Patents by Inventor Jean-Michel Brunel

Jean-Michel Brunel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190262362
    Abstract: A compound of formula (I) in which R? represents a group —(CRaRb)n—X—(CRcRd)m—[Y—(CReRf)o]t—NR9R10 and X and Y independently represent a group —NR11-, a group —O— or a divalent 5-membered or 6-membered heterocyclic group comprising at least one nitrogen atom, and also the stereoisomers, mixtures of stereoisomers, and/or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical or veterinary compositions containing the compound of formula (I) and also to the use thereof as medicament, more particularly in the treatment of bacterial, fungal, viral or parasitic infections. Also further disclosed are pharmaceutical or veterinary compositions including the compound of formula (I) in combination with an antibiotic other than such a compound of formula (I).
    Type: Application
    Filed: September 15, 2017
    Publication date: August 29, 2019
    Inventors: Jean-Michel BRUNEL, Marine BLANCHET, Jean-Pascal MARC
  • Publication number: 20190255073
    Abstract: A compound of formula (I) in which R? represents a group —(CRaRb)n—X—(CRcRd)m—[Y—(CReRf)o]t—NR9R10 and X and Y independently represent a group —NR11-, a group —O— or a divalent 5-membered or 6-membered heterocyclic group comprising at least one nitrogen atom, and also the stereoisomers, mixtures of stereoisomers, and/or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical or veterinary compositions containing same, which may be used as a medicament, more particularly, in the treatment of bacterial, fungal, viral or parasitic infections. In certain aspects, these pharmaceutical or veterinary compositions include the compound of formula (I) in combination with an antibiotic other than such a compound of formula (I).
    Type: Application
    Filed: September 15, 2017
    Publication date: August 22, 2019
    Applicant: VIRBAC
    Inventors: Jean-Michel BRUNEL, Marine BLANCHET, Jean-Pascal MARC
  • Publication number: 20180258029
    Abstract: Motuporamine agents having antimicrobial activity and uses thereof.
    Type: Application
    Filed: January 9, 2018
    Publication date: September 13, 2018
    Inventors: Otto PHANSTIEL, IV, Jean-Michel BRUNEL
  • Publication number: 20180042942
    Abstract: The invention relates to compounds of formula (I), to the pharmaceutical compositions comprising same, and to the use thereof in the treatment of bacterial, fungal, viral and parasitic infections or in the treatment of cancer in humans or animals. In formula (I), R1 and R2 are as defined in claim 1.
    Type: Application
    Filed: March 11, 2016
    Publication date: February 15, 2018
    Applicant: VIRBAC
    Inventors: Jean-Michel Brunel, Jean-Pascal Marc
  • Patent number: 9700051
    Abstract: The present invention relates to the use of a compound chosen from squalamine and a squalamine-analog aminosteroid compound as agent for disinfecting an inert material object, in particular for the pre-disinfection of medical, dental, diagnostic or surgical equipment. The present invention also provides an aqueous or water-soluble disinfecting composition beneficial for a use according to the invention, characterized in that as disinfecting active compound it comprises a said antibacterial and antifungal compound selected from squalamine and a said squalamine-analog aminosteroid compound and suitable excipients for a water-soluble or aqueous formulation.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: July 11, 2017
    Assignees: ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, UNIVERSITE D'AIX MARSEILLE, FONDATION MEDITERRANEE INFECTION
    Inventors: Jean-Michel Brunel, Didier Raoult, Jean-Marc Rolain
  • Publication number: 20170015617
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 19, 2017
    Applicants: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CORSE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Felix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 9464032
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: October 11, 2016
    Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CORSE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Félix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 9193699
    Abstract: Provided are compounds of formula (I): wherein R1, R2, R3, R4 and R5 are independently selected from the group comprising, inter aliae, H, optionally substituted, branched or linear C1-C12 alkyl, halogen atom and C1-C12 haloalkyl, and wherein A represents a single bond or an optionally substituted C1-C6 alkylene radical, notably useful for the treatment of human cancers.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: November 24, 2015
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITÉ D'AIX-MARSEILLE, L'INSTITUT PAOLI-CALMETTES
    Inventors: Marc Lopez, Yves Collette, Lynda Mezil, Jean-Michel Brunel, Sebastien Combes
  • Publication number: 20150005274
    Abstract: The present invention relates to the use of a compound chosen from squalamine and a squalamine-analogue aminosteroid compound as agent for disinfecting an inert material object, in particular for the pre-disinfection of medical, dental, diagnostic or surgical equipment. The present invention also provides an aqueous or water-soluble disinfecting composition beneficial for a use according to the invention, characterized in that as disinfecting active compound it comprises a said antibacterial and antifungal compound selected from squalamine and a said squalamine-analogue aminosteroid compound and suitable excipients for a water-soluble or aqueous formulation.
    Type: Application
    Filed: January 4, 2013
    Publication date: January 1, 2015
    Inventors: Jean-Michel Brunel, Didier Raoult, Jean-Marc Rolain
  • Patent number: 8920769
    Abstract: A method for producing hydrogen comprising the steps of: i) contacting a compound (C) comprising one or more groups Si—H with an amine based catalyst in a solvent selected from an alcohol or an aqueous solution, thereby forming hydrogen and a by-product (C1); wherein said amine based catalyst is as defined in claim 1; ii) recovering the obtained hydrogen.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: December 30, 2014
    Assignees: Universite d'Aix-Marseille, Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventor: Jean-Michel Brunel
  • Publication number: 20140296227
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and R5 are independently selected from the group comprising, inter aliae, H, optionally substituted, branched or linear C1-C12 alkyl, halogen atom and C1-C12 haloalkyl, and wherein A represents a single bond or an optionally substituted C1-C6 alkylene radical, notably useful for the treatment of human neoplasms.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 2, 2014
    Inventors: Marc Lopez, Yves Collette, Lynda Mezil, Jean-Michel Brunel, Sebastien Combes
  • Publication number: 20140249122
    Abstract: The present invention relates to novel aminosteroid derivatives substituted in position 3 andor 6, and to the use thereof in the context of the treatment of type 2 diabetes and of insulin resistance.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 4, 2014
    Applicants: UNIVERSITE NICE SOPHIA ANTIPOLIS, UNIVERSITE D'AIX-MARSEILLE, INSERM (Institut National de la Sante Et de la Recherche Medicate), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE
    Inventors: Roland Marinus Theodorus Govers, Jean-Michel Brunel
  • Publication number: 20140128335
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Application
    Filed: February 23, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE DE CORSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Felix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 8642003
    Abstract: The invention relates to a method for producing hydrogen comprising the steps of: i) contacting a compound (C) comprising one or more groups Si—H with a phosphorous based catalyst in the presence of a base in water as solvent, thereby forming hydrogen and a by-product (C1); wherein said phosphorous based catalyst is as defined in claim 1; and ii) recovering the obtained hydrogen.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: February 4, 2014
    Assignees: Universite d'Aix-Marseille, Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventor: Jean-Michel Brunel
  • Publication number: 20130189183
    Abstract: The invention relates to a method for producing hydrogen comprising the steps of: i) contacting a compound (C) comprising one or more groups Si—H with a phosphorous based catalyst in the presence of a base in water as solvent, thereby forming hydrogen and a by-product (C1); wherein said phosphorous based catalyst is as defined in claim 1; and ii) recovering the obtained hydrogen.
    Type: Application
    Filed: February 15, 2011
    Publication date: July 25, 2013
    Applicants: Centre National de la Recherche Scientifique (C.N.R.S.), Universite D'Aix-Marseille
    Inventor: Jean-Michel Brunel
  • Publication number: 20120141365
    Abstract: A method for producing hydrogen comprising the steps of: i) contacting a compound (C) comprising one or more groups Si—H with an amine based catalyst in a solvent selected from an alcohol or an aqueous solution, thereby forming hydrogen and a by-product (C1); wherein said amine based catalyst is as defined in claim 1; ii) recovering the obtained hydrogen.
    Type: Application
    Filed: February 19, 2010
    Publication date: June 7, 2012
    Applicants: Centre National de La Recherche Scientifique (C.N.R.S.), Universite De La Mediterranee Aix-Marseille II
    Inventor: Jean-Michel Brunel
  • Publication number: 20110311439
    Abstract: A method for producing hydrogen (H2) includes the steps consisting in: a) reacting a compound (C) including one or more groups Si—H with a fluoride ions source, thereby forming hydrogen and a by-product (C1); and b) recovering the obtained hydrogen.
    Type: Application
    Filed: December 16, 2009
    Publication date: December 22, 2011
    Applicant: UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II
    Inventor: Jean-Michel Brunel