Patents by Inventor Javier Maria Peralta Ramos

Javier Maria Peralta Ramos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers for CNS Disease Modification
    Publication number: 20220146534
    Abstract: A method for predicting whether a patient diagnosed with a disease, disorder, condition or injury of the CNS is likely to be responsive or non-responsive to treatment with an immune checkpoint modulator is provided, wherein said method comprises determining ex vivo, in a blood sample obtained from the patient, or in a fraction thereof, a biomarker selected from: (a) the level of a monocyte subpopulation expressing CCR2, CD204 or a combination thereof, or CCR2 and a marker selected from igf1, lyve1, Stab-1, Siglec1 and Mrc1, or any combination thereof, (b) the ratio of the level of a monocyte subpopulation (CD14+ cells) expressing CCR2highCX3CR1low to a monocyte subpopulation expressing CCR2lowCX3CR1high; (c) the level of a CCR2 agonist; and (d) the level of a CCR2 antagonist.
    Type: Application
    Filed: January 16, 2020
    Publication date: May 12, 2022
    Applicant: Yeda Research and Development, Co., Ltd.
    Inventors: Michal Eisenbach-Schwartz, Hila Ben-Yehuda, Michal Arad, Tommaso Croese, Javier Maria Peralta Ramos, Giulia Castellani, Neta Rosenzweig