Patents by Inventor Janet Anne Halliday
Janet Anne Halliday has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220040094Abstract: The present invention is based on the identification of a cohort of polyurethane block copolymers that are particularly suited for use in pharmaceutical polymeric drug-device units and which offer improved control of drug release. In particular, there is provided a polymeric drug-device unit comprising a polyurethane block copolymer obtainable by reacting together a poly(alkylene oxide); a difunctional compound; a difunctional isocyanate; and optionally a block copolymer comprising poly(alkylene oxide) blocks; and quinagolide as a pharmaceutically active agent. The drug-device units may find application in the treatment and/or prevention of endometriosis.Type: ApplicationFiled: May 10, 2021Publication date: February 10, 2022Applicant: Ferring B.V.Inventors: Janet Anne HALLIDAY, Denis Andrew CARR, Alistair Chassels ROSS, Claire Donaldson YOUNG, Paul MCDONALD, Mohammad Siddique QADIR, Robert Victor COCHRANE, Gouher RABANI, Joan Carles ARCE SAEZ, Axel Niclas PETRI
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Patent number: 10105445Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.Type: GrantFiled: February 6, 2015Date of Patent: October 23, 2018Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Alexander Livingstone, Janet Anne Halliday
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Patent number: 9987364Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: GrantFiled: December 6, 2013Date of Patent: June 5, 2018Assignee: Ferring B.V.Inventors: Janet Anne Halliday, Jukka Tuominen, Mark Alexander Livingstone, Frank Koppenhagen, Lilias Morton Currie, Sarah Stewart
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Publication number: 20180008535Abstract: The present invention is based on the identification of a cohort of polyurethane block copolymers that are particularly suited for use in pharmaceutical polymeric drug-device units and which offer improved control of drug release. In particular, there is provided a polymeric drug-device unit comprising a polyurethane block copolymer obtainable by reacting together a poly(alkylene oxide); a difunctional compound; a difunctional isocyanate; and optionally a block copolymer comprising poly(alkylene oxide) blocks; and quinagolide as a pharmaceutically active agent. The drug-device units may find application in the treatment and/or prevention of endometriosis.Type: ApplicationFiled: November 5, 2015Publication date: January 11, 2018Inventors: Janet Anne Halliday, Denis Andrew Carr, Alistair Chassels Ross, Claire Donaldson Young, Paul McDonald, Mohammad Siddique Qadir, Robert Victor Cochrane, Gouher Rabani, Joan Carles Arce Saez, Axel Niclas Petri
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Publication number: 20150165044Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.Type: ApplicationFiled: February 6, 2015Publication date: June 18, 2015Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Alexander Livingstone, Janet Anne Halliday
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Patent number: 8974813Abstract: A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4,000, an aliphatic diol, and a difunctional diisocyanate. Controlled release composition comprises the polymer together with an active agent. The polymer is able to take up pharmaceutically active agents of molecular weight 200 to 20,000.Type: GrantFiled: June 27, 2007Date of Patent: March 10, 2015Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Publication number: 20140107195Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: ApplicationFiled: December 6, 2013Publication date: April 17, 2014Applicant: Ferring B.V.Inventors: Janet Anne Halliday, Jukka Tuominen, Mark Alexander Livingstone, Frank Koppenhagen, Lilias Morton Currie, Sarah Stewart
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Patent number: 8524254Abstract: A bioresorbable polymer is obtained by reacting together (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties; (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C2-C6 diol; and (c) a diisocyanate. The polymer may be loaded with a pharmaceutically active agent to produce a drug delivery device.Type: GrantFiled: October 15, 2007Date of Patent: September 3, 2013Assignee: Ferring B.V.Inventors: Donald Magnus Nicolson, Janet Anne Halliday, Jukka Tuominen, Amaia Zurutuza
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Patent number: 8361272Abstract: A linear polymer is obtained by reacting together a polyethylene glycol or polypropylene glycol; a PEG-PPG-PEG or PPG-PEG-PPG block copolymer; a difunctional amine or diol; and a diisocyanate. A controlled release composition comprises the polymer together with an active agent. Active agents of molecular weight 200 to 20,000 may be used.Type: GrantFiled: June 27, 2007Date of Patent: January 29, 2013Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Publication number: 20120329883Abstract: This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.Type: ApplicationFiled: September 6, 2012Publication date: December 27, 2012Inventors: Jukka Tuominen, AMAIA ZURUTUZA, MARK LIVINGSTONE, JANET ANNE HALLIDAY
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Publication number: 20100317745Abstract: A bioresorbable polymer is obtained by reacting together (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties; (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C2-C6 diol; and (c) a diisocyanate. The polymer may be loaded with a pharmaceutically active agent to produce a drug delivery device.Type: ApplicationFiled: October 15, 2007Publication date: December 16, 2010Inventors: Donald Magnus Nicolson, Janet Anne Halliday, Jukka Touminen, Amaia Zurutuza
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Publication number: 20080160065Abstract: One embodiment provides an insert, which includes a non-degradable hydrogel matrix and clindamycin hydrochloride in contact with the matrix, wherein the insert is suitable for mammalian intravaginal, buccal, or intrarectal use. Methods of using and making the insert are also provided.Type: ApplicationFiled: July 12, 2007Publication date: July 3, 2008Inventors: Janet Anne HALLIDAY, Denis Andrew CARR, Lynn BOYD, Monica MACGREGOR, Audrey THOM, Linda KELLY, Mark Alexander LIVINGSTONE, Lilias Morton CURRIE
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Patent number: 6488953Abstract: An autoadhesive oral transmucosal delivery device contains a pharmaceutically active agent which is delivered via mucosal tissues in the mouth. The device comprises a dry hydrogel polymer which autoadheres to the moist mucosal surface for a time sufficient for release of active agent to occur before becoming detached.Type: GrantFiled: June 1, 2001Date of Patent: December 3, 2002Assignee: Controlled Therapeutics (Scotland) Ltd.Inventors: Janet Anne Halliday, Steven Robertson
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Publication number: 20020037491Abstract: An autoadhesive oral transmucosal delivery device contains a pharmaceutically active agent which is delivered via mucosal tissues in the mouth. The device comprises a dry hydrogel polymer which autoadheres to the moist mucosal surface for a time sufficient for release of active agent to occur before becoming detached.Type: ApplicationFiled: June 1, 2001Publication date: March 28, 2002Inventors: Janet Anne Halliday, Steven Robertson