Patents by Inventor James Zhu

James Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10854355
    Abstract: A stretchable conductor includes a substrate with a first major surface and an elongate wire, wherein the substrate is an elastomeric material, the elongate wire is on the first major surface of the substrate, the wire includes a first end and a second end, and further includes at least one arcuate region between the first end and the second end. At least one portion of the arcuate region of the wire in the region has a first surface area portion embedded in the surface of the substrate and a second surface area portion unembedded on the substrate and exposed in an amount sufficient to render at least an area of the substrate in the region electrically conductive. The unembedded second surface portion of the arcuate region may lie above or below a plane of the substrate. Additionally, different methods of preparing said stretchable conductor are disclosed. Composite articles including said stretchable conductor in durable electrical contact with a conductive fabric are also disclosed.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: December 1, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Ankit Mahajan, Jr., James Zhu, Saagar A. Shah, Mikhail L. Pekurovsky, Vivek Krishnan, Kevin T. Reddy, Christopher B. Walker, Jr., Michael A. Kropp, Kara A. Meyers, Teresa M. Goeddel, Thomas J. Metzler, Jonathan W. Kemling, Roger W. Barton
  • Publication number: 20200359610
    Abstract: This present invention relates to transgenic animals useful to study human diseases. Specifically, the invention relates to transgenic animals expressing at least two human proteins (optionally in replacement of the counterpart proteins in the animal) whereas a first human protein interacts with a second human protein. The transgenic animals can then be used for evaluating drugs or building disease models that are related to the expressed human proteins in the animals. The animals and methods disclosed herein reduce the possibility identifying a false-positive compound—the compound that show an effect in a naturally-occurring, non-transgenic animal but may not necessarily work or be therapeutic in human, since the compound may only interrupt the interaction between two animal proteins not necessarily two related human proteins.
    Type: Application
    Filed: July 31, 2020
    Publication date: November 19, 2020
    Inventor: James ZHU
  • Patent number: 10838297
    Abstract: A method of patterning a cylindrical tool, including providing a stamp including a base and a layer of solid state ionic conductor thereon, applying a negative of a predetermined pattern of features on a major surface of the solid state ionic conductor, providing a cylindrical tool having a metallic surface positioned proximate the stamp, and applying an electric field between the metallic surface and a cathode while moving the stamp against the metallic surface in rolling line contact so as to impart the predetermined pattern of features onto the metallic surface, wherein the cathode is either the base or a conductive element positioned adjacent to the base. The positive of the predetermined pattern of features may include a multiplicity of nano-sized features.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: November 17, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: James Zhu, Daniel M. Lentz, Karl K. Stensvad, David J. Tarnowski
  • Patent number: 10765093
    Abstract: This present invention relates to transgenic animals useful to study human diseases. Specifically, the invention relates to transgenic animals expressing at least two human proteins (optionally in replacement of the counterpart proteins in the animal) whereas a first human protein interacts with a second human protein. The transgenic animals can then be used for evaluating drugs or building disease models that are related to the expressed human proteins in the animals. The animals and methods disclosed herein reduce the possibility identifying a false-positive compound—the compound that show an effect in a naturally-occurring, non-transgenic animal but may not necessarily work or be therapeutic in human, since the compound may only interrupt the interaction between two animal proteins not necessarily two related human proteins.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 8, 2020
    Inventor: James Zhu
  • Publication number: 20200105440
    Abstract: A stretchable conductor includes a substrate with a first major surface and an elongate wire, wherein the substrate is an elastomeric material, the elongate wire is on the first major surface of the substrate, the wire includes a first end and a second end, and further includes at least one arcuate region between the first end and the second end. At least one portion of the arcuate region of the wire in the region has a first surface area portion embedded in the surface of the substrate and a second surface area portion unembedded on the substrate and exposed in an amount sufficient to render at least an area of the substrate in the region electrically conductive. The unembedded second surface portion of the arcuate region may lie above or below a plane of the substrate. Additionally, different methods of preparing said stretchable conductor are disclosed. Composite articles including said stretchable conductor in durable electrical contact with a conductive fabric are also disclosed.
    Type: Application
    Filed: June 7, 2018
    Publication date: April 2, 2020
    Inventors: Ankit Mahajan, Jr., James Zhu, Saagar A. Shah, Mikhail L. Pekurovsky, Vivek Krishnan, Kevin T. Reddy, Christopher B. Walker, Jr., Michael A. Kropp, Kara A. Meyers, Teresa M. Goeddel, Thomas J. Metzler, Jonathan W. Kemling, Roger W. Barton
  • Publication number: 20190273061
    Abstract: Processes for automatic registration between a solid circuit die and electrically conductive interconnects, and articles or devices made by the same are provided. The solid circuit die is disposed on a substrate with contact pads aligned with channels on the substrate. Electrically conductive traces are formed by flowing a conductive liquid in the channels toward the contact pads to obtain the automatic registration.
    Type: Application
    Filed: November 16, 2017
    Publication date: September 5, 2019
    Inventors: Ankit Mahajan, Mikhail L. Pekurovsky, Matthew S. Stay, Daniel J. Theis, Ann M. Gillman, Shawn C. Dodds, Thomas J. Metzler, Matthew R.D. Smith, Roger W. Barton, Joseph E. Hernandez, Saagar A. Shah, Kara A. Meyers, James Zhu, Teresa M. Goeddel, Lyudmila A. Pekurovsky, Jonathan W. Kemling, Jeremy K. Larsen, Jessica Chiu, Kayla C. Niccum
  • Publication number: 20190219919
    Abstract: A method of patterning a cylindrical tool, including providing a stamp including a base and a layer of solid state ionic conductor thereon, applying a negative of a predetermined pattern of features on a major surface of the solid state ionic conductor, providing a cylindrical tool having a metallic surface positioned proximate the stamp, and applying an electric field between the metallic surface and a cathode while moving the stamp against the metallic surface in rolling line contact so as to impart the predetermined pattern of features onto the metallic surface, wherein the cathode is either the base or a conductive element positioned adjacent to the base. The positive of the predetermined pattern of features may include a multiplicity of nano-sized features.
    Type: Application
    Filed: September 12, 2017
    Publication date: July 18, 2019
    Inventors: James Zhu, Daniel M. Lentz, Karl K. Stensvad, David J. Tarnowski
  • Publication number: 20190217324
    Abstract: Coating apparatuses and methods are provided for direct coatings with various shapes. The coating apparatus includes a die body with one or more bores. One or more cams are pivotally mounted within the bores and have one or more recessed areas formed into the respective peripheral surfaces thereof. The one or more cams are rotatable within the die body to dynamically, independently vary the width or shape of the respectively dispensed one or more fluid coatings.
    Type: Application
    Filed: May 15, 2017
    Publication date: July 18, 2019
    Inventors: Jonathan J. O'Hare, Karl K. Stensvad, Daniel H. Carlson, Glen A. Jerry, Mikhail L. Pekurovsky, Gary W. Maier, James Zhu
  • Patent number: 10137487
    Abstract: An apparatus for manufacturing a blade is provided. The apparatus for manufacturing a blade includes: an arm module including a pressing unit pivoting around a first shaft; a molding module including a molding die pressed by the pressing unit and molding bulk metallic glass (BMG) to a blade; and a drawing module pulling an end portion of the BMG exposed to the outside of the molding die to form an edge of the blade, wherein the drawing module includes a pair of drawing tools pulling one end portion of the BMG in two directions.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: November 27, 2018
    Assignee: KOREA INSTITUTE OF MACHINERY & MATERIALS
    Inventors: Jong-Kweon Park, Seung Kook Ro, Sung Cheul Lee, Shiv G. Kapoor, James Zhu
  • Publication number: 20180305686
    Abstract: The present disclosure is directed to a novel, unexpected approach of expressing exogenous gene(s) at increased levels by predictably, optionally irreversibly, incorporating the gene(s) into a region of increased gene expression (RIDGE) on a chromosome of a host cell. This approach is accomplished by identification of RIDGE(s). and further by integration of integrase-specific sites (e.g., attP or attB) in the presence of or mediated by integrase. The approach renders a high level of gene expression; predictability of the location of the exogenous genes, elimination of genetic instability or unwanted phenotype; and reduction of time and cost in optimizing protein production in host cells, which will be every useful in the production of therapeutic, prophylactic, and diagnostic proteins.
    Type: Application
    Filed: November 26, 2015
    Publication date: October 25, 2018
    Inventors: James ZHU, Guoliang YU
  • Patent number: 10060915
    Abstract: The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: August 28, 2018
    Assignee: NVIGEN, INC.
    Inventors: Aihua Fu, James Zhu
  • Publication number: 20170362580
    Abstract: The present disclosure provides novel compositions and methods suitable for specifically eliminating target cells (e.g., cancer cells) without affecting non-target cells (e.g., non-cancer cells). For example, CR-ISPR system and the compositions of the present disclosure can be employed to specifically introduce a suicidal gene into a cancer cell in the loci of a cancer-specific target sequence, which as a result of chromosomal re-arrangement or translocation in a cancer cell presents a cancer specific sequence for a guide RNA and CAS to be recognized and such sequence is absent in a non-cancer cell. Consequently, the specific introduction of the composition(s) to cancer-specific site(s) and integration of suicide gene in the target genome, which is inapplicable to normal cells for lack of the site(s), leads to selective elimination of cancer cells but not non-cancer cells, and therefore render novel therapeutic methods and compositions for cancer treatment.
    Type: Application
    Filed: December 14, 2015
    Publication date: December 21, 2017
    Inventor: James Zhu
  • Patent number: 9708660
    Abstract: The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in DNA amplification, detection, and DNA sequencing.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: July 18, 2017
    Assignee: NVIGEN, INC.
    Inventors: Aihua Fu, James Zhu
  • Publication number: 20170120468
    Abstract: An apparatus for manufacturing a blade is provided. The apparatus for manufacturing a blade includes: an arm module including a pressing unit pivoting around a first shaft; a molding module including a molding die pressed by the pressing unit and molding bulk metallic glass (BMG) to a blade; and a drawing module pulling an end portion of the BMG exposed to the outside of the molding die to form an edge of the blade, wherein the drawing module includes a pair of drawing tools pulling one end portion of the BMG in two directions.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 4, 2017
    Inventors: Jong-Kweon PARK, Seung Kook Ro, Sung Cheul Lee, Shiv G. Kapoor, James Zhu
  • Patent number: 9234195
    Abstract: The present disclosure is directed to a novel, unexpected approach of expressing exogenous gene(s) at increased levels by predictably, optionally irreversibly, incorporating the gene(s) into a region of increased gene expression (RIDGE) on a chromosome of a host cell. This approach is accomplished by identification of RIDGE(s) and further by integration of integrase-specific sites (e.g., attP or attB) in the presence of or mediated by integrase. The approach renders a high level of gene expression; predictability of the location of the exogenous genes, elimination of genetic instability or unwanted phenotype; and reduction of time and cost in optimizing protein production in host cells, which will be every useful in the production of therapeutic, prophylactic, and diagnostic proteins.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: January 12, 2016
    Assignee: APPLIED STEMCELL, INC.
    Inventors: James Zhu, Guoliang Yu
  • Patent number: 9151369
    Abstract: Disclosed is an aerostatic air bearing. The disclosed aerostatic air bearing includes: an aerostatic nut, said aerostatic nut including a housing having an air inlet disposed therein, a helical plenum chamber disposed in said housing, said helical plenum chamber being fluidly connected to the air inlet and fluidly interconnecting a plurality of openings, said openings being disposed in a helical pattern, and a plurality of porous media, each of said porous media being disposed in one of the plurality of openings respectively; and a lead screw coupled to said aerostatic nut, said lead screw including a threaded surface separated from each of the plurality of porous media.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: October 6, 2015
    Assignee: KOREA INSTITUTE OF MACHINERY & MATERIALS
    Inventors: Jong-Kweon Park, Seung Kook Ro, Gyung Ho Khim, Shiv G. Kapoor, James Zhu
  • Publication number: 20150051102
    Abstract: The present disclosure provides compositions and methods useful for molecular and cellular separation, detection and quantification. The compositions provided herein comprise a nanostructure having magnetic property operably linked to an analyte-binding member.
    Type: Application
    Filed: April 1, 2013
    Publication date: February 19, 2015
    Inventors: Aihua Fu, James Zhu
  • Publication number: 20150031575
    Abstract: The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in DNA amplification, detection, and DNA sequencing.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 29, 2015
    Inventors: Aihua Fu, James Zhu
  • Publication number: 20140366663
    Abstract: Disclosed is an aerostatic air bearing. The disclosed aerostatic air bearing includes: an aerostatic nut, said aerostatic nut including a housing having an air inlet disposed therein, a helical plenum chamber disposed in said housing, said helical plenum chamber being fluidly connected to the air inlet and fluidly interconnecting a plurality of openings, said openings being disposed in a helical pattern, and a plurality of porous media, each of said porous media being disposed in one of the plurality of openings respectively; and a lead screw coupled to said aerostatic nut, said lead screw including a threaded surface separated from each of the plurality of porous media.
    Type: Application
    Filed: June 17, 2013
    Publication date: December 18, 2014
    Inventors: Jong-Kweon PARK, Seung Kook Ro, Gyung Ho Khim, Shiv G. Kapoor, James Zhu
  • Publication number: 20130252830
    Abstract: The present disclosure is directed to a novel, unexpected approach of expressing exogenous gene(s) at increased levels by predictably, optionally irreversibly, incorporating the gene(s) into a region of increased gene expression (RIDGE) on a chromosome of a host cell. This approach is accomplished by identification of RIDGE(s) and further by integration of integrase-specific sites (e.g., attP or attB) in the presence of or mediated by integrase. The approach renders a high level of gene expression; predictability of the location of the exogenous genes, elimination of genetic instability or unwanted phenotype; and reduction of time and cost in optimizing protein production in host cells, which will be every useful in the production of therapeutic, prophylactic, and diagnostic proteins.
    Type: Application
    Filed: November 25, 2011
    Publication date: September 26, 2013
    Applicant: APPLIED STEMCELL, INC.
    Inventors: James Zhu, Guoliang Yu