Abstract: Arranged in an examination room is a CT installation which can travel along a predetermined travel path between two installation limit positions. Arranged on the CT installation is a telescopic rod, which extends from a hinge point that is proximal with respect to the CT installation to a hinge point that is distal with respect to the CT installation. The telescopic rod is rotatably mounted in the two hinge points, and can telescope between a minimum length and a maximum length. Arranged on the telescopic rod (6) are a number of retaining elements that can travel along the telescopic rod. A number of lines are guided via the retaining elements, so that when the telescopic rod is of minimum length, the lines are guided in serpentine loops.

Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.

Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.

Abstract: Arranged in an examination room is a CT installation which can travel along a predetermined travel path between two installation limit positions. Arranged on the CT installation is a telescopic rod, which extends from a hinge point that is proximal with respect to the CT installation to a hinge point that is distal with respect to the CT installation. The telescopic rod is rotatably mounted in the two hinge points, and can telescope between a minimum length and a maximum length. Arranged on the telescopic rod (6) are a number of retaining elements that can travel along the telescopic rod. A number of lines are guided via the retaining elements, so that when the telescopic rod is of minimum length, the lines are guided in serpentine loops.

Abstract: A method of material flow optimization in an industrial process by using an integrated optimizing system is described. The integrated optimizing system includes: a high-level optimizer module describing the material flow by coarse high-level process parameters and including an optimization program for the high-level process parameters, the optimization program being dependent on high-level model parameters and including an objective function subject to constraints; a low-level simulation module for simulating the material flow, the low-level simulation module including a low-level simulation function adapted for obtaining detailed low-level material flow data based on the high-level process parameters; and an aggregator module including an aggregator function adapted for calculating the high-level model parameters based on the low-level material flow data.

Abstract: The present invention discloses an ionization apparatus 10 for ionizing an analyte S, comprising an inlet E, an outlet A, a first electrode 1, a second electrode 2 and a dielectric element 3. The first electrode 1, the second electrode 2 and the dielectric element 3 are arranged relative to one another such that, by applying an electric voltage between the first electrode 1 and the second electrode 2, a dielectric barrier discharge is establishable in a discharge area 5 in the ionization apparatus 10. The first and second electrodes 1, 2 are arranged such that they are displaceable or movable relative to each other.

Abstract: A method for monitoring a continuous industrial process is described. The industrial process includes a number of processing stations for processing material and a material flow between the number of processing stations. Each processing station dynamically provides data representing a state of the processing station. The method includes providing, for each processing station, a processing station layout of the processing station. The method further includes providing, for each processing station, an interface model of the processing station. The method further includes generating an information metamodel from the processing station layout and the interface model of the number of processing stations. The method further includes generating an adaptive simulation model of the industrial process by importing the data representing the state of the processing station provided by the number of processing stations into the adaptive simulation model via the information metamodel.

Abstract: A method of industrial processing of a bulk material, the industrial processing including a plurality of process steps, the method including defining a material portion of the bulk material; generating a material portion identifier associated with the material portion processing the material portion in at least two process steps of the plurality of process steps the method including for each process step of the at least two process steps: determining a cost of processing the material portion in the process step; and generating a history data set, wherein the history data set is indicative of the cost, the process step and the material portion identifier and wherein the method further includes determining an aggregated cost based on the history data sets.

Abstract: Methods, devices, and assemblies for controlling pressure in a supply grid are provided. The supply grid is suitable for supplying fluid to loads. The supply grid has first sensors for measuring the flow and/or the pressure of the fluid at first locations in the supply grid and a pump for pumping the fluid or a valve for controlling the flow of the fluid. The method includes: measuring the flow and/or pressure of the fluid at the first locations in the supply grid by the first sensors; predicting the pressure at the second location in the supply grid using a self-learning system based on the measured flows or pressures, wherein the self-learning system is trained to predict the pressure at a specified location in the supply grid; and actuating the pump or the valve at least also based on the pressure predicted by the trained system at the second location.

Abstract: The invention relates to a method for operating a climate-control system (12) for a vehicle (10). According to the invention, total energy efficiencies are determined for a group of operating strategies for the air-conditioning system (12) and an operating strategy with the greatest total efficiency that fulfills the heating output requirement (44) that has been determined, is selected.

Abstract: A training data generator includes an interface to read symbols extracted from digital system plans for technical systems, wherein each of the system plans represents the design and/or the functionality of a technical system by of symbols, and the system plans are identical. The training data generator also includes a storage module which is designed to store the extracted symbols, a selection module which is designed to randomly select a symbol sub-quantity of the stored symbols using a random generator, a generator which is designed to generate at least one synthetic system plan on the basis of the selected symbol sub-quantity, and an output module to output the at least one synthetic system plan as training data in order to train a trainable image detection module, wherein the trainable image detection module is designed to generate a digital system plan using an analog system plan of a technical system.

Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.

Abstract: In order to provide a method for de-icing a heat exchanger of a motor vehicle, which prevents large amounts of melt water from a defrosting process running onto the floor or the road beneath the motor vehicle, freeze again and pose a risk of injury to pedestrians, in a method for defrosting a heat exchanger of a motor vehicle, in which, for a heat exchanger arranged in a motor vehicle, a defrosting process for removing a layer of frozen water or frost formed on a surface of the heat exchanger is carried out, the defrosting process comprising heating the surface, and melt water being produced, it is proposed that the amount of melt water discharged onto a local region of a floor beneath the motor vehicle is limited to a maximum value.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: A fuel cell system includes a combined cooling circuit for a motor vehicle that provides a method of cooling a fuel cell of a fuel cell system.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: A mobile computed tomography system has a gantry with an opening for at least partially accommodating a patient, and a carriage configured to be moved over a substrate with motor assistance. The gantry is arranged on an upper side of a support frame of the carriage. The support frame includes at least one shaped profile tube.

Abstract: A computer-implemented method of generating a training data set for training an artificial intelligence module includes providing first and second data sets, the first data set including first data elements indicative of a first operational condition, the second data set including second data elements indicative of a second operational condition that matches the first operational condition. The method further comprises determining a data transformation for transforming the first data elements into the second data elements; applying the data transformation to the first data elements and/or to further data elements of further data sets, thereby generating a transformed data set; and generating a training data set for training the AI module based on at least a part of the transformed data set.

Abstract: A process for producing decaffeinated green coffee beans, decaffeinated roasted coffee beans or preparations produced therefrom is described, wherein one process step comprises the PEF (pulsed electric field) treatment of (optionally presoaked) green coffee beans. Also described is a decaffeinated green coffee bean, a decaffeinated roasted coffee bean, and a preparation produced therefrom, and also the use of a PEF device for the treatment of (optionally presoaked) green coffee beans. A system for decaffeinating green coffee beans is additionally described.

Abstract: A method of transfer learning for a specific production process of an industrial plant includes providing data templates defining expected data for a production process, and providing plant data, wherein the data templates define groupings for the expected data according to their relation in the industrial plant; determining a process instance and defining a mapping with the plant data; determining historic process data; determining training data using the determined process instance and the determined historic process data, wherein the training data comprises a structured data matrix, wherein columns of the data matrix represent the sensor data that are grouped in accordance with the data template and wherein rows of the data matrix represent timestamps of obtaining the sensor data; providing a pre-trained machine learning model using the determined process instance; and training a new machine learning model using the provided pre-trained model and the determined training data.