Patents by Inventor Janet L. Yother

Janet L. Yother has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5997882
    Abstract: Regions of the PspA protein of the R.times.1 strain of Streptococcus pneumoniae have been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S. pneumoniae strains and which is cross-protective. One region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the R.times.1 PspA strain while another region comprises the C-terminal amino acid sequence extending from amino acid residues 293 to 588 of the R.times.1 PspA strain.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 7, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother, Larry S. McDaniel
  • Patent number: 5980909
    Abstract: Regions of the PspA protein of the Rx1 strain of Streptococcus pneumoniae have been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S. pneumoniae strains and which is cross-protective. One region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA, another region comprises the C-terminal amino acid sequence extending from amino acid residues 293 to 588 of the Rx1 PspA, while a third region comprises the N-terminal amino acid sequence extending from amino acid residues 1 to 115 of the Rx1 PspA.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: November 9, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother, Larry S. McDaniel
  • Patent number: 5965141
    Abstract: A region of the PspA protein of the Rx1 strain of Streptococcus pneumoniae has been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S. pneumoniae strains and which is cross-protective. The region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA strain.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: October 12, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother, Larry S. McDaniel, Hong-Yin Wu
  • Patent number: 5965400
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: October 12, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5871943
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 16, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5856170
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 5, 1999
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5804193
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: September 8, 1998
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5753463
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 19, 1998
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5728387
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: March 17, 1998
    Assignee: University of Alabama at Birmingham Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5679768
    Abstract: A region of the PspA protein of the Rx1 strain of Streptococus pneumoniae has been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S.pneumoniae strains. The region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA strain.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 21, 1997
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother
  • Patent number: 5476929
    Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: December 19, 1995
    Assignee: UAB Research Foundation
    Inventors: David E. Briles, Janet L. Yother, Larry S. McDaniel