Patents by Inventor Jayanta Haldar
Jayanta Haldar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220323383Abstract: The present disclosure describes compounds of the general Formula (I) or its stereoisomers, pharmaceutically acceptable salts, poly morphs, sols ales, hydrates, thereof. These compounds or small molecular adjuvants in combination with antibiotics are effective against resistant bacterial infections.Type: ApplicationFiled: April 15, 2020Publication date: October 13, 2022Inventors: Jayanta HALDAR, Geetika DHANDA
-
Patent number: 10626148Abstract: Vancomycin conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complexes thereof is described in the present disclosure. Further, the present disclosure relates to pharmaceutical compositions comprising vancomycin conjugates, its stereoisomers, prodrugs, pharmaceutically 10 acceptable salts, metal coordination complex thereof with one or more other pharmaceutical compositions or an antibiotic. The present disclosure also describes a process of preparing said conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complex thereof, and pharmaceutical compositions as described above. Furthermore, the present disclosure describes 15 compositions and methods of treating conditions and diseases that are mediated by bacteria.Type: GrantFiled: February 5, 2016Date of Patent: April 21, 2020Inventors: Jayanta Haldar, Venkateswarlu Yarlagadda
-
Publication number: 20200030368Abstract: The present disclosure relates to a polymer network comprising a compound of Formula I cross-linked to a compound selected from the group consisting of a compound of Formula II; hyaluronate aldehyde, alginate aldehyde, dextran aldehyde, starch aldehyde, and chitosan aldehyde. It also relates to a process of preparing the polymer network. The present disclosure further relates to compositions comprising the polymer network and methods of preventing conditions and diseases that are caused by micro-organism. The present disclosure still further relates to a biocompatible antimicrobial hydrogel, a process for preparing the hydrogel, and methods of using the same, including a variety of tissue-related applications in which rapid adhesion to the tissue and gel formation is desired, as well as local delivery of pharmaceutical drugs to a site of application.Type: ApplicationFiled: July 28, 2017Publication date: January 30, 2020Inventors: Jayanta HALDAR, Jiaul HOQUE
-
Patent number: 10081655Abstract: The present invention relates to compounds that are cationic vancomycin analogs and their compositions. Method of making the compounds and their use as medicament for the treatment of bacterial infection are also disclosed.Type: GrantFiled: November 13, 2012Date of Patent: September 25, 2018Assignee: JAWAHARLAL NEHRU CENTRE FOR ADVANCEDInventors: Jayanta Haldar, Yarlagadda Venkateswarlu, Padma Akkapeddi
-
Publication number: 20180201694Abstract: The present disclosure relates to chitin derivatives of Formula (I), its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure further relates to a process of preparing the chitin derivatives, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The compounds of the present disclosure are useful in antimicrobial coatings. The present disclosure further relates to an antibacterial polymeric nanocomposite and a process for preparing the antibacterial polymeric nanocomposites.Type: ApplicationFiled: December 16, 2014Publication date: July 19, 2018Inventors: Jayanta Haldar, Jiaul Hoque, Goutham Belagula Manjunath, Padma Akkapeddi
-
Publication number: 20180009848Abstract: Vancomycin conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complexes thereof is described in the present disclosure. Further, the present disclosure relates to pharmaceutical compositions comprising vancomycin conjugates, its stereoisomers, prodrugs, pharmaceutically 10 acceptable salts, metal coordination complex thereof with one or more other pharmaceutical compositions or an antibiotic. The present disclosure also describes a process of preparing said conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complex thereof, and pharmaceutical compositions as described above.Type: ApplicationFiled: February 5, 2016Publication date: January 11, 2018Inventors: Jayanta HALDAR, Venkateswarlu YARLAGADDA
-
Publication number: 20170342110Abstract: The present disclosure provides a compound of Formula I or its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of vancomycin-sugar conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by microbes.Type: ApplicationFiled: December 24, 2015Publication date: November 30, 2017Inventors: Jayanta HALDAR, Venkateswarlu YARLAGADDA
-
Patent number: 9783490Abstract: The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.Type: GrantFiled: December 18, 2013Date of Patent: October 10, 2017Assignees: The Secretary of State for Health, Jawaharlal Nehru Centre for Advanced Scientific ResearchInventors: Jayanta Haldar, Chandradhish Ghosh, Goutham Belagula Manjunath, Padma Akkapeddi
-
Publication number: 20170144969Abstract: The present disclosure relates to polyamine conjugates, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of polyamine conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by microbes.Type: ApplicationFiled: March 13, 2015Publication date: May 25, 2017Applicants: The Secretary of State for Health, Jawaharlal Nehru Centre for Advanced Scientific ResearchInventors: Miles Carroll, Jayanta Haldar, Mohini Mohan Konai
-
Patent number: 9636356Abstract: The present disclosure relates to the development of antibacterial compounds and their nanoparticle compositions. Methods of making the compounds and their nanoparticle compositions, their use as medicament for the treatment of bacterial infection and also for suppressing potentially harmful inflammation are disclosed.Type: GrantFiled: July 5, 2013Date of Patent: May 2, 2017Assignee: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCHInventors: Jayanta Haldar, Divakara Siva Sathyanarayana Murthy Uppu, Padma Akkapeddi, Goutham Belagula Manjunath
-
Publication number: 20160303184Abstract: The present disclosure relates to vancomycin-sugar conjugates, its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of the vancomycin-sugar conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by bacteria.Type: ApplicationFiled: September 16, 2014Publication date: October 20, 2016Inventors: Jayanta HALDAR, Venkateswarlu YARLAGADDA, Goutham Belagula MANJUNATH, Mohini Mohan KONAI
-
Publication number: 20150329478Abstract: The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.Type: ApplicationFiled: December 18, 2013Publication date: November 19, 2015Applicant: The Secretary of State for HealthInventors: Jayanta Haldar, Chandradhish Ghosh, Goutham Belagula Manjunath, Padma Akkapeddi
-
Publication number: 20150238521Abstract: The present disclosure relates to the development of antibacterial compounds and their nanoparticle compositions. Methods of making the compounds and their nanoparticle compositions, their use as medicament for the treatment of bacterial infection and also for suppressing potentially harmful inflammation are disclosed.Type: ApplicationFiled: July 5, 2013Publication date: August 27, 2015Inventors: Jayanta Haldar, Divakara Siva Sathyanarayana Murthy Uppu, Padma Akkapeddi, Goutham Belagula Manjunath
-
Publication number: 20140308347Abstract: The present invention relates to compounds that are cationic vancomycin analogues and their compositions. Method of making the compounds and their use as medicament for the treatment of bacterial infection are also disclosed.Type: ApplicationFiled: November 13, 2012Publication date: October 16, 2014Applicant: JAWAHARLAL NEHRU CENTRE FOR ADVANCEDInventors: Jayanta Haldar, Yarlagadda Venkateswarlu, Padma Akkapeddi
-
Publication number: 20100136072Abstract: Hydrophobic polymeric coatings which can be non-covalently applied to solid surfaces such as metals, plastics, glass, polymers, textiles, and other substrates such as fabrics, gauze, bandages, tissues, and other fibers, in the same manner as paint, for example, by brushing, spraying, or dipping, to make the surfaces virucidal and bactericidal, have been developed.Type: ApplicationFiled: November 8, 2007Publication date: June 3, 2010Applicant: Massachusetts Institute of TechnologyInventors: Jayanta Haldar, Deqiang An, Luis Álvarez de Cienguegos, Jianzhu Chen, Alexander M. Klibanov
-
Publication number: 20090081249Abstract: Antimicrobial compositions containing two or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. In one embodiment, two or more antiviral agents are covalently coupled to the polymer. Suitable antiviral agents include, but are not limited to, sialic acid, zanamivir, oseltamivir, amantadine, rimantadine, and combinations thereof. The polymer is preferably a water-soluble, biocompatible polymer. Suitable polymers include, but are not limited to, poly(isobutylene-alt-maleic anhydride) (PIBMA), poly(aspartic acid), poly(l-glutamic acid), polylysine, poly(acrylic acid), plyaginic acid, chitosan, carboxymethyl cellulose, carboxymethyl dextran, polyethyleneimine, and blends and copolymers thereof. In another embodiment, the compositions contain a physical mixture of polymer containing one antiviral agent and polymer containing a second antiviral agent. The compositions can be formulated for enteral or parenteral administration.Type: ApplicationFiled: August 25, 2008Publication date: March 26, 2009Inventors: Jayanta Haldar, Luis Alvarez de Cienfuegos, Alexander M. Klibanov, Jianzhu Chen