Abstract: The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.

Abstract: A printable medium support for a printer comprises a support element to support a printable medium, wherein the support element is movable between a protruding configuration to support the printable medium, and a retracted configuration in which the support element is at least partially retracted in a first direction. The printable medium support comprises an actuating element to move the support element between the protruding configuration and the retracted configuration.

Abstract: This document relates to orchestration and scheduling of services. One example method involves obtaining dependency information for an application. The dependency information can represent data dependencies between individual services of the application. The example method can also involve identifying runtime characteristics of the individual services and performing automated orchestration of the individual services into one or more application processes based at least on the dependency information and the runtime characteristics.

Abstract: A method for determining the level of contamination in cities comprising the steps of providing a server, transmitting information from users which report contamination issues by means of a mobile electronic device to the server, providing a wireless sensor network (WSN) for measuring level of contamination, obtaining measured data tagged with a geo-reference tag and a time stamp, and configured for supporting delay-tolerant communications transmitting data measured from sensors to the server, processing data measured and information from users by using big data and machine learning algorithms, and providing reports on contamination levels; and a system for collecting and processing environmental information comprising at least one mobile electronic device, including at least one environmental sensor, at least one wireless communication interface, a geo-location unit, and a storage unit; at least one communication gateway and at least a server for storing and processing the information obtained.

Abstract: A pressure and temperature measuring device with improved compact design and installation having a base (1) with an elongated geometry, arranged according to the longitudinal axis (A) inside the casing (16) and having a partition (5), a back (18), a platform (19) and a plinth (10); the partition (5) has an inner plane (5?) oriented towards the back (18) and parallel to the longitudinal axis (A) and an outer plane (5?) that forms an acute angle with the inner plane (5?), the back (18), the platform (19) and the inner plane (5?) of the partition (5) define a slot (17) and receives the electronic circuit board (3), the outer plane (5?) of the partition (5) defines a support surface to support together with the plinth (10) for the pressure-sensitive element (2), the outer surface (5?) of the partition (5) having an opening (7) that gives way to the conduit (8).

Abstract: A tubular retractor securement frame is disclosed including a mounting bracket, two flexor arms, and a device emplacement oriented to receive and hold in-place a surgical tool. The mounting bracket includes an elastically deformable plate, rails extending about orthogonal from the elastically deformable plate and about parallel to one another, and receptacles facing one another in the rails which are arranged to receive a retractor arm extending from a tubular retractor at a fixed angle. The flexor arms extend from the mounting bracket adjacent to the rails. The flexor arms are positioned so as not to occlude visualization through the tubular retractor and such that applying pressure to flex the flexor arms toward one another shifts the rails to accept or remove the retractor arm into or from the receptacles, and releasing the pressure reverts the rails so as to inhibit the retractor arm from being inserted or removed.

Abstract: A tubular retractor securement frame is disclosed including a mounting bracket, two flexor arms, and a device emplacement oriented to receive and hold in-place a surgical tool. The mounting bracket includes an elastically deformable plate, rails extending about orthogonal from the elastically deformable plate and about parallel to one another, and receptacles facing one another in the rails which are arranged to receive a retractor arm extending from a tubular retractor at a fixed angle. The flexor arms extend from the mounting bracket adjacent to the rails. The flexor arms are positioned so as not to occlude visualization through the tubular retractor and such that applying pressure to flex the flexor arms toward one another shifts the rails to accept or remove the retractor arm into or from the receptacles, and releasing the pressure reverts the rails so as to inhibit the retractor arm from being inserted or removed.

Abstract: A cutter assembly for a printable medium comprises a cutter to cut the printable medium, a trench adjacent to the cutter, and a trench cover, the trench cover at least partially covering the trench. The trench cover is movable between a supporting configuration to support the printable medium, and an open configuration to receive portions of the printable medium in the trench. The cutter assembly comprises an elastic element for biasing the trench cover towards the supporting configuration. The cutter comprises an engaging element and the engaging element engages the trench cover to move the trench cover from the supporting configuration towards the open configuration.

Abstract: A solid formulation including at least one 1,2,4-oxadiazole derivative of formula (I): wherein R1, R2, R3, R4 and R5 are each independently selected from hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy and C1-C3 thioalkyl; and citric acid and/or saccharin, wherein the molar ratio in the solid formulation between the total amount of citric acid and/or saccharin and the amount of the 1,2,4-oxadiazole derivative(s) ranges from about 2 to about 20. Also a process for manufacturing the solid composition and a method for increasing the physical stability of a 1,2,4-oxadiazole derivative of formula (I).

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A network repository function, NRF, in a core network domain of a mobile communication network is provided, wherein the NRF is configured to register network function, NF, profiles for NF discovery, and wherein NF certificates have been issued to the NFs, each NF certificate including a public key of the respective NF and at least one signature of at least one certification authority, CA. The NRF is configured to receive, from a registering NF having an NF certificate, profile information comprising an NF identity of the registering NF, an NF type of the registering NF, and at least one CA certificate of at least one CA that signed the NF certificate issued to the registering NF. The NRF is further configured to store the received profile information in a repository.

Abstract: The present invention relates to acquisition layers for use in absorbent articles, preferably of the disposable personal hygiene type. It discloses absorbent articles (7) comprising a liquid permeable topsheet (8), a liquid impermeable backsheet (9), an absorbent core (1) between the topsheet (8) and the backsheet (9) and an acquisition layer (2) between the topsheet (8) and the absorbent core (1), said acquisition layer (2) having a width (w) and a length (l) along an acquisition plane and a thickness (t) extending perpendicular thereto. The absorbent core (1) comprises at least one absorbent material selected from the group consisting of fibrous absorbent materials and highly absorbent polymers.

Abstract: The invention relates to a device and method for the simultaneous lyophilisation of a plurality of biological samples ensuring the traceability of said samples intended to be housed within coded containers (1); the device comprises a diffuser block (2) comprising a plurality of openings which define receptacles (21) to house the coded containers (1), wherein the diffuser block (2) further comprises a perimeter cavity (24) configured so that the alloy surrounding each receptacle (21) is similar in all the coded containers (1), enabling high thermal homogeneity, and the receptacles (21) have through openings defining an open bottom (23) to scan the coded containers (1). Likewise, the device further comprises a transfer lid (3) to ensure the position of each container (1) when it is transferred to the diffuser block (1) and back to the starting box (4).

Abstract: A system for use in monitoring one or more parameters of a subject's body is described. The system comprising: an illumination unit configured for providing pulsed coherent illumination and directing said illumination onto an inspected region on said subject's body; a collection unit configured for collecting light returning from said inspection region and generate a plurality of data pieces associated with secondary speckle patterns in said light; an external field stimulation unit configured for selectively generating external field stimulation onto the subject's body; and a control unit. The control unit is configured and operable for operating said illumination unit said collection unit and said external field stimulation unit and for receiving said plurality of data pieces from said collection unit to thereby determine said one or more conditions of the subject's body.

Abstract: The invention relates to an agricultural tool unit for the rapid conversion of a seed drill having a trailed or fine-grain seed dispenser with volumetric supply to an on-demand supply system and vice versa, which includes at least one hopper containing a granular feed material, such as grains, seeds or agrochemical granules, and a delivery device arranged under the hopper. This device has a structure that consists of two physically defined areas. One of the areas, hereinafter referred to as the “seed box”, has a direct connection to the hopper, receiving the granular material from same, generally gravity-fed, and another area, hereinafter referred to as the “air box”, which has a connection to an air source such as a fan or similar.

Abstract: The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.

Abstract: The present disclosure provides for albumin-binding prodrugs of auristatin E derivatives and uses thereof.

Abstract: The present invention provides a thermal image analyser for the analysis of the stomatal conductance s of a plant, which comprises a thermal imaging device, configured to capture a thermal image of at least a portion of the plant that is in an imaging region of the thermal imaging device, and a processor device, configured to analyse the captured thermal image and to determine the stomatal conductance of the plant on the basis of the captured thermal image. The thermal image analyser further comprises a reference object, which comprises a reference surface and a thermal sensor, wherein the thermal sensor is connected to the reference surface and configured to emit a sensor signal that is representative for a surface temperature of the reference surface. The reference object is adapted to be positioned, such that at least a portion of the reference surface is located in the imaging region of the thermal imaging device.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A concrete dowel slip tube assembly is provided for use in maintaining a planner consistency of a cured concrete slab formed on a support surface. The assembly comprises a plurality of elongate slip tubes, each having a length dimension and a tubular hollow interior compartment. Dowels are slidingly engageable to the hollow interior compartment to allow for translation along the interior compartment. A support frame defines a plurality of integral slip tube retaining members, disposed at evenly spaced locations along the support frame, the retaining members being configured to receive and engage associated slip tubes to the support frame in a common defined orientation. The support frame and the retaining members are formed as a unitary construction.