Patents by Inventor Jamey Wierzbowski

Jamey Wierzbowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9155792
    Abstract: The present invention is directed to the use of RecA inhibitors as antibiotic agents, and provides RecA inhibitors useful in treating infections. Also provided are various compositions and methods associated with RecA inhibition.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: October 13, 2015
    Assignee: Trustees of Boston University
    Inventors: Guillaume Cottarel, Jamey Wierzbowski, Kollol Pal, Michael Kohanski, Daniel Dwyer, James Collins, Michael Almstetter, Michael Thormann, Andreas Treml
  • Publication number: 20100234348
    Abstract: The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.
    Type: Application
    Filed: August 2, 2007
    Publication date: September 16, 2010
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Guillaume Cottarel, Timothy S. Gardner, Xiaoguang Lei, John Porco, Scott E. Schaus, Jamey Wierzbowski, Kollol Pal
  • Publication number: 20100029597
    Abstract: The present invention is directed to the use of RecA inhibitors as antibiotic agents, and provides RecA inhibitors useful in treating infections. Also provided are various compositions and methods associated with RecA inhibition.
    Type: Application
    Filed: February 13, 2007
    Publication date: February 4, 2010
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, PURETECH VENTURES
    Inventors: Guillaume Cottarel, Jamey Wierzbowski, Kollol Pal, Michael Kohanski, Daniel Dwyer, James Collins, Michael Almstetter, Michael Thormann, Andreas Treml
  • Publication number: 20100028334
    Abstract: A pharmaceutical composition comprising an antimicrobial agent and an enhancer of an antimicrobial agent, wherein the enhancer of an antimicrobial agent is an inhibitor of gene, that by inactivating the gene product potentiates the effectiveness of the antimicrobial agent. In some embodiments, the pharmaceutical composition further comprises a pharmaceutically acceptable carrier. In some embodiments, the antimicrobial agent is an antimicrobial peptide such as a polymyxin, for example but not limited to colistin. In some embodiments of the present invention provides methods to treat and/or prevent infection of a subject with a microorganism by administering a pharmaceutical composition comprising an antimicrobial agent and an enhancer of an antimicrobial agent. In some embodiments, the present invention provides methods to inhibit growth of a microorganism by administering a pharmaceutical composition comprising an antimicrobial agent and an enhancer of an antimicrobial agent.
    Type: Application
    Filed: December 13, 2007
    Publication date: February 4, 2010
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Guillaume Cottarel, Jamey Wierzbowski
  • Publication number: 20090264342
    Abstract: The present invention provides methods for identifying target genes whose partial or complete functional inactivation potentiates the activity of an antibiotic agent, e.g., a quinolone antibiotic. The invention further provides methods for identifying agents that modulate expression of target genes or that modulate activity of expression products of target genes. Agents identified according to various methods of the invention potentiate the activity of antibiotics such as quinolones, aminoglycosides, peptide antibiotics and ?-lactams. Also provided are agents that suppress and/or retard resistance to antibiotics. The inventive methods provide potentiating agents and compositions comprising potentiating agents and antibiotics. Such agents and compositions can be used for inhibiting growth or survival of a microbial cell or of treating a subject suffering from or susceptible to a microbial infection.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 22, 2009
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, PURETECH VENTURES
    Inventors: Guillaume Cottarel, Jamey Wierzbowski, Kollol Pal, Michael Kohanski, Daniel Dwyer, James Collins, Michael Almstetter, Michael Thormann, Andreas Treml