Patents by Inventor James Zhu

James Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220380352
    Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 1, 2022
    Inventors: Ermira PAZOLLI, Silvia BUONAMICI, Thiwanka SAMARAKOON, Sudeep PRAJAPATI, Nathan FISHKIN, James PALACINO, Michael SEILER, Ping ZHU, Andrew COOK, Peter SMITH, Xiang LIU, Shelby ELLERY, Dominic REYNOLDS, Lihua YU, Zhenhua WU, Shouyong PENG, Nicholas CALANDRA, Megan SHEEHAN, Yonghong XIAO
  • Patent number: 11513556
    Abstract: An accessory device for a portable electronic device is described. The accessory device includes a front cover connected to a back cover. The front cover includes multiple segments rotatable with respect to each other. The segments include magnets that allow the segments, through magnetic coupling, to couple with another segment or with the portable electronic device. When the front cover engages the back cover, a user may remove, or pull away, a segment from the back cover, causing the remaining segments to sequentially fall away from the back cover. In some instances, when the front cover at least partially engages the back cover, one of the segments includes magnets designed to couple with magnets in the back cover, but not with magnets in another segment. The accessory device may further include an opening that receives a camera assembly of the portable electronic device and forms a mechanical interlock.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: November 29, 2022
    Assignee: Apple Inc.
    Inventors: James A. Stryker, Caitlin M. Mclain, Travis C. Pedley, Nicholas A. Treadwell, Hao Zhu, Yang Zhou
  • Publication number: 20220374066
    Abstract: In one embodiment, a processor includes: at least one core; and a power controller coupled to the at least one core. The power controller may include: a workload monitor circuit to calculate a background task ratio based on a first amount of time that the at least one core executed background tasks during an active duration; and a control circuit to dynamically apply a power management policy for a background mode when the background task ratio exceeds a background mode threshold, the power management policy for the background mode to reduce power consumption of the processor. Other embodiments are described and claimed.
    Type: Application
    Filed: August 2, 2022
    Publication date: November 24, 2022
    Inventors: JIANFANG ZHU, Deepak Samuel Kirubakaran, Raoul Rivas Toledano, Chee Lim Nge, Rajshree Chabukswar, James Hermerding, II, Sudheer Nair, William Braun, Zhongsheng Wang, Russell Fenger, Udayan Kapaley
  • Publication number: 20220340620
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: April 6, 2022
    Publication date: October 27, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: SCOTT DIEHN, JAMES J. ENGLISH, LU LIU, AZALEA S. ONG, JARRED KENNETH ORAL, BARBARA ROSEN, UTE SCHELLENBERGER, INGRID UDRANSZKY, JUN-ZHI WEI, WEIPING XIE, GENHAI ZHU
  • Patent number: 11478665
    Abstract: Techniques for particle beam therapy include receiving a target region inside a subject for particle therapy, a minimum dose inside the target region, and a maximum dose inside the subject but outside target region. Multiple beam axis angles are determined, each involving a gantry angle and a couch position. Multiple spots within the target region are determined. For each beam axis angle a pristine particle scan beam (not coaxial with any other particle scan beam) is determined such that a Bragg Peak is directed to a spot, and repeated until every spot is subjected to a Bragg Peak or an intersection of two or more such pristine scan beams. Output data indicating the pristine beamlets is stored for operation of a particle beam therapy apparatus.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: October 25, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: James William Snider, III, William F. Regine, Mingyao Zhu, Katja Langen
  • Publication number: 20220337070
    Abstract: A method includes interpreting a contactor open event and a contactor load value for a contactor positioned on a motive power circuit for a mobile application, determining that a contactor opening event under load has occurred in response to the contactor open event and the contactor load value, and updating a contactor wear condition in response to the contactor opening event under load, wherein updating the contactor wear condition comprises accumulating a number of the contactor opening events under load.
    Type: Application
    Filed: May 5, 2022
    Publication date: October 20, 2022
    Inventors: Justin Keith Griffiths, Nilesh Surase, Ritika Shetty, Shalini Tripathy, Somdut Dey, Madhavi Gupta, Mayura Madane, Sadiya Qureshi, Toseed Khan, Amit Chavan, Kumar Prasad Telikepalli, Atul Solvande, Hao Wang, Jiong Chen, Yueyue Deng, Jason Carroll, Srinivasan Arjun Tekalur, Jacob William Green, Ashok Chakravarthi Kandru, Cheng Luo, Tianyang Jiang, Cheng Wan, Ye Zhu, John Trublowski, Robert Stephen Douglass, Rajen Modi, Nilay Mehta, Laura Natali Valencia Fritsch, Han Li, Dongxin JIn, Lewei Qian, Jun Li, Hongrae Kim, Daniel R. Ouwenga, Patrick Herranz, Miroslav Horejs, Rohit Baranwal, Zhe Zhang, Martin Wayne Mensch, Brandon William Fisher, Austin Robert Zurface, Jeff Howard Urian, James David, Bharath Kumar Suda, Asheesh Kumar Soni, Rene Guy Gallet, Michael Scott Sullivan, Karsten Gerving, Guido Völlmar, Gerd Schmitz, Christoph Bausch, Ute Molitor, Lutz Friedrichsen, Kai Schroeder, Julia Otte, Madeline Philipsohn, Norbert Roesner, Volker Lang, Johannes Meissner, Paolo D'Amico, Jalpa Shah, Meng Wang, Damrongrit Piyabongkarn, Niles Stephen Ramseyer, Dennis Dukaric, Matt Haylock, Anvaya R. Hingangave, Devendra Patil
  • Publication number: 20220336813
    Abstract: Polyimide binders and their polyamic precursors to be used for forming electrode structures are provided. The designed polyamic binder precursors are water-soluble, and the resulting polyimide binders are mechanically strong, electrochemically and thermally stable. The properties of polyimide binders have led to significant improvement in electrode compatibility towards new manufactural processes.
    Type: Application
    Filed: April 14, 2022
    Publication date: October 20, 2022
    Inventors: SUBRAMANYA P. HERLE, Gao LIU, Jie GUAN, James CUSHING, Ajey M. JOSHI, Tianyu ZHU, Chen FANG, Thanh-Nhan TRAN
  • Publication number: 20220334816
    Abstract: The present disclosure relates generally to systems and methods for providing sets of compatible firmware versions (e.g., cross-compatibility solution) for flashing (e.g., programming or re-programming) different devices of a network of devices (e.g., an industrial automation system) when using a flashing application. Providing the compatible firmware versions of such network of devices may facilitate flashing the devices with compatible firmware, based on a topology of the network of devices, to prevent functional errors in the network of devices. The present systems and methods may also be applicable to determining and providing cross-compatibility solution between different firmware, as well as software, used by different devices of a network of devices.
    Type: Application
    Filed: July 1, 2022
    Publication date: October 20, 2022
    Inventors: Fabio Malaspina, James A. Bizily, Chunhui Zhu, Yuan Wei, Jingfeng Chen, Emily J. Smith
  • Patent number: 11472794
    Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: October 18, 2022
    Assignee: UCB Biopharma SRL
    Inventors: Gareth Neil Brace, Rose Elizabeth Bardell-Cox, Gregory Foulkes, James Richard Frost, Helen Tracey Horsley, Elizabeth Pearl Jones, Fabien Claude Lecomte, James Thomas Reuberson, Monika-Sarah Elizabeth Dorothea Schulze, Richard David Taylor, Wei Tsung Yau, Zhaoning Zhu
  • Patent number: 11473545
    Abstract: Devices and systems for determining an alternator condition in a motor vehicle are provided. The method includes performing a plurality of micro wakeups to capture voltage values during a cranking event, determining the maximum cranking voltage and its timestamp, detecting an ignition signal, determining the maximum device voltage and its timestamp, and determining a potential alternator undercharging condition if a duration between the maximum cranking voltage timestamp and the maximum device voltage timestamp is greater than an undercharging indicator duration threshold. Advantageously, an alternator may be repaired or replaced before it fails thus averting having the motor vehicles inoperable.
    Type: Grant
    Filed: May 30, 2022
    Date of Patent: October 18, 2022
    Assignee: Geotab Inc.
    Inventors: Meghan Frances Fotak, Jailin Zhu, James David Johnston, Weinan Sun, Matthew Konski, Michael Angelo David Santorelli, Daniel Alec Sheen, Robert Spencer Hockin, Xiaohui Yu
  • Patent number: 11466075
    Abstract: Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: October 11, 2022
    Assignee: University of Maryland, Baltimore
    Inventors: Hanping Feng, James Eugene Galen, Kevin Chen, Yixuan Zhu
  • Publication number: 20220305046
    Abstract: Described are methods for treating alpha-1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 29, 2022
    Applicant: Arrowhead Pharmaceuticals, Inc.
    Inventors: Bruce Given, Dawn Christianson, James C. Hamilton, Zhen Li, Rui Zhu, Christine Wooddell, Tao Pei
  • Patent number: 11452340
    Abstract: In one embodiment, an article of footwear including an upper is described. The upper includes a braid body and at least one component. The braid body includes at least one braided layer. A reinforcement element is attached to the braid body along a connection area using a connecting stitch. The component is attached to the braid body at the connection area using a zigzag stitch including a thread that passes through the component at a first location and passes through the reinforcement element and the braid body at a second location. The second location extends beyond the connecting stitch attaching the reinforcement element to the braid body.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 27, 2022
    Assignee: Under Armour, Inc.
    Inventors: Craig Santos, Carman Zhu, James Huang
  • Patent number: 11455842
    Abstract: Methods and systems for determining an alternator condition in a motor vehicle are provided. The method includes performing a plurality of micro wakeups to capture voltage values during a cranking event, determining the maximum cranking voltage and its timestamp, detecting an ignition signal, determining the maximum device voltage and its timestamp, and determining a potential alternator undercharging condition if a duration between the maximum cranking voltage timestamp and the maximum device voltage timestamp is greater than an undercharging indicator duration threshold. Advantageously, an alternator may be repaired or replaced before it fails thus averting having the motor vehicle inoperable.
    Type: Grant
    Filed: May 30, 2022
    Date of Patent: September 27, 2022
    Assignee: Geotab Inc.
    Inventors: Meghan Frances Fotak, Jialin Zhu, James David Johnston, Weinan Sun, Matthew Konski, Michael Angelo David Santorelli, Daniel Alec Sheen, Robert Spencer Hockin, Xiaohui Yu
  • Patent number: 11446918
    Abstract: A method of applying a pattern to a nonplanar surface. A stamp has a major surface with pattern elements having a lateral dimension of greater than 0 and less than about 5 microns. The major surface of the stamp has a functionalizing molecule with a functional group selected to chemically bind to the nonplanar surface. The stamp is positioned to initiate rolling contact with the nonplanar surface, and contacts the nonplanar surface to form a self-assembled monolayer (SAM) of the functionalizing material thereon and impart the arrangement of pattern elements thereto. The major surface of the stamp is translated with respect to the nonplanar surface such that: a contact pressure is controlled at an interface between the stamping surfaces and the nonplanar surface, and a contact force at the interface is allowed to vary while the stamping surfaces and the nonplanar surface are in contact with each other.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: September 20, 2022
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: James Zhu, Karl K. Stensvad, Daniel M. Lentz, Thomas J. Metzler, Moses M. David
  • Patent number: 11445737
    Abstract: A plant protein snack with meat-like texture food product generally includes a plant based structured product having layered fibers that are cross-linked yet generally aligned along a longitudinal axis and that mimics the look and organoleptic properties of meat jerky products. Methods of making the food product are described.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: September 20, 2022
    Assignee: Frito-Lay North America, Inc.
    Inventors: Yi Zhu, James Coomes, Thomas Trezza, Charlene Gladden
  • Publication number: 20220280918
    Abstract: Sorbent polymer composites and a solution-casting method of making hydrophobic sorbent polymer composites for CO2 adsorption applications are described. The sorbent polymer composites are comprised of a polymer matrix, a dispersed CO2 sorbent, and an optional filler particle for hydrophobicity modification.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 8, 2022
    Inventors: David P. Hopkinson, Lingxiang Zhu, James S. Baker, Patrick F. Muldoon
  • Patent number: 11422616
    Abstract: In one embodiment, a processor includes: at least one core; and a power controller coupled to the at least one core. The power controller may include: a workload monitor circuit to calculate a background task ratio based on a first amount of time that the at least one core executed background tasks during an active duration; and a control circuit to dynamically apply a power management policy for a background mode when the background task ratio exceeds a background mode threshold, the power management policy for the background mode to reduce power consumption of the processor. Other embodiments are described and claimed.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 23, 2022
    Assignee: Intel Corporation
    Inventors: Jianfang Zhu, Deepak Samuel Kirubakaran, Raoul Rivas Toledano, Chee Lim Nge, Rajshree Chabukswar, James Hermerding, II, Sudheer Nair, William Braun, Zhongsheng Wang, Russell Fenger, Udayan Kapaley
  • Patent number: 11416231
    Abstract: The present disclosure relates generally to systems and methods for providing sets of compatible firmware versions (e.g., cross-compatibility solution) for flashing (e.g., programming or re-programming) different devices of a network of devices (e.g., an industrial automation system) when using a flashing application. Providing the compatible firmware versions of such network of devices may facilitate flashing the devices with compatible firmware, based on a topology of the network of devices, to prevent functional errors in the network of devices. The present systems and methods may also be applicable to determining and providing cross-compatibility solution between different firmware, as well as software, used by different devices of a network of devices.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: August 16, 2022
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Fabio Malaspina, James A. Bizily, Chunhui Zhu, Yuan Wei, Jingfeng Chen, Emily J. Smith
  • Publication number: 20220242899
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 4, 2022
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG