Patents by Inventor Jean-Louis Mandel

Jean-Louis Mandel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BBS10 related diagnostic methods for Bardet-Biedl syndrome
    Patent number: 8163482
    Abstract: The present invention relates to the identification of a gene, designated BBS1O, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS, also are described.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: April 24, 2012
    Inventors: Nicholas Katsanis, Helene Dollfus, Corinne Stoetzel, Erica E. Davis, Philip L. Beales, Jean-Louis Mandel, Richard Alan Lewis
  • BBS10 RELATED DIAGNOSTIC METHODS AND REAGENTS FOR BARDET-BIEDL SYNDROME
    Publication number: 20100130429
    Abstract: The present invention relates to the identification of a gene, designated BBS1O, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS, also are described.
    Type: Application
    Filed: February 23, 2007
    Publication date: May 27, 2010
    Inventors: Nicholas Katsanis, Helene Dollfus, Corinne Stoetzel, Erica E. Davis, Philip Beals, Jean-Louis Mandel, Richard Alan Lewis
  • Tyrosine-phosphatase-related protein
    Patent number: 6312688
    Abstract: The present invention relates to a tyrosine-phosphatase-related protein, a DNA which codes for such a protein and a process for producing such a protein. In addition, the invention concerns the use of the DNA and protein and antibodies directed against the protein.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: November 6, 2001
    Assignees: Deutsches Krebsotorschungszentrum Stiftung des Offentlichen Rechts,, Institut National de la Sante et de la Recherche Medicale
    Inventors: Annemarie Poustka, Petra Kioschis, Jocelyn Laporte, Ling Jia Hu, Jean Louis Mandel, Niklas Dahl
  • Monoclonal and polyclonal antibodies relating to fragile X syndrome
    Patent number: 6242576
    Abstract: The DNA sequence spanning the fragile X site on the X human chromosome has been obtained in purified and isolated form. As fragile X is associated with mental retardation, the availability of a DNA which spans this locus permits diagnosis and treatment of the related mental disorders. Polyclonal and monoclonal antibodies to an amino acid sequence encoded by SEQ ID NO:1, a DNA sequence from the Fragile X site, are also disclosed.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 5, 2001
    Assignees: Women's and Children's Hospital, Washington University
    Inventors: Grant R. Sutherland, Robert I. Richards, David Schlessinger, Ramaiah Nagaraja, Eric J. Kremer, Sui Yu, Elizabeth Baker, John C. Mulley, Jean-Louis Mandel, Melanie April Pritchard, Michael Lynch
  • DNA sequences related to fragile X syndrome
    Patent number: 6197500
    Abstract: The DNA sequence spanning the fragile X site on the X human chromosome has been obtained in purified and isolated form. As fragile X is associated with mental retardation, the availability of a DNA which spans this locus permits diagnosis and treatment of the related mental disorders.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: March 6, 2001
    Assignee: Adelaide Medical Centre for Women and Children
    Inventors: Grant R. Sutherland, Robert I. Richards, David Schlessinger, Ramaiah Nagaraja, Eric J. Kremer, Sui Yu, Elizabeth Baker, John C. Mulley, Jean-Louis Mandel, Melanie April Pritchard, Michael Lynch
  • X-linked adrenoleukodystrophy gene and corresponding protein
    Patent number: 6013769
    Abstract: The present invention relates to adrenoleukodystrophy proteins and uses thereof. More particularly, the invention relates to human adrenoleukodystrophy proteins. Mutations of the adrenoleukodystrophy protein cause adrenoleukodystrophy or adrenomyelopathy.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: January 11, 2000
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Jean-Louis Mandel, Patrick Aubourg, Jean Mosser, Claude Sarde
  • X-linked adrenoleukodystrophy gene and corresponding protein
    Patent number: 5869039
    Abstract: A method for the treatment of adrenoleukodystrophy or adrenomyeloneuropathy, in which there is administered to a human patient in need of the same an effective amount of hematopoietic cells modified ex vivo by infection with a retroviral vector containing a nucleic acid fragment comprising a sequence as represented on FIG. 2 (SEQ. ID No: 1) or FIG. 6 (SEQ. ID. No: 4-17) or FIG. 7 (SEQ. ID No: 18-23). Also, human hematopoietic cells can be treated ex vivo to correct the content of very long chain fatty acids in them, by providing human hematopoietic cells of a patient affected by adrenoleukodystrophy or adrenomyeloneuropathy, and infecting them ex vivo with a retroviral vector containing, operably linked to a promoter, a nucleic acid fragment as above. The expression of the nucleic acid in the hematopoietic cells corrects the content of very long chain fatty acids in the hematopoietic cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 9, 1999
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Jean-Louis Mandel, Patrick Aubourg, Jean Mosser, Claude Sarde
  • X-linked adrenoleukodystrophy gene and corresponding protein
    Patent number: 5644045
    Abstract: The cDNA and genomic DNA sequences encoding the human adrenoleukodystrophy protein are provided. Mutations of the adrenoleukodystrophy protein cause adrenoleukodystrophy or adrenomyelopathy.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: July 1, 1997
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Jean-Louis Mandel, Patrick Aubourg, Jean Mosser, Claude Sarde