, determine an extra torque based on the torque ratio and the torque offset, and control the motor (110) to apply the extra torque to the brake pedal (115).Type: ApplicationFiled: January 22, 2019Publication date: February 4, 2021Inventors: Patrick Christian Schaefer, James Zhu, Hind Harkati, Benoit Herve, Karsten Bieltz
-
Publication number: 20210035875Abstract: Processes for automatic registration between a solid circuit die and electrically conductive interconnects, and articles or devices made by the same are provided. The solid circuit die is disposed at a registration area of a substrate. Fluid channels extend into the registration area and have a portion underneath the bottom surface of the solid circuit die. Electrically conductive traces are formed by flowing a conductive liquid in the channels toward contact pads on the bottom surface of the circuit die to obtain the automatic registration.Type: ApplicationFiled: February 27, 2019Publication date: February 4, 2021Inventors: Ankit Mahajan, Mikhail L. Pekurovsky, Saagar A. Shah, Thomas J. Metzler, Kara A. Meyers, James Zhu, Teresa M. Goeddel, Lyudmila A. Pekurovsky, Jonathan W. Kemling, Jeremy K. Larsen