Patents by Inventor Jay Hyok Chang

Jay Hyok Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170253588
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: January 20, 2017
    Publication date: September 7, 2017
    Applicant: LG LIFE SCIENCES, LTD.
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20160264569
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: January 15, 2016
    Publication date: September 15, 2016
    Applicant: LG LIFE SCIENCES, LTD.
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20150291585
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: February 13, 2015
    Publication date: October 15, 2015
    Applicant: LG Life Sciences, LTD
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20140187576
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: October 25, 2013
    Publication date: July 3, 2014
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20130065917
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: June 26, 2012
    Publication date: March 14, 2013
    Inventors: Ae Ri KIM, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20110312987
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: April 11, 2011
    Publication date: December 22, 2011
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20100240694
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Ae Ri KIM, Jin Hwa LEE, Ki Sook PARK, Jong Ryoo CHOI, Tae Hee LEE, Jay Hyok CHANG, Do Hyun NAM, Hoon CHOI
  • Patent number: 7700617
    Abstract: A composition comprising 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate hydrate and their use in antibacterial therapy.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: April 20, 2010
    Assignee: LG Life Sciences, Ltd.
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Patent number: 7687629
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 30, 2010
    Assignee: LG Life Sciences Ltd.
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Hee Lee, Jae Sung Lee, Hyun-Kuk Noh
  • Patent number: 7576214
    Abstract: Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) in one-pot four steps using a single solvent.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: August 18, 2009
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun-Ik Shin, Jay-Hyok Chang, Kyu-Woong Lee
  • Publication number: 20090182006
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 16, 2009
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Publication number: 20070282107
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Application
    Filed: August 7, 2007
    Publication date: December 6, 2007
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Lee, Jae Lee, Hyun-Kuk Noh
  • Patent number: 7271272
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Grant
    Filed: March 6, 2004
    Date of Patent: September 18, 2007
    Assignee: LG Life Sciences Ltd.
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Hee Lee, Jae Sung Lee
  • Publication number: 20070021613
    Abstract: Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) inone-potfour stepsusing a single solvent.
    Type: Application
    Filed: October 22, 2004
    Publication date: January 25, 2007
    Inventors: Hyun-Ik Shin, Jay-Hyok Chang, Kyu-Woong Lee
  • Publication number: 20060264652
    Abstract: The present invention relates to a process for preparing 4-chloro-3-hydroxybutanoic acid ester, an intermediate for preparing atorvastatin, in high purity and yield, by comprising the steps of 1) reacting epichlorohydrin of formula (2) with cyanide of formula (3) under the condition of pH ranging from 7 to 8, to form the 4-chloro-3-hydroxybutyronitrile of formula (4) and 2a) dissolving the 4-chloro-3-hydroxybutyronitrile of formula (4) in an alcoholic solvent and reacting it with hydrogen chloride, or 2b) reacting the 4-chloro-3-hydroxybutyronitrile of formula (4) in an alcoholic solvent saturated with hydrogen chloride, to form the 4-chloro-3-hydroxybutyronitrile acid ester of formula (I).
    Type: Application
    Filed: April 14, 2004
    Publication date: November 23, 2006
    Inventors: Sung-Wook Cho, Jay-Hyok Chang, Kyu-Woong Lee, Ki-Kon Lee, Byung-Ran So, Hyun-Ik Shin
  • Publication number: 20060173195
    Abstract: The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
    Type: Application
    Filed: March 6, 2004
    Publication date: August 3, 2006
    Inventors: Gyo-Hyun Hwang, Yeong-Dae Kim, Hyun Nam, Jay-Hyok Chang, Hyun-Ik Shin, Young-Keun Kim, Kyung Lee, Jae Lee
  • Publication number: 20040198767
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Application
    Filed: April 15, 2004
    Publication date: October 7, 2004
    Applicant: LG Life Sciences, Ltd.
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Patent number: 6723734
    Abstract: 7-(3-Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: April 20, 2004
    Assignee: LG Life Sciences, Ltd.
    Inventors: Ae Ri Kim, Jin Hwa Lee, Ki Sook Park, Jong Ryoo Choi, Tae Hee Lee, Jay Hyok Chang, Do Hyun Nam, Hoon Choi
  • Patent number: 6630593
    Abstract: A process for preparing a 1-substituted 5-hydroxymethylimidazole of the formula: , wherein R represents alkyl, hydroxyalkyl, allyl, or substituted or unsubstituted arylmethyl or diarylmethyl, comprising the step of reacting a 1-substituted 2-mercapto-5-hydroxymethylimidazole of the formula: , wherein R is as defined above, in the presence of a transition metal catalyst and an oxidizing agent in a solvent.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: October 7, 2003
    Assignee: LG Chem Investment Ltd.
    Inventors: Hyun-Ik Shin, Jay-Hyok Chang, Kyoo-Woong Lee, Hyun-Il Lee, Sung-Kee Kim, Do-Hyun Nam
  • Patent number: 6559320
    Abstract: The present invention relates to a novel process for preparing pyrrole ester compounds, which are key intermediates in the preparation of farnesyl transferase inhibitors, an anti-cancer agent Horner-Emmons reaction of aldehyde compounds provides the corresponding &agr;,&bgr;-unsaturated esters, which without any separation and/or purification steps, are treated with toluenesutfonyl-methylisocyanate in the presence of base to give pyrrole esters in one-pot fashion.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: May 6, 2003
    Assignee: LG Chem Investment Ltd.
    Inventors: Hyun Ik Shin, Sung Tak Oh, Jay Hyok Chang, Kyoo Woong Lee