Abstract: A cover for sealing a container and preferably containers for a well plate. The cover is comprised of at least a top layer and a bottom layer structured in a way to form a recloseable aperture. Preferably, each of the layers comprise a recloseable aperture structured as flap, damper, baffle or butterfly valve respectively, wherein the recloseable apertures are arranged on top of each other. In a preferred embodiment of the invention a third moveable layer is arranged between the top and the bottom layer. By moving the middle layer, the aperture in the cover can be closed.

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract: A microfluidic device comprising at least one inlet port, at least one flow path coupled to the inlet port, and at least one fluid separation element coupled to the flow path, wherein the fluid separation element comprises a packing material and is adapted for separating different components of a fluid, wherein the microfluidic device comprises at least one retaining device for keeping the packing material of the fluid separation element fixed in place and protecting the microfluidic device from debris polluting the analyte.

Abstract: A cover for sealing a container and preferably containers for a well plate. The cover is comprised of at least a top layer and a bottom layer structured in a way to form a recloseable aperture. Preferably, each of the layers comprise a recloseable aperture structured as flap, damper, baffle or butterfly valve respectively, wherein the recloseable apertures are arranged on top of each other. In a preferred embodiment of the invention a third movable layer is arranged between the top and the bottom layer. By moving the middle layer, the aperture in the cover can be closed.

Abstract: A microfluidic chip with at least one inlet port, with at least one microfluidic flow path coupled to the inlet port, and with at least one analytical element adapted for analyzing and/or separating components of a liquid within the flow path which is arranged within or adjacent to, and/or is coupled to the microfluidic flow path. The microfluidic chip is adapted to execute at least two processes in parallel.