Patents by Inventor Janusz Pawliszyn

Janusz Pawliszyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200355587
    Abstract: The present disclosure provides an apparatus for sampling at least one analyte from a sampling fluid. The apparatus includes: a solid-phase microextraction (SPME) sampling instrument. A connector is attached to the SPME sampling instrument and is coupleable to an aerial drone. The apparatus includes a protective cover that is sized and shaped to at least partially surround the SPME sampling instrument. The SPME sampling instrument and the protective cover are movable in relation to each other between a protecting configuration and a sampling configuration. The SPME sampling instrument and the protective cover are (i) biased in the protecting configuration when the density of the fluid surrounding the SPME sampling instrument is less than the density of the sampling fluid; and (ii) biased in the sampling configuration when the density of the fluid surrounding the SPME sampling instrument is equal to or greater than the density of the sampling fluid.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Inventor: Janusz PAWLISZYN
  • Patent number: 10393636
    Abstract: Disclosed herein is a system for desorbing and detecting an analyte sorbed on a solid phase microextraction (SPME) device. This SPME device The system includes a desorption chamber containing solvent required for desorption of analytes from SPME device; a flow injector in fluid connection with the desorption chamber, the desorption chamber and the flow injector being fluidly connected by at least a flow-insulating fluid connector; a solvent source in fluid connection with the flow injector; and a fluid switch that: in a desorption position, allows the solvent to be sprayed from the flow injector while flow-insulating any desorption solution in the desorption chamber, and in an detecting position, turns off the solvent source while maintaining the fluid connection between the flow injector and the desorption chamber, transferring the desorption solution through the flow-insulating fluid connector to the flow injector as a substantially undiluted plug of liquid.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 27, 2019
    Inventors: Janusz Pawliszyn, Marcos Tascon, Varoon Singh
  • Publication number: 20190003936
    Abstract: Disclosed herein is a system for desorbing and detecting an analyte sorbed on a solid phase microextraction (SPME) device. This SPME device The system includes a desorption chamber containing solvent required for desorption of analytes from SPME device; a flow injector in fluid connection with the desorption chamber, the desorption chamber and the flow injector being fluidly connected by at least a flow-insulating fluid connector; a solvent source in fluid connection with the flow injector; and a fluid switch that: in a desorption position, allows the solvent to be sprayed from the flow injector while flow-insulating any desorption solution in the desorption chamber, and in an detecting position, turns off the solvent source while maintaining the fluid connection between the flow injector and the desorption chamber, transferring the desorption solution through the flow-insulating fluid connector to the flow injector as a substantially undiluted plug of liquid.
    Type: Application
    Filed: June 7, 2018
    Publication date: January 3, 2019
    Inventors: Janusz Pawliszyn, Marcos Tascon, Varoon Singh
  • Patent number: 10033783
    Abstract: Disclosed are various embodiments for tracking media consumption by multiple devices. On a computing device, a first media consumption report is received. The first media consumption report is associated with a media title on a first client device. The first client device is registered by a user. A rights windows in a license associated with the media title is reconciled with the first media consumption report. Responsive to the reconciling, the reconciled license is propagated to the first client device.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: July 24, 2018
    Assignee: Amazon Technologies, Inc.
    Inventors: Siddharth Sriram, James Marvin Freeman, II, Michael Janusz Pawliszyn, Abhishek Prasad, Kamlesh T. Talreja
  • Patent number: 8104331
    Abstract: Applicants' teachings relate to a method and device to extract components contained in a fluid. More particularly, the applicants' teachings are directed towards a method and sampling device for quick extraction of targeted components from their in vivo surroundings. In accordance with various embodiments of applicants' teachings a sampling device and method to extract components, such as, for example, analytes, from a fluid is provided. The device is interfaced with a fluid source, such as, for example, but not limited to, a circulatory system of an animal, to enable extraction of target molecules with minimal loss of fluid (e.g., blood) to the source. The device facilitates an interface between the circulatory system of an animal and a suitable sampling probe such as, for example, a solid phase microextraction (SPME) probe. The targeted compounds are desorbed in small volumes of solvents that can be analyzed with highly specific instruments.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: January 31, 2012
    Assignees: Noab Biodiscoveries Inc.
    Inventors: Janusz Pawliszyn, Marcel Musteata, Ines Ana Maria De Lannoy, Kenneth Bradley Gien
  • Publication number: 20110104027
    Abstract: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living system.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 5, 2011
    Inventor: Janusz PAWLISZYN
  • Publication number: 20110067482
    Abstract: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring.
    Type: Application
    Filed: November 4, 2010
    Publication date: March 24, 2011
    Inventor: Janusz PAWLISZYN
  • Publication number: 20100011888
    Abstract: Applicants' teachings relate to a method and device to extract components contained in a fluid. More particularly, the applicants' teachings are directed towards a method and sampling device for quick extraction of targeted components from their in vivo surroundings. In accordance with various embodiments of applicants' teachings a sampling device and method to extract components, such as, for example, analytes, from a fluid is provided. The device is interfaced with a fluid source, such as, for example, but not limited to, a circulatory system of an animal, to enable extraction of target molecules with minimal loss of fluid (e.g., blood) to the source. The device facilitates an interface between the circulatory system of an animal and a suitable sampling probe such as, for example, a solid phase microextraction (SPME) probe. The targeted compounds are desorbed in small volumes of solvents that can be analyzed with highly specific instruments.
    Type: Application
    Filed: July 19, 2007
    Publication date: January 21, 2010
    Applicants: NOAB BIODISCOVERIES INC.
    Inventors: Janusz Pawliszyn, Marcel Musteata, Ines Ana Maria De Lannoy, Kenneth Bradley Gien
  • Publication number: 20070248500
    Abstract: An internally cooled solid phase microextraction device that provides for quantitative sampling of volatile and semi-volatile organic compounds in complex samples. The device temperature is controlled the device design enables repeated use without failure. The device is miniaturized allowing it to be used with autosamplers known in the art.
    Type: Application
    Filed: April 19, 2007
    Publication date: October 25, 2007
    Inventors: Janusz Pawliszyn, Yong Chen
  • Publication number: 20070148782
    Abstract: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.
    Type: Application
    Filed: February 15, 2007
    Publication date: June 28, 2007
    Inventor: Janusz Pawliszyn
  • Publication number: 20050287679
    Abstract: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.
    Type: Application
    Filed: August 23, 2005
    Publication date: December 29, 2005
    Inventor: Janusz Pawliszyn
  • Publication number: 20050276727
    Abstract: Multiwell plate applications are describe for use with a plurality of fibres having an extraction phase coated thereon in combination with a positioning device. The device and method described are able to perform adsorption of components of interest from a biological system in high volume.
    Type: Application
    Filed: August 19, 2005
    Publication date: December 15, 2005
    Inventors: Janusz Pawliszyn, Heather Lord, Marcel Musteata
  • Publication number: 20050118599
    Abstract: Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, LC/MS, MALDI and CE as well as direct spectroscopic on-fibre measurement.
    Type: Application
    Filed: March 6, 2003
    Publication date: June 2, 2005
    Inventor: Janusz Pawliszyn
  • Patent number: 6852206
    Abstract: Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation capillary was made of low refractive index Teflon conditioned with methylcellulose to reduce electroosmotic flow and a small amount of high refractive index organic solvent (glycerol) was added to the sample mixture. It was found that an axially directed laser excitation beam was propagated essentially with total internal reflection, so that minimum interference arose from stray light or from scattering light originating from the wall of the capillary. With the naturally fluorescent protein R-phycoerythrin, a concentration detection limit LOD 10?11 M or mass LOD 10?17 Mo was obtained.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: February 8, 2005
    Inventors: Janusz Pawliszyn, Xing-Zheng Wu, Tiemin Huang
  • Publication number: 20050014156
    Abstract: This invention relates to a micro cartridge and to a method of using the micro cartridge to sample and extract components of interest from a gas or a liquid. The cartridge contains a sorbent and has passages through which a pressure drop can be created to permit access between the gas or liquid and the sorbent. The micro cartridge is elongated and has one pointed end to fit into the injection port of a suitable analysis instrument where the components of interest are desorbed. The cartridge has two ends that are covered by removable closures and preferably has a diameter of less than 1 millimeter. The cartridge can be used with micro machine components and components made using nano technology.
    Type: Application
    Filed: November 26, 2002
    Publication date: January 20, 2005
    Inventor: Janusz Pawliszyn
  • Publication number: 20050011831
    Abstract: A device for carrying out solid phase microextraction on-site is a tubular member having one closed end and one open end with an extracting surface within said tubular member. The extracting surface can be an extracting phase coating extending over a zone within the tubular member. The tubular member is mounted in a housing with an airtight cavity. A method of operation of the device is also provided. The solid phase microextraction device facilitates the ultimate goal of chemist to perform analysis on-site at place where a sample is located rather than moving the sample to laboratory, as it is a common practice in many cases at present. This approach eliminates errors and reduces the time associated with sample transport and storage and, therefore, it results in more accurate, precise and faster analytical data.
    Type: Application
    Filed: June 29, 2004
    Publication date: January 20, 2005
    Inventor: Janusz Pawliszyn
  • Publication number: 20040191537
    Abstract: This invention relates to a stationary phase for solid phase microextraction (SPME) comprising a surface built up by a RAM (restricted access material) phase, a device for SPME comprising said stationary phase and a method for SPME using said stationary phase. The RAM SPME stationary phases according to the invention are robust, providing many direct extractions and subsequent determinations, while overcoming the present disadvantages of direct sampling of biological matrices by SPME.
    Type: Application
    Filed: December 10, 2003
    Publication date: September 30, 2004
    Inventors: Dieter Lubda, Christian Schafer, Janusz Pawliszyn, Wayne M Mullett
  • Publication number: 20010054554
    Abstract: Improved apparatus is disclosed for carrying out axially illuminated laser induced fluorescence whole-column imaging detection in the capillary isoelectric focusing of proteins. The separation capillary was made of low refractive index Teflon conditioned with methylcellulose to reduce electroosmotic flow and a small amount of high refractive index organic solvent (glycerol) was added to the sample mixture. It was found that an axially directed laser excitation beam was propagated essentially with total internal reflection, so that minimum interference arose from stray light or from scattering light originating from the wall of the capillary. With the naturally fluorescent protein R-phycoerythrin, a concentration detection limit LOD 10−11 M or mass LOD 10−17 Mo was obtained.
    Type: Application
    Filed: April 12, 2001
    Publication date: December 27, 2001
    Inventors: Janusz Pawliszyn, Xing-Zheng Wu, Tiemin Huang