Patents by Inventor Jean-Luc Bonnet

Jean-Luc Bonnet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10420941
    Abstract: An implantable device includes a lead, for example for neurostimulation of the vagus nerve. The lead includes a series of stimulation electrodes and a series of external electrodes for bioimpedance measurements on blood flow located in the same region, for example on the carotid artery. The device further includes means for separating into frequency bands the measured bioimpedance signal, the bands selected to reflect different respective activities such as vasomotor activity, hemodynamic activity, respiration, and cardiac rhythm activity.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 24, 2019
    Assignee: Sorin CRM SAS
    Inventors: Jean-Luc Bonnet, Thierry Legay, Dominique Decoene, Patrick Le Gousse, Mathieu Collignon
  • Publication number: 20190247663
    Abstract: An active implantable medical device includes a VNS pulse bursts generator for stimulation of the vagus nerve according to several selectable configurations. The device may further include a sensor of the current activity level of the patient. The generator is controlled on the activity signal via a classifier determining the class of the current level of activity among a plurality of classes of activity. A controller selects a configuration of VNS therapy depending on the class of activity thus determined. Limits of the activity classes are dynamically changeable by a calibration module that conducts a historical analysis of the successive current activity levels over a predetermined analysis period. The calibration module can prepare a histogram of the historical analysis, and can define the limits of the activity classes depending on the outcome of the historical analysis and the histogram.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Applicant: SORIN CRM SAS
    Inventor: Jean-Luc Bonnet
  • Patent number: 10300280
    Abstract: An active implantable medical device includes a VNS pulse bursts generator for stimulation of the vagus nerve according to several selectable configurations. The device may further include a sensor of the current activity level of the patient. The generator is controlled on the activity signal via a classifier determining the of class the current level of activity among a plurality of classes of activity. A controller selects a configuration of VNS therapy depending on the class of activity thus determined. Limits of the activity classes are dynamically changeable by a calibration module that conducts a historical analysis of the successive current activity levels over a predetermined analysis period. The calibration module can prepare a histogram of the historical analysis, and can define the limits of the activity classes depending on the outcome of the historical analysis and the histogram.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 28, 2019
    Assignee: Sorin CRM SAS
    Inventor: Jean-Luc Bonnet
  • Publication number: 20190151666
    Abstract: An energy harvester converts into electrical energy the external stresses applied to the implant at the heartbeat rhythm. This harvester includes an inertial unit and a transducer delivering an oscillating electrical signal that is rectified and regulated for powering the implant and charging an energy storage component. The instantaneous variations of this electrical signal are analyzed in a detection window following or preceding a ventricular contraction, to obtain atrial activity information representative of the atrium contribution to the electric signal, in particular information about the presence/absence of a spontaneous atrial contraction, and/or parameters making it possible to determine an atrioventricular delay to be applied if the ventricle has to be stimulated.
    Type: Application
    Filed: November 22, 2018
    Publication date: May 23, 2019
    Inventor: Jean-Luc Bonnet
  • Publication number: 20190126048
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 2, 2019
    Applicants: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Publication number: 20190091479
    Abstract: An energy harvester converts into electrical energy the external stresses applied to the implant at the heartbeat rhythm. This harvester comprises an inertial unit and a transducer delivering an electrical signal that is rectified and regulated for powering the implant and charging an energy storage component. The charge level of the energy storage component is compared with a lower threshold to detect an insufficient charge, and a dynamic charging control circuit modifies, as and whenever necessary, and if the current patient's state allows it, a stimulation parameter in a direction liable to increase in return the mean level of the mechanical energy that is produced and harvested.
    Type: Application
    Filed: September 24, 2018
    Publication date: March 28, 2019
    Inventor: Jean-Luc BONNET
  • Patent number: 10166393
    Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: January 1, 2019
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1
    Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
  • Patent number: 10159840
    Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 25, 2018
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM-INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
  • Publication number: 20180353760
    Abstract: This disclosure relates to an active medical device which includes a generator for producing multiphase nerve stimulation pulse trains, each pulse train including at least one stimulation pulse preceded by a precharge pulse and ending with a passive discharge pulse. The active medical device also includes a sensor configured to output a control signal representative of a physiological and/or physical parameter capable of being influenced by the output of nerve stimulation pulse trains. The active medical device also includes an automatic charge compensation control circuit configured to receive at the input the control signal output by the sensor, determine an amplitude and/or a precharge pulse time as a function of at least one predetermined criterion, and output to the generator a precharge pulse control signal to be produced at the output.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 13, 2018
    Inventors: Jean-Luc Bonnet, Laure Duchemin Laporte, Arnaud Follenius
  • Patent number: 10124173
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 13, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM- INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 10099056
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: October 16, 2018
    Assignees: Sorin CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 10092756
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: October 9, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Publication number: 20180271452
    Abstract: The invention relates to an active implantable medical device comprising a processing unit able to be alternately operated during a predetermined period of activity and on standby during a standby period in a cyclical manner, and means for acquiring data relating to physiological and/or physical activity. The device also comprises means for calculating a frequency analysis of the data acquired, said calculating means being capable of successively perform part of the frequency analysis during periods of activity of the processing unit.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 27, 2018
    Inventors: Jean-Luc Bonnet, Thomas Herrmann, Christine Henry, Alfredo Hernandez, Guy Carrault
  • Patent number: 9981132
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: May 29, 2018
    Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALE
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
  • Patent number: 9782117
    Abstract: A system for assessing a sympathovagal balance of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and outputs a stimulation energy, a sensor configured to measure a physiological signal, and a processor. The processor is configured to control the generator during a plurality of sequences to produce the stimulation pulses over a test period, determine a biological parameter of a current activity of the patient derived from the physiological signal, determine a variation of the biological parameter resulting from the stimulation pulses, and determine a sympathovagal balance index according to the variation in the biological parameter.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: October 10, 2017
    Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1
    Inventors: Jean-Luc Bonnet, Alfredo Hernandez
  • Patent number: 9770594
    Abstract: A medical device includes a VNS pulse burst generator for stimulation of the vagus nerve, and a controller for analyzing the cardiac rhythm. It further includes a sequencer that uses an estimator to calculate during a given cycle an estimate of the temporal position of the R wave of the next cycle. The controller is configured to define the moment of application of the VNS pulse burst as an instant corresponding to the estimate minus a predetermined advance delay. VNS therapy is thus delivered in a non-vulnerable period, near the end of the period of natural ventricular escape.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: September 26, 2017
    Assignee: SORIN CRM SAS
    Inventors: Jean-Luc Bonnet, Christine Henry
  • Publication number: 20160375251
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
  • Publication number: 20160375252
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
  • Publication number: 20160375249
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE
  • Publication number: 20160375250
    Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Inventors: Jean-Luc BONNET, Alfredo HERNANDEZ, Guy CARRAULT, Hector ROMERO, Virginie LE ROLLE