Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: An apparatus and method are provided for controlling use of a register cache. The apparatus has decode circuitry for decoding instructions retrieved from memory, execution circuitry to execute the decoded instructions in order to perform operations on data values, and a register file having a plurality of registers for storing the data values to be operated on by the execution circuitry. Further, a register cache is provided that comprises a plurality of entries, and is arranged to cache a subset of the data values. Each entry is arranged to cache a data value and an indication of the register associated with that cached data value. Prefetch circuitry is then used to prefetch data values from the register file into the register cache. Further, operand analysis circuitry derives source operand information for an instruction fetched from memory, at least prior to the decode circuitry completing decoding of that instruction.

Abstract: A protective and abradable coating composition is suitable for application on rolls and more particularly for application on conveyor rolls. The abradable coating is suitable for use in high temperature applications. Rolls incorporating the coating may be produced and used according to disclosed processes and procedures. Application of the composition to rolls reduces corrosion by aluminium melt, and enables the removal of built-up substances by friction. The life time of the roll is thereby increased.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: A fluid dispenser comprising a body (1), a fluid reservoir (2), a dispenser member, such as a pump or a valve, mounted on said reservoir (2), and a dose indicator device for indicating the number of doses of fluid that have been dispensed or that remain to be dispensed from said reservoir, the dispenser being characterized in that said dose indicator device includes a first safety system for actuating the dose indicator device once the dispenser has performed a predetermined incomplete actuation stroke, even if the dispenser does not perform the complete actuation stroke.

Abstract: An apparatus comprises a set of registers and mapping circuitry to perform a mapping operation to map each of a set of register specifiers to a respective register from among the set of registers in dependence on a mapping function. The mapping function is dependent on a key value. In addition, the mapping for at least two register specifiers from among the set of register specifiers is dependent on the same key value.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: A data processing apparatus comprises register rename circuitry for mapping architectural register specifiers specified by instructions to physical registers to be accessed in response to the instructions. Available register control circuitry controls which physical registers are available for mapping to an architectural register specifier by the register rename circuitry. For at least one group of two or more physical registers, the available register control circuitry controls availability of the registers based on a group tracking indication indicative of whether there is at least one pending access to any of the physical registers in the group.

Abstract: An apparatus has processing circuitry to perform data processing in one of two or more operating states associated with different levels of privilege. At least one operating state holding element holds a state indication indicating a current operating state of the processing circuitry. In response to a transition of a reset signal from a first value to a second value for triggering a reset of the processing circuitry, the at least one operating state holding element resets the state indication to indicate a default operating state other than a most privileged operating state of the two or more operating states.

Abstract: The invention relates to a method for assembling a first and a second part of a lighting device for a vehicle by mirror welding, including a step of supplying the parts wherein each part comprises, in the interface area thereof for contact with the other part, a weld bead intended to come into contact against the weld bead of the other part during the mirror welding, the weld bead of at least one of the parts is provided with a plurality of expander ribs (N) spread out along the weld bead, in such a way as to locally expand the width of the weld bead.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: An apparatus has a number of data holding elements for holding data values which are reset to a reset value in response to a transition of a signal at a reset signal input of the data holding element from a first value to a second value. A reset tree is provided to distribute a reset signal received at root node of the reset tree to the reset signal inputs of the data holding elements. At least one reset attack detection element is provided, with its reset signal input coupled to a given node of the reset tree, to assert an error signal when its reset signal input transitions from the first value to a second value. Reset error clearing circuitry triggers clearing of the error signal, when the reset signal at the root node of the reset tree transitions from the second value to the first value.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.

Abstract: This invention relates to oxime and alkoxy derivatives of the general formula (I), or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.

Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.

Abstract: Data processing circuitry comprises a set of two or more computational units to perform respective computational operations; an instruction decoder to decode successive data processing instructions and, for a given data processing instruction, to control one or more of the computational units to perform those computational operations required to execute the given data processing instruction; and control circuitry responsive to the given data processing instruction, to control one or more others of the computational units to perform further computational operations, other than the computational operations required to execute the given data processing instruction, during execution of the given data processing instruction.