Abstract: Embodiments disclosed herein concern various cells, co-cultures, methods, systems, therapies, and treatments involving in vitro and in vivo generation and use of functional mammalian thymic tissue, thymus organs, and thymic organoids. In certain embodiments, cells, tissues, and organoids disclosed herein can be used to treat a subject having a thymic condition. In other embodiments, thymic cells and organoids produced by compositions and methods disclosed herein can be used to treat various conditions, diseases, and disorders, including auto-immune disorders, transplant rejections, cancer, or aging.

Abstract: An overtube assembly for use with an elongate medical tool includes an overtube including a flexible tubular body having a proximal end and distal end. The flexible tubular body includes a split extending from the proximal end to the distal end. The overtube assembly further includes an inflatable balloon coupled to a distal portion of the flexible tubular body. The flexible tubular body is disposable over a section of the elongate medical tool by inserting the elongate medical tool through the split.

Abstract: A multi-unit packing system includes a packaging tray assembly supporting a medical device or product. The packaging tray assembly includes a tray that holds the medical product within a spring-loaded card. The spring-loaded card being disposed within the inner container of the tray. The spring-loaded card including a one or more openings that are positioned to maintain the medical product in a defined orientation while preventing the inadvertent movement of the medical product. The spring-loaded card comprises elastic properties to allow it to be elastically compressed when the barrier is sealed to the tray, and uncompressed when the barrier is peeled away from the tray, allowing a portion of the spring-loaded card to extend beyond a surface of the tray to provide easier access, removal and transfer of the sterile medical product within the sterile field.

Abstract: The disclosed technology includes methods, systems, and devices for generating patient-specific functional thymic epithelial progenitor (TEP) cells. In some implementations, a method may include generating iPSCs from HSC; causing differentiation of the iPSC into thymic epithelial progenitor (TEP) cells, generating thymic epithelial cells by transplantation of the TEP cells into a host, wherein the TEP cells may differentiate into mature functional thymic epithelial cells (TECs). In some implementations, a system may include a cell population of patient specific cells, a population of iPSCs, a culture system for differentiating the iPSCs into a population of patient-specific TEP cells for transfer to a host or the patient to allow the TEP cells to differentiate into mature, functional TEC.

Abstract: A multi-unit packing system includes a packaging tray assembly supporting a medical device or product. The packaging tray assembly includes a tray that holds the medical product within a spring-loaded card. The spring-loaded card being disposed within the inner container of the tray. The spring-loaded card including a one or more openings that are positioned to maintain the medical product in a defined orientation while preventing the inadvertent movement of the medical product. The spring-loaded card comprises elastic properties to allow it to be elastically compressed when the barrier is sealed to the tray, and uncompressed when the barrier is peeled away from the tray, allowing a portion of the spring-loaded card to extend beyond a surface of the tray to provide easier access, removal and transfer of the sterile medical product within the sterile field.

Abstract: An overtube assembly for use with an elongate medical tool includes an overtube including a flexible tubular body having a proximal end and distal end. The flexible tubular body includes a split extending from the proximal end to the distal end. The overtube assembly further includes an inflatable balloon coupled to a distal portion of the flexible tubular body. The flexible tubular body is disposable over a section of the elongate medical tool by inserting the elongate medical tool through the split.

Abstract: The invention relates to a metallocene complex according to the following formula (1) wherein R1 and R2 are the same or different and are a substituted or unsubstituted, linear or branched, hydrocarbyl group comprising 1 to 30 carbon atoms; M is titanium, zirconium, or hafnium and X1 and X2 are the same and are halogen or a hydrocarbyl group comprising 1 to 20 carbon atoms.

Abstract: The invention relates to a metallocene complex according to the following formula (1) wherein R1 and R2 are the same or different and are a substituted or unsubstituted, linear or branched, hydrocarbyl group comprising 1 to 30 carbon atoms; M is titanium, zirconium, or hafnium and X1 and X2 are the same and are halogen or a hydrocarbyl group comprising 1 to 20 carbon atoms.

Abstract: The present invention relates to an automatic injector having a drive assembly with an actuator extending from the rearward end portion of the housing and a removal resistant cover for preventing unintended operation of the actuator. The present invention also relates to a sealing arrangement wherein the needle is sealed within a sterilized needle chamber by at least three sealing members which cooperate to form the chamber. Also, the present invention relates to an injector in which the cartridge is mounted to a tubular cartridge mounting portion of the needle carrier with an annular sealing member disposed therebetween. The cartridge mounting portion has at least one generally axially extending groove which allows air to escape from the cartridge mounting portion as the cartridge is being moved forwardly to a medicament supplying position.