Patents by Inventor Jayaram Tagat

Jayaram Tagat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
    Patent number: 10414775
    Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: September 17, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John P. Caldwell, Mary Ann Caplen, Jared N. Cumming, Kevin D. Dykstra, Alan Hruza, Claire Lankin, Derun Li, Hong Liu, Amy McCracken, Brian McKittrick, Ashwin Rao, Jayaram Tagat, Haiqun Tang, Brandon M. Taoka, Andreas Verras, Shawn P. Walsh, Wen-Lian Wu, Tianyuan Zhang
  • COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE
    Publication number: 20190218224
    Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
    Type: Application
    Filed: August 10, 2017
    Publication date: July 18, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John P. Caldwell, Mary Ann Caplen, Jared N. Cumming, Kevin D. Dykstra, Alan Hruza, Claire Lankin, Derun Li, Hong Liu, Amy McCracken, Brian McKittrick, Ashwin Rao, Jayaram Tagat, Haiqun Tang, Brandon M. Taoka, Andreas Verras, Shawn P. Walsh, Wen-Lian Wu, Tianyuan Zhang
  • Compositions comprising a combination of CCR5 and CXCR4 antagonists
    Publication number: 20070123538
    Abstract: A composition including a CXCR4 antagonist and a CCR5 antagonist represented by formula I or II: or an acceptable salt, solvate or ester thereof. The CXCR4 antagonist includes at least one of AMD-070, CS-3955, KRH-1120, KRH-2731, and KRH-1636.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 31, 2007
    Inventors: Lisa Dunkle, Julie Strizki, Bahige Baroudy, Jayaram Tagat
  • Compounds for inhibiting KSP Kinesin activity
    Publication number: 20060281778
    Abstract: The present invention provides compounds of Formula I (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
    Type: Application
    Filed: March 7, 2006
    Publication date: December 14, 2006
    Inventors: Jayaram Tagat, Timothy Guzi, Marc Labroli, Cory Poker, Angela Kerekes, Tao Yu, Hon-Chung Tsui, Neng-Yang Shih, Yushi Xiao, Sunil Paliwal
  • Compounds for inhibiting KSP kinesin activity
    Publication number: 20060247320
    Abstract: The present invention provides compounds of Formula I (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
    Type: Application
    Filed: March 7, 2006
    Publication date: November 2, 2006
    Inventors: Jayaram Tagat, Timothy Guzi, Marc Labroli, Cory Poker, Yushi Xiao, Angela Kerekes, Tao Yu, Sunil Paliwal, Hon-Chung Tsui, Neng-Yang Shih, Stuart McCombie, Vincent Madison, Charles Lesburg, Jose Duca