Abstract: Methods, systems and computer readable media for proof of election on a blockchain are provided. According to an aspect, the methods, systems and computer readable media include: a) publishing a block on a blockchain network, said block including at least one criterion for selecting an elected actor based on a unique election candidacy; b) receiving election confirmations messages from one or more actors, said election confirmation messages including the unique election candidacy and one or more transactions selected by said one or more actors; c) applying the at least one criterion to validate elected actors based on the unique election candidacy; and d) publishing a subsequent block on the blockchain network, said subsequent block including the one or more transactions in the election confirmation messages received from the elected actors.

Abstract: An apparatus and method are provided for inhibiting instruction manipulation. The apparatus has execution circuitry for performing data processing operations in response to a sequence of instructions from an instruction set, and decoder circuitry for decoding each instruction in the sequence in order to generate control signals for the execution circuitry. Each instruction comprises a plurality of instruction bits, and the decoder circuitry is arranged to perform a decode operation on each instruction to determine from the value of each instruction bit, and knowledge of the instruction set, the control signals to be issued to the execution circuitry in response to that instruction. An input path to the decoder circuitry comprises a set of wires over which the instruction bits of each instruction are provided.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: The invention relates to oral care compositions comprising a first stannous ion source, a second stannous ion source, wherein the second stannous ion comprises stannous pyrophosphate, and a source of zinc selected from zinc oxide, zinc citrate, zinc lactate, and combinations thereof, and a humectant system comprising glycerin and sorbitol, and a thickening system, as well as to methods of using and making these compositions.

Abstract: A fluid dispenser comprising a body (1), a fluid reservoir (2), a dispenser member, such as a pump or a valve, mounted on said reservoir (2), and a dose indicator device for indicating the number of doses of fluid that have been dispensed or that remain to be dispensed from said reservoir, the dispenser being characterized in that said dose indicator device includes a first safety system for actuating the dose indicator device once the dispenser has performed a predetermined incomplete actuation stroke, even if the dispenser does not perform the complete actuation stroke.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-?-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

Abstract: A method for de-icing or anti-icing an aircraft portion having at least one piezoelectric element fastened on the inner face of the aircraft portion includes, during a design phase of the aircraft portion, placing the piezoelectric element on an area of the aircraft portion to determine frequencies of resonance and increased dynamic coupling, and during the de-icing or anti-icing of the aircraft portion, the same piezoelectric element is excited according to the natural frequencies of the area.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: Data processing circuitry comprises a set of two or more computational units to perform respective computational operations; an instruction decoder to decode successive data processing instructions and, for a given data processing instruction, to control one or more of the computational units to perform those computational operations required to execute the given data processing instruction; and control circuitry responsive to the given data processing instruction, to control one or more others of the computational units to perform further computational operations, other than the computational operations required to execute the given data processing instruction, during execution of the given data processing instruction.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: A spectroscopy device including: an electron source arranged to emit a flux of electrons towards a sample, a pulsed photon source emitting photon pulses towards the sample, at least one spectrometer for receiving a flux of electrons originating from the sample, at least one electron detector; and at least one deflector, between the electron source and the at least one electron detector, synchronized with the pulsed photon source to allow or prevent the passage of electrons emitted by the electron source, towards the electron detector.

Abstract: An apparatus and method are provided for controlling use of a register cache. The apparatus has execution circuitry for executing instructions to process data values, and a register file comprising a plurality of registers in which to store the data values for access by the execution circuitry. A register cache is also provided that has a plurality of entries and is arranged to cache a subset of the data values for access by the execution circuitry. Each entry is arranged to cache a data value and an indication of the register associated with that cached data value. Prefetch circuitry then performs prefetch operations to prefetch data values from the register file into the register cache. Timing indication storage is used to store, for each data value to be generated as a result of instructions being executed within the execution circuitry, a register identifier for that data value, and timing information indicating when that data value will be generated by the execution circuitry.