Abstract: A two-wheeler pneumatic tire, in which damage protection and puncture protection are improved while providing good rolling resistance and good tightness; the two-wheeler pneumatic tire in the bead regions has a protective layer which is disposed axially outside the carcass and which has strength members embedded in rubber material; wherein the tire carcass is formed from a first carcass ply and a second carcass ply disposed radially within in a vertex, and wherein the second carcass ply ends with a second carcass ply turn-up in a second carcass ply end in the bead region; the purpose of damage protection and puncture protection is achieved in that the first carcass ply is guided from the respective bead region in a first carcass ply turn-up over the respective tire sidewall to below the tread and at the latter ends in each case in a first carcass ply end; and that in each of the two axial halves the protective layer is guided from the bead region over the respective tire sidewall to below the tread.