Patents by Inventor Jay M. Eastman

Jay M. Eastman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180263489
    Abstract: Optical sensors, systems and methods of use thereof are provided. Aspects of the subject systems include a sensor having a sensing surface and a configuration that directs a first optical signal to interact with the sensing surface at a first incident angle, and directs a second optical signal to interact with the sensing surface at a second incident angle. The subject sensors, systems and methods find use, e.g., in the diagnosis of dry eye disease.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 20, 2018
    Inventors: Paul T. Gavaris, Chris D. Geddes, Ali H. Ghovanlou, Jay M. Eastman, Zachary M. Eastman
  • Publication number: 20180085284
    Abstract: A device for stimulating the Meissner's Corpuscles along the front plantar portion of the foot or feet of a person is provided. The device has a platform disposed upon motion guides for movement up and down with respect to a base. The platform has a shaped surface for ease of placement of at least the front plantar portion of at least one foot of a person seated in front of the device in which the back or heel portion of the foot is disposed away from the device. One or more inertial actuators are attached to the platform underneath its surface. A controller controls operation of the actuator(s), via signals to a driver, to move the platform with respect to the base in a sinusoidally varying motion at a user selectable stimulation level. The stimulation level may be set wirelessly via an external device, or by manually tilting the device.
    Type: Application
    Filed: October 1, 2017
    Publication date: March 29, 2018
    Inventors: JAY M. EASTMAN, ZACHARY M. EASTMAN, SCOTT R. GRODEVANT
  • Patent number: 9775770
    Abstract: A device for stimulating the Meissner's Corpuscles along the front plantar portion of the foot or feet of a person is provided. The device has a platform disposed upon motion guides for movement up and down with respect to a base. The platform has a shaped surface for ease of placement of at least the front plantar portion of at least one foot of a person seated in front of the device in which the back or heel portion of the foot is disposed away from the device. One or more inertial actuators are attached to the platform underneath its surface. A controller controls operation of the actuator(s), via signals to a driver, to move the platform with respect to the base in a sinusoidally varying motion at a user selectable stimulation level. The stimulation level may be set wirelessly via an external device, or by manually tilting the device.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: October 3, 2017
    Assignee: VITAL MOTION INC.
    Inventors: Jay M. Eastman, Zachary M. Eastman, Scott R. Grodevant
  • Patent number: 9772486
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagable by a microscope through the window of the base member.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: September 26, 2017
    Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Publication number: 20160206501
    Abstract: A device for stimulating the Meissner's Corpuscles along the front plantar portion of the foot or feet of a person is provided. The device has a platform disposed upon motion guides for movement up and down with respect to a base. The platform has a shaped surface for ease of placement of at least the front plantar portion of at least one foot of a person seated in front of the device in which the back or heel portion of the foot is disposed away from the device. One or more inertial actuators are attached to the platform underneath its surface. A controller controls operation of the actuator(s), via signals to a driver, to move the platform with respect to the base in a sinusoidally varying motion at a user selectable stimulation level. The stimulation level may be set wirelessly via an external device, or by manually tilting the device.
    Type: Application
    Filed: November 17, 2014
    Publication date: July 21, 2016
    Inventors: JAY M. EASTMAN, ZACHARY M. EASTMAN, SCOTT R. GRODEVANT
  • Publication number: 20150277094
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible by a microscope through the window of the base member.
    Type: Application
    Filed: June 4, 2015
    Publication date: October 1, 2015
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Patent number: 9052523
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible by a microscope through the window of the base member.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: June 9, 2015
    Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Publication number: 20130182318
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen. The specimen retained in the cavity is imagible a microscope through the window of the base member.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 18, 2013
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Patent number: 8149506
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having an optically transparent window upon which a tissue specimen is situated, a membrane locatable over a substantial portion of the base member including the window, and an upper member which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. The edges of the tissue specimen may then be positioned planar against the window and retained in that position by bonds formed between the membrane and window around the tissue specimen. The cassette may be part of a confocal imaging system to produce microscopic images of sections of the tissue specimen useful for Mohs surgery.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 3, 2012
    Assignee: Lucii, Inc.
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Patent number: 7864996
    Abstract: A system for macroscopic and confocal imaging of tissue having a macroscopic imager for capturing a macroscopic image of the tissue's surface, a confocal imager for capturing one or more optically formed sectional microscopic images on or within tissue, a computer for receiving images from such imagers, and a tissue attachment device in which the macroscopic imager and confocal imager are each individually presented to the tissue utilizing the tissue attachment device in a predefined alignment, such that imaging locations of the confocal imager with respect to the tissue surface spatially correlate with macroscopic image. A user interface is operable on the computer to enable display of the macroscopic image on a display coupled to the computer, and to indicate a region within the macroscopic image associated with the field of view of the tissue imagable by the confocal imager.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: January 4, 2011
    Assignee: Lucid, Inc.
    Inventors: Paul Hemmer, Zachary M. Eastman, Jay M. Eastman, William J. Fox, James M. Zavislan
  • Patent number: 7813788
    Abstract: A handheld confocal imaging system for in vivo observation of dermal and subdermal tissue allows diagnosis of conditions substantially beneath the surface of the skin. A confocal head has optics which scan the tissue so as to provide images of vertical sections of the tissue. Both two and three dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: October 12, 2010
    Assignee: Lucid, Inc.
    Inventors: James M. Zavislan, Jay M. Eastman
  • Patent number: 7676258
    Abstract: A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of citric or other alpha-hydroxy acid which enhances tissue structures, such as cellular nuclei, in such images. Such concentration may be 3-20% acid, and preferably 5% acid.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: March 9, 2010
    Assignee: Lucid, Inc.
    Inventor: Jay M. Eastman
  • Patent number: 7139122
    Abstract: A system using cross polarization effects and an enhancement agent having citric or other similar alpha hydroxy acid to enhance confocal microscope reflectance images and particularly images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous cell carcinomas) in the confocal reflectance images of excised tumor slices obtained during Mohs surgery by illuminating the tissue being imaged (a tumor slice) using polarized light. The reflected illumination is passed to a polarization analyzer, which passes the polarization component which is crossed with respect to the polarization of the illuminating light. The light from the analyzer is passed through the confocal aperture and detected. The section of the tissue either at the surface or within the tissue is scanned and the reflectance image is produced with enhanced visualization of the cellular or nuclear structure thereof thereby enabling determination of the extent of the tumor (cancerous cells) in the section.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: November 21, 2006
    Assignee: Lucid, Inc.
    Inventors: Jay M. Eastman, Milind Rajadhyaksha, James M. Zavislan
  • Patent number: 7047064
    Abstract: An imaging apparatus is provided for imaging tissue samples substantially beneath the surface of the tissue sample. The apparatus includes an objective lens and a window defining a tissue contacting surface in pressure contacting relationship with the surface of the tissue sample when the tissue sample is imaged by the objective lens to view tissue structures for pathological applications. The objective lens focuses an illumination beam through the window to the tissue sample and receives returned reflected light of the beam representative of one or more sections of the tissue sample. The apparatus enables a method for in vivo observation of tissue for diagnosis of conditions substantially beneath the surface of the tissue sample. Both two and three-dimensional imaging may be provided for diagnosis and location of basal cell carcinomas and melanomas, and so as to enable visualization of tumor borders prior to excision.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: May 16, 2006
    Assignee: Lucid, Inc.
    Inventors: James M. Zavislan, Jay M. Eastman
  • Patent number: 7003345
    Abstract: A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of citric or other alpha-hydroxy acid which enhances tissue structures, such as cellular nuclei, in such images. Such concentration may be 3–20% acid, and preferably 5% acid.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: February 21, 2006
    Assignee: Lucid, Inc.
    Inventor: Jay M. Eastman
  • Patent number: 6816262
    Abstract: A colorimeter capable of calibrating color monitors, whether having cathode ray tube or liquid crystal (LCD) displays, is provided by a photometric array of photodetector and optical filter pairs. The filters include long-pass, edge filters which cover overlapping regions at the upper end of the visible spectrum and a filter which covers the entire visible spectrum. The outputs of the photodetectors are digitally synthesized to provide a response which mimics the response established by the Commission Internationale de 1′Eclairage (CIE) xyz (bar) functions almost perfectly. The response which is mimicked may be represented by the CIE color matching functions. The pairs and the associated components are mounted on a printed circuit board captured in a clamshell housing and having an array of apertures which define angularly constrained fields of view of a surface from which the light, to be colormetrically analyzed, emanates.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: November 9, 2004
    Assignee: Colorvision Administrative AG
    Inventors: David Slocum, Justin R. Louise, Cormic K. Merle, John A. Boles, Jay M. Eastman, William J. Fox, Roger J. Greenwald, Robert J. Hutchinson
  • Publication number: 20020154399
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. With the tissue specimen in the enclosed cavity of the cassette, the edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen.
    Type: Application
    Filed: June 4, 2002
    Publication date: October 24, 2002
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Patent number: 6411434
    Abstract: A cassette for retaining a specimen of surgically exposed tissue from a patient in an orientation that facilitates optical sectioning of the tissue by a confocal microscopic or other optical imaging microscope. The cassette includes a base member having a rigid optically transparent window upon which a tissue specimen is situated, a pliable membrane locatable over a substantial portion of the base member including the window, and an upper member, having an aperture therethrough, which can cover the base member to provide an enclosed cavity between the membrane and the window sealing the tissue specimen therein. With the tissue specimen in the enclosed cavity of the cassette, the edges of the tissue specimen may be positioned planar against the window and retained in that position by bonds formed between the membrane and window at multiple points or locations around the tissue specimen.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: June 25, 2002
    Assignee: Lucid, Inc.
    Inventors: Jay M. Eastman, William J. Fox, Roger J. Greenwald, Kevin P. Roesser, James M. Zavislan
  • Patent number: 6263233
    Abstract: A handheld imaging microscope for imaging tissue samples substantially beneath the surface of the tissue sample. The microscope includes an objective lens and a window defining a tissue contacting surface in pressure contacting relationship with the surface of the tissue sample when the tissue sample is imaged by the objective lens to view tissue structures for pathological applications. The objective lens focuses an illumination beam through the window to the tissue sample and receives returned reflected light of the beam representative of one or more sections of the tissue sample.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: July 17, 2001
    Assignee: Lucid, Inc.
    Inventors: James M. Zavislan, Jay M. Eastman
  • Patent number: D781435
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: March 14, 2017
    Assignee: VITAL MOTION INC.
    Inventors: Jay M. Eastman, Zachary M. Eastman