Abstract: Embodiments of an improved photodynamic therapy device are provided. An example of the device includes an irradiation head having a first end and a surface at a second end, the surface having a radius of curvature. The device also includes a plurality of light sources disposed on the curved surface. The plurality of light sources are configured to emit light having at least one wavelength corresponding approximately to an excitation peak of at least one photosensitizer. The light emitted by the plurality of light sources is focused to a focal point based on the radius of curvature of the surface and a target surface (e.g., a corneal surface of an eye) may be positioned at the focal point for treatment.

Abstract: Systems and methods for an improved dosimeter for measuring dosage for photodynamic therapy treatment are provided. An example systems includes a dosimeter comprising a variable optical filter system configured to receive a second light, the second light comprising luminescence produced by singlet oxygen and one or more background signal and selectively transmit the luminescence and the one or more background signals as a third light, the variable optical filter system comprises a plurality of optical bandpass filters that are switchable to selectively transmit the luminescence and the one or more background signals. The dosimeter also includes a photoreceiver configured to receive the third light and configured to generate electrical output signals corresponding to the luminescence and the one or more background signals, the electrical output signals being indicative of an amount of the singlet oxygen produced based on activating the photosensitizer.

Abstract: Ocular photosensitivity analyzer. In an embodiment, a programmable light source, comprising a plurality of multi-spectra light modules, is configured to emit light according to a lighting condition. For one or a plurality of iterations, the programmable light source is activated to emit the light according to the lighting condition, and collect a response, by a subject, to the emitted light via a sensing system comprising one or more sensors. Between iterations, the programmable light source may be reconfigured based on the response to determine a visual photosensitivity threshold of the subject.

Abstract: A system for ophthalmic imaging comprising an ophthalmic device configured to obtain stereoscopic images of an eye of a patient and to transmit the images in real-time to a display device via a network for viewing by practitioners. The ophthalmic device comprises at least an optic assembly, a processing assembly, a slit assembly, such as a slit lamp, and a positioning assembly. Control devices structured to control the ophthalmic device over the network, such as the world wide web, can be disposed at a plurality of locations, and may be remote from the ophthalmic device while providing real time control of the parameters of the ophthalmic device by the practitioner(s) associated therewith.

Abstract: Methods and systems for retrofitting an ophthalmic device to obtain stereoscopic images of an eye of a patient and to transmit the images in real-time to a display device via a network for viewing by practitioners. The ophthalmic device may comprise at least an optic assembly, a processing assembly, a slit assembly, such as a slit lamp, and a positioning assembly. Control devices structured to control the ophthalmic device over the network, such as the world wide web, can be disposed at a plurality of locations, and may be remote from the ophthalmic device while providing real time control of the parameters of the ophthalmic device by the practitioner(s) associated therewith.

Abstract: A spectrally adjustable ocular photosensitivity analyzer (SAOPA) is capable of emulating light sources common in everyday environments. An array of multiple light sources generates the desired spectra at intensities that are sufficient to elicit an uncomfortable level of photostress or light discomfort in normal human subjects sufficient to identify, and preferably quantify, a visual photosensitivity threshold of a human subject.

Abstract: A spectrally adjustable ocular photosensitivity analyzer (SAOPA) is capable of emulating light sources common in everyday environments. An array of multiple light sources generates the desired spectra at intensities that are sufficient to elicit an uncomfortable level of photostress or light discomfort in normal human subjects sufficient to identify, and preferably quantify, a visual photosensitivity threshold of a human subject.

Abstract: A method for refilling a lens of an eye or increasing the elasticity of a lens of an eye includes removing a central portion of the lens core through the eye's cornea, a capsulorhexis in the eye's lens capsule and a gullet extending at least partially through the cortex of the lens. The lens is then refilled with a synthetic lens material. Sufficient lens core is left in place so that the synthetic material is not in contact with a lens capsule of the eye. The synthetic material used for refilling may be selected and may be formed in a shape and thickness so as to affect the refractive characteristics of the lens. An endocapsular lenticule may be inserted in the lens to affect the refractive characteristics of the lens.

Abstract: An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.

Abstract: A method for refilling a lens of an eye or increasing the elasticity of a lens of an eye includes removing a central portion of the lens core through the eye's cornea, a capsulorhexis in the eye's lens capsule and a gullet extending at least partially through the cortex of the lens. The lens is then refilled with a synthetic lens material. Sufficient lens core is left in place so that the synthetic material is not in contact with a lens capsule of the eye. The synthetic material used for refilling may be selected and may be formed in a shape and thickness so as to affect the refractive characteristics of the lens. An endocapsular lenticule may be inserted in the lens to affect the refractive characteristics of the lens.

Abstract: An ophthalmic refractor is described that provides a non-linear relationship between spherical power and refractive error by positioning a reference plane for a sensor system of the refractor in front of the cornea. The refractor may have a working distance and dynamic range that enable it to be mounted on a surgical microscope. Also described are computational methods for analysing the output from the ophthalmic refractor, utilising error minimisation, linear regression and Fourier Transform analysis.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releasably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.

Abstract: A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and/or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region and having a biasing configuration structured to be disposed in contacting relation with the iris and/or iridocorneal angle in biasing relation of the central region against the posterior cornea.

Abstract: A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and/or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea.

Abstract: A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included coupled to the base element. An OCT imaging apparatus is also included coupled to the base element. An X-Y scanner is also included coupled to the base element in communication with the OCT imaging apparatus.

Abstract: A method of inserting and securing a corneal implant in engaging and fluid-flow limiting relation to the posterior cornea, such as to treat edema. The method includes securing a corneal implant in fluid flow limiting relation to the posterior cornea through an incision in the eye and securing it in place by a variety of steps such as corneal insertion or laser bonding, and preferably by inserting a removable corneal implant including a central region and a plurality of retention member(s) disposed on the periphery thereof into the eye so as to releaseably and removably engage a portion of the eye and thereby retain the corneal implant in abutting and engaging relation with the posterior cornea. The retention members of the corneal implant may also comprise haptic leg(s) extending from the central region and having a biasing configuration structured to be disposed in contacting relation with the iris and/or iridocorneal angle in biasing relation of the central region against the posterior cornea.