Patents by Inventor Jean-Claude Poignant
Jean-Claude Poignant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4877788Abstract: The invention relates to the compounds selected from those of formula I ##STR1## in which, R.sub.1 and R.sub.2 form together and with the piperazine-2,6-dione radical to which they are attached a hexahydropyrazinoisoquinolinedione radical, a primidinyl radical or a phenyl radical optionally substituted by an alkyl radical of 1 to 4 carbon atoms or a trifluoromethyl radical,n is an integer from 2 to 4.Type: GrantFiled: June 14, 1988Date of Patent: October 31, 1989Assignee: Adir Et CieInventors: Gilbert Lavielle, Jean Claude Poignant
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Patent number: 4711885Abstract: Triazole compounds of the formula: ##STR1## in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C.sub.1 -.sub.5 alkyl, or C.sub.1 -.sub.5 alkoxy, orX and X' together represent methylenedioxy,n is an integer of from 1 to 6,a is 0, 1 or 2;b is 0, 1, 2 or 3;c is 0, 1 or 2 andd is 2, 3, 4 or 5 such that a+b+c+d is equal to 4, 5, 6 or 7.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of pain and anxiety.Type: GrantFiled: April 1, 1986Date of Patent: December 8, 1987Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Pierre Hugon, Jean-Claude Poignant
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Patent number: 4613601Abstract: Benzodioxine compounds of the formula: ##STR1## in which Het is a five- or six-membered heterocyclic radical containing from one to three hetero atoms, and from one to three double bonds, optionally substituted by one or more alkyl or alkoxy radicals each from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines, especially in the treatment of psychoses.Type: GrantFiled: January 22, 1985Date of Patent: September 23, 1986Assignee: Adir, S.A.R.L.Inventors: Gilbert Regnier, Jean-Claude Poignant
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Patent number: 4567181Abstract: Compounds of the formula: ##STR1## in which: R.sub.1 and R.sub.2 each represent, independently of one another, hydrogen, halogen, alkyl or alkoxy having from 1 to 4 carbon atoms, sulphonamide possibly substituted by an alkyl radical having from 1 to 4 carbon atoms; or together methylenedioxy, n is 0 or 1,in racemic form or in the form of optical isomers, and also their salts of addition with pharmaceutically acceptable acids. Useful in the treatment of ailments and/or conditions which are adrenoreceptor-related, such relationship being well known in the art.Type: GrantFiled: April 5, 1984Date of Patent: January 28, 1986Assignee: ADIR, s.a.r.l.Inventors: Charles Malen, Jean-Louis Peglion, Michel Laubie, Jean-Claude Poignant
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Patent number: 4496557Abstract: Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.Type: GrantFiled: August 16, 1982Date of Patent: January 29, 1985Assignee: AdirInventors: Charles Malen, Jean-Claude Poignant
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Patent number: 4459306Abstract: This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.Type: GrantFiled: April 6, 1981Date of Patent: July 10, 1984Assignee: Science Union et CieInventors: Charles Malen, Jean-Claude Poignant
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Patent number: 4267178Abstract: Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2,m is 0 or 1, andHet is pyridyl, pyrimidinyl, pyrazinyl, thiazolyl or thiadiazolyl each optionally substituted by one or more alkyl having from 1 to 5 carbon atoms inclusive.These compounds and their physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of hypertension.Type: GrantFiled: February 26, 1979Date of Patent: May 12, 1981Assignee: Science Union et Cie, Societe Francaise de Recherche Med.Inventors: Gilbert Regnier, Michel Laubie, Jean-Claude Poignant
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Patent number: 4260610Abstract: Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2,X is oxygen and Y is sulfur or sulfonyl or X and Y are both sulfur or sulfonyl, andHet is a 5- or 6-membered heterocyclic radical having from 1 to 3 hetero atoms inclusive selected from nitrogen and sulfur and optionally substituted by one or more alkyl each having from 1 to 5 carbon atoms inclusive.These compounds may be used as medicines, especially in the treatment of central nervous system disorders and Parkinson's disease.Type: GrantFiled: November 3, 1978Date of Patent: April 7, 1981Assignee: Science Union Et CieInventors: Gilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignant
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Patent number: 4177272Abstract: Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl,X is nitrogen and simultaneously Y is oxygen or sulfur, orX is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, andR is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl.These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.Type: GrantFiled: December 27, 1977Date of Patent: December 4, 1979Assignee: Science Union et CieInventors: Gilbert Regnier, Roger Canevari, Michel Laubie, Jean-Claude Poignant
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Patent number: 4154851Abstract: This invention relates to novel .omega.-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers.They are produced by condensing an oxoalkanoic acid with a benzylamine under reducing conditions.This invention also relates to .omega.-benzylamino alkanoic amides and to .omega.-benzylamino alkanoic acid esters.They have therapeutical use, namely in the psychotherapeutical field. They are utilized in the form of pharmaceutical compositions.Type: GrantFiled: March 11, 1977Date of Patent: May 15, 1979Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant
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Patent number: 4123531Abstract: This invention relates to novel acetamides, the nitrogen of which is substituted with an amino lower alkyl chain.This invention also relates to a process for producing the said N-substituted acetamides.The end compounds have therapeutical utility and find a use as anti-convulsant agents.Type: GrantFiled: November 26, 1976Date of Patent: October 31, 1978Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Michel Laubie, Jean-Claude Poignant
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Patent number: 4112092Abstract: Naphthyl derivatives of the formula: ##STR1## wherein: R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, andR.sub.2 and R.sub.3, which are the same or different, are hydrogen, lower alkyl or phenyl,Or R.sub.2 and R.sub.3 joined together are --CH .dbd. CH -- CH .dbd. CH--.These compounds are used as medicines, especially in the treatment of disorders of central nervous system (CNS), Parkinson's disease and cardiovascular disorders.Type: GrantFiled: April 8, 1977Date of Patent: September 5, 1978Assignee: Science Union et CieInventors: Gilbert Regnier, Roger Canevari, Jean-Claude Poignant
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Patent number: 4102890Abstract: Cyclopropylmethylamines which are substituted on the 2-position of nitrogen heterocycles so as to provide new compounds of the formula ##STR1## wherein A is oxygen, sulfur, or nitrogen; the other "R" variables in general are hydrogen, lower-alkyl, cyclopropyl, or lower-alkyl substituted cyclopropyl; and the n's are the numbers 0 to 3, inclusive, and acid addition salts thereof, are disclosed. The compounds are cardiovascular agents, which are depressive of the central nervous system. Their effects include hypnosis, analgesia, and neuro-modulation. They can be used as anti-hypertensive agents.Type: GrantFiled: August 11, 1976Date of Patent: July 25, 1978Assignee: Science-Union et Cie, Societe Francaise de Recherche MedicaleInventors: Charles Malen, Monique Desnos, Michel Laubie, Jean-Claude Poignant
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Patent number: 4100286Abstract: Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C.sub.2 to C.sub.6 inclusive, X is chlorine, hydroxy, alkoxy or alkylthio each from C.sub.1 to C.sub.5 inclusive, R is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.3 inclusive, R' is halogen, alkyl or alkoxy each from C.sub.1 to C.sub.3 inclusive and n is 0, 1 or 2.These compounds, their optical isomers and their physiologically tolerable salts are used as medicines especially in the treatment of central nervous system disorders.Type: GrantFiled: November 15, 1976Date of Patent: July 11, 1978Assignee: Science Union et CieInventors: Gilbert Regnier, Roger Canevari, Jean-Claude Poignant, Michel Laubie
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Patent number: 4092423Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.Type: GrantFiled: September 16, 1976Date of Patent: May 30, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
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Patent number: 4086355Abstract: The invention relates to novel spirodecane derivatives and more specifically to novel azaspirodecane diones.The invention also provides process for producing said azaspirodecane diones which consists mainly in cyclizing a disubstituted glutaronitrile or a glutaric acid in the presence of an amino compound.The compounds of the present invention have interesting pharmacological properties and they find therapeutical uses.Type: GrantFiled: January 19, 1976Date of Patent: April 25, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Michel Vincent, Georges Remond, Jean-Claude Poignant
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Patent number: 4070485Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.Type: GrantFiled: September 16, 1976Date of Patent: January 24, 1978Assignee: Science Union et CieInventors: Charles Malen, Pierre Roger, Jean-Claude Poignant, Xavier Pascaud
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Patent number: 4066662Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: December 30, 1976Date of Patent: January 3, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4048313Abstract: This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.Type: GrantFiled: January 9, 1975Date of Patent: September 13, 1977Assignee: Science Union et CieInventors: Michel Vincent, Georges Remond, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4048321Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: September 13, 1977Assignee: Science Union et CieInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant