Patents by Inventor Janice A. Kolberg

Janice A. Kolberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6300056
    Abstract: Novel DNA probe sequences for detection of HIV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: October 9, 2001
    Assignee: Chiron Corporation
    Inventors: Bruce D. Irvine, Janice A. Kolberg, Michael S. Urdea
  • Patent number: 6297370
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: October 2, 2001
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Patent number: 6235465
    Abstract: Synthetic oligonucleotides which are useful as probes in a solution phase sandwich hybridization assay for the detection of HTLV-1 are described. The oligonucleotides have a first segment comprising a nucleotide sequence substantially complementary to a segment of HTLV-1 nucleic acid, and a second segment comprising a nucleotide sequence which is not complementary to HTLV-1 nucleic acid but is substantially complementary to an oligonucleotide unit of a nucleic acid multimer or to an oligonucleotide bound to a solid phase. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: May 22, 2001
    Assignee: Bayer Corporation
    Inventors: Janice A. Kolberg, Michael S. Urdea
  • Patent number: 6214583
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: April 10, 2001
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Patent number: 6190864
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: February 20, 2001
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Patent number: 6187538
    Abstract: This invention relates to a method of measuring the relative populations of first and second variants of a target nucleotide sequence of a target genome in a sample utilizing an amplification step, followed by probing with first and second variant probes and a control probe. Specific embodiments include an assay to monitor the conversion of codon 215 for HIV-1 reverse transcriptase from wild type to mutant form.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: February 13, 2001
    Assignee: Bayer Corporation
    Inventors: P. Scott Eastman, Michael S. Urdea, Janice A. Kolberg
  • Patent number: 6071693
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: June 6, 2000
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Patent number: 5856437
    Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: January 5, 1999
    Assignees: Chiron Corporation, The Director General of the National Institute of Health of Japan
    Inventors: Tatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine
  • Patent number: 5827648
    Abstract: This invention relates to a method of measuring the relative populations of first and second variants of a target nucleotide sequence of a target genome in a sample utilizing an amplification step, followed by probing with first and second variant probes and a control probe. Specific embodiments include an assay to monitor the conversion of codon 215 for HIV-1 reverse transcriptase from wild type to mutant form.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 27, 1998
    Assignee: Chiron Corporation
    Inventors: P. Scott Eastman, Michael S. Urdea, Janice A. Kolberg
  • Patent number: 5736316
    Abstract: Novel DNA probe sequences for detection of HBV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: April 7, 1998
    Assignee: Chiron Corporation
    Inventors: Bruce D. Irvine, Janice A. Kolberg, Joyce A. Running, Michael S. Urdea
  • Patent number: 5714596
    Abstract: A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers comprised of polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: February 3, 1998
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, George Kuo, Amy J. Weiner, Jang Han, Michael Steven Urdea, Bruce Duncan Irvine, Janice A. Kolberg
  • Patent number: 5712088
    Abstract: A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers containing polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: January 27, 1998
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, George Kuo, Amy J. Weiner, Jang Han, Michael Steven Urdea, Bruce Duncan Irvine, Janice A. Kolberg
  • Patent number: 5702891
    Abstract: Novel DNA probe sequences for detection of HAV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: December 30, 1997
    Assignee: Chiron Corporation
    Inventors: Janice A. Kolberg, Michael S. Urdea
  • Patent number: 5614362
    Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: March 25, 1997
    Assignee: Chiron Corporation
    Inventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn
  • Patent number: 5407795
    Abstract: Novel DNA probe sequences for detection of CMV in a sample in a solution phase sandwich hybridization assay are described. Amplified nucleic acid hybridization assays using the probes are exemplified.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: April 18, 1995
    Assignee: Chiron Corporation
    Inventors: Janice A. Kolberg, Lu-Ping Shen, Michael S. Urdea
  • Patent number: 5372928
    Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: December 13, 1994
    Assignees: Chiron Corporation, The Director General of the National Institute of Health of Japan
    Inventors: Tatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine
  • Patent number: 5359100
    Abstract: Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: October 25, 1994
    Assignee: Chiron Corporation
    Inventors: Michael S. Urdea, Brian Warner, Joyce A. Running, Janice A. Kolberg, Jennifer M. Clyne, Ray Sanchez-Pescador, Thomas Horn