Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.

Abstract: An apparatus has register rename circuitry to map architectural register specifiers specified by instructions to physical register specifiers identifying physical registers. A restoration table identifies at least one restoration mapping between an architectural register specifier and a previously mapped physical register specifier. Register reserving circuitry indicates one or more reserved register specifiers. In response to detecting that a speculative instruction corresponding to a restoration mapping has been committed when that instruction or an older instruction still could potentially read a register, the register reserving circuitry indicates the physical register specifier of that restoration mapping as reserved.

Abstract: A document preview system provides previews of a native document to client devices. The previews include comments associated with native objects in the native document. The document preview system identifies bounding areas in the preview associated with the native objects, which may be identified by the rendering markers applied to the native document prior to rendering. Using the bounding areas, the document preview system identifies comments for the native document and determines the location to display the comment using native objects associated with the comment. When a new comment is received from a user for a preview of a native document, the document preview system determines native objects for the new comment that match a user's selection for placing the new comment. The new comment is inserted with the native objects in the native document.

Abstract: An apparatus comprising: a set of registers; and mapping circuitry to perform a mapping operation to map each of a set of register specifiers to a respective register from among the set of registers in dependence on a mapping function. The mapping function is dependent on a key value. In addition, the mapping for at least two register specifiers from among the set of register specifiers is dependent on the same key value.

Abstract: An apparatus and method are provided for controlling use of a register cache. The apparatus has decode circuitry for decoding instructions retrieved from memory, execution circuitry to execute the decoded instructions in order to perform operations on data values, and a register file having a plurality of registers for storing the data values to be operated on by the execution circuitry. Further, a register cache is provided that comprises a plurality of entries, and is arranged to cache a subset of the data values. Each entry is arranged to cache a data value and an indication of the register associated with that cached data value. Prefetch circuitry is then used to prefetch data values from the register file into the register cache. Further, operand analysis circuitry derives source operand information for an instruction fetched from memory, at least prior to the decode circuitry completing decoding of that instruction.

Abstract: An apparatus and method are provided for controlling use of a register cache. The apparatus has execution circuitry for executing instructions to process data values, and a register file comprising a plurality of registers in which to store the data values for access by the execution circuitry. A register cache is also provided that has a plurality of entries and is arranged to cache a subset of the data values for access by the execution circuitry. Each entry is arranged to cache a data value and an indication of the register associated with that cached data value. Prefetch circuitry then performs prefetch operations to prefetch data values from the register file into the register cache. Timing indication storage is used to store, for each data value to be generated as a result of instructions being executed within the execution circuitry, a register identifier for that data value, and timing information indicating when that data value will be generated by the execution circuitry.

Abstract: Example aspects of the present disclosure allow an end user to determine how a finite amount of a measurable resource is allocated among the various balanceable and feature zones of control defined within the overall measurable resource control system, and which can be implemented using a wide variety of hardware/components. A control program allows the end user unprecedented flexibility and control to determine how the resource is allocated among the various zones or types of resource use within the application, as long as the total resource consumed does not exceed the predetermined/predefined total maximum allowable resource. When the end user adjusts a feature or balanceable zone level, the control program adjusts the other balanceable zones based on predefined algorithms, when necessary, to ensure that the maximum measurable resource consumed by the system does not exceed the predetermined/predefined overall maximum resource allocation.

Abstract: An apparatus has processing circuitry to perform data processing in one of two or more operating states associated with different levels of privilege. At least one operating state holding element holds a state indication indicating a current operating state of the processing circuitry. In response to a transition of a reset signal from a first value to a second value for triggering a reset of the processing circuitry, the at least one operating state holding element resets the state indication to indicate a default operating state other than a most privileged operating state of the two or more operating states.

Abstract: An apparatus has a number of data holding elements for holding data values which are reset to a reset value in response to a transition of a signal at a reset signal input of the data holding element from a first value to a second value. A reset tree is provided to distribute a reset signal received at root node of the reset tree to the reset signal inputs of the data holding elements. At least one reset attack detection element is provided, with its reset signal input coupled to a given node of the reset tree, to assert an error signal when its reset signal input transitions from the first value to a second value. Reset error clearing circuitry triggers clearing of the error signal, when the reset signal at the root node of the reset tree transitions from the second value to the first value.

Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.

Abstract: The invention relates to a device (30) for the extraction and the transfer of granular mineral materials at high temperature contained in a first enclosure including a fixed upper part (32) and a mobile lower part (34) delimiting a duct (36), the mobile lower part (34) being movable in a determined direction (50) between a advanced position and a retracted position, and vice versa, to allow the flow of the granular mineral materials in the duct (36). The device further includes means (78, 80) for moving and guiding the mobile part (34) relative to the fixed part (32). The fixed part (32) and the mobile part (34) each comprise a metal outer shell (38, 58), and an inner shell (40; 60) made by stacking at least a first coating (42; 62) of thermally insulating material mounted on the metal outer shell (38; 58), and a second coating (44; 64) of refractory material mounted on the first coating (42, 62).

Abstract: This invention relates to a derivative of the general formula (I), as follows: or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof for use as a medicament for the treatment and/or prevention of muscle atrophy in mammals and/or for limiting muscular atrophy in mammals and/or to promote muscle growth in exercising mammals aimed at increasing muscle mass and quality, preventing the occurrence of symptoms of sarcopenia related to age or rehabilitation after a muscle loss, age-related muscle atrophy and/or the consequences of drug therapy and/or immobilization and/or cachexia.

Abstract: The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.

Abstract: A refractory article used at high temperature contains a silica, calcium silicate or mullite matrix with at least a surface having an open porosity filled at least partially with a sulfate, phosphate, or carbonate salt or a mixture of sulfate, phosphate or carbonate salts. The refractory article is resistant to the corrosion and build-up of non-ferrous metals and their alloys.

Abstract: A data processing system 2 includes multiple out-of-order issue queues 8, 10. A master serialization instruction MSI received by a first issue queue 8 is detected by slave generation circuitry 24 which generates a slave serialization instruction SSI added to a second issue queue 10. The master serialization instruction MSI manages serialization relative to the instructions within the first issue queue 8. The slave serialization instruction SSI manages serialization relative to the instructions within the second issue queue 10. The master serialization instruction MSI and the slave serialization instruction SSI are removed when both have met their serialization conditions and are respectively the oldest instructions within their issue queues.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.