Patents by Inventor Jean-Michel Henlin

Jean-Michel Henlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230092679
    Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 23, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio
  • MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230081720
    Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
    Type: Application
    Filed: May 19, 2020
    Publication date: March 16, 2023
    Inventors: Matthew T. Burger, Maia Chanrion, Frédéric Colland, Marton Csekei, Lea Delacour, Patrice Desos, Olivier Geneste, Jean-Michel Henlin, Vesela Kostova, Andras Kotschy, Ana Leticia Maragno, Eric McNeill, Mark G. Palermo, Francesca Rocchetti, Jérôme Starck, Bing Yu, Qiang Zhang, Ágnes Proszenyák, Szabolcs Sipos, Zhuoliang Chen, Katsumasa Nakajima, Joseph Anthony D'Alessio, John William Blankenship
  • PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20210290631
    Abstract: wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: June 8, 2021
    Publication date: September 23, 2021
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL, Olivier GENESTE, Imre FEJES, János TATAI, Miklós NYERGES, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Didier DURAND
  • Pyrrole compounds, a process for their preparation and pharmaceutical
    Patent number: 11058689
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: July 13, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 11028070
    Abstract: Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: June 8, 2021
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Mark Dodsworth, Johannes W. G. Meissner, Paul Brough, Imre Fejes, János Tatai, Miklós Nyerges, András Kotschy, Zoltán Szlávik, Olivier Geneste, Arnaud Le Tiran, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Anne-Françoise Guillouzic, Guillaume De Nanteuil
  • ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20200262816
    Abstract: Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 20, 2020
    Inventors: James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Claire WALMSLEY, Mark DODSWORTH, Johannes W.G. MEISSNER, Paul BROUGH, lmre FEJES, János TATAI, Miklós NYERGES, András KOTSCHY, Zoltán SZLÁVIK, Olivier GENESTE, Arnaud LE TIRAN, Thierry LE DIGUARHER, Jean-Michel HENLIN, Jérôme-Benoît STARCK, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL
  • PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20200261464
    Abstract: Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 20, 2020
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Anne-Françoise GUILLOUZIC, Guillaume DE NANTEUIL, Olivier GENESTE, lmre FEJES, János TATAI, Miklós NYERGES, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Didier DURAND
  • Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10688101
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: June 23, 2020
    Assignees: LES LABORATORIES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10689364
    Abstract: Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: June 23, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Mark Dodsworth, Johannes W. G. Meissner, Paul Brough, Imre Fejes, János Tatai, Miklós Nyerges, András Kotschy, Zoltán Szlávik, Olivier Geneste, Arnaud Le Tiran, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Anne-Françoise Guillouzic, Guillaume De Nanteuil
  • Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10662173
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: May 26, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Patrick Casara, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190359595
    Abstract: Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Guillaume DE NANTEUIL, Olivier GENESTE, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN
  • Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10414754
    Abstract: Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: September 17, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen
  • PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20190192528
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 27, 2019
    Inventors: Arnaud LE TIRAN, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10265323
    Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: April 23, 2019
    Assignees: LES LABORATOIRES SERVIER, VERNALS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jérôme-Benoît Starck, Jean-Michel Henlin, Anne-Françoise Guillouzic, Guillaume De Nanteuil, Olivier Geneste, Imre Fejes, János Tatai, Miklós Nyerges, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Didier Durand
  • Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10258626
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: April 16, 2019
    Assignees: LES LABORATORIES SERVIER, VERNALIS (R&D) LTD
    Inventors: Thierry Le Diguarher, Patrick Casara, Jérôme-Benoît Starck, Jean-Michel Henlin, James Edward Paul Davidson, James Brooke Murray, Christopher John Graham, I-Jen Chen, Olivier Geneste, John Hickman, Stéphane Depil, Arnaud Le Tiran, Mikl{dot over (o)}s Nyerges, Guillaume De Nanteuil
  • INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20180186771
    Abstract: Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: February 27, 2018
    Publication date: July 5, 2018
    Inventors: Arnaud LE TIRAN, Thierry LE DIGUARHER, Jérôme-Benoît STARCK, Jean-Michel HENLIN, Guillaume DE NANTEUIL, Olivier GENESTE, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN
  • Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9944620
    Abstract: Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: April 17, 2018
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Arnaud Le Tiran, Thierry Le Diguarher, Jéròme-Benoît Starck, Jean-Michel Henlin, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen
  • INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20170342051
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Application
    Filed: August 14, 2017
    Publication date: November 30, 2017
    Inventors: Patrick CASARA, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9809574
    Abstract: Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: November 7, 2017
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Mark Dodsworth, Johannes W. G. Meissner, Paul Brough, Imre Fejes, János Tatai, Miklós Nyerges, András Kotschy, Zoltán Szlávik, Olivier Geneste, Arnaud Le Tiran, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Anne-Françoise Guillouzic, Guillaume De Nanteuil
  • Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9765056
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: September 19, 2017
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Patrick Casara, Thierry Le Diguarher, Jean-Michel Henlin, Jéröme-Benoit Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford