Patents by Inventor Jean-Philippe Leclerc

Jean-Philippe Leclerc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190263786
    Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 29, 2019
    Applicant: GENENTECH, INC.
    Inventors: Daniel SUTHERLIN, Steven MCKERRALL, Kwong Wah LAI, Zhiguo LIU, Wenfeng LIU, Ramsay BEVERIDGE, Jean-Philippe LECLERC, Alexandre LEMIRE, Liang ZHAO, Claudio STURINO
  • Patent number: 9168248
    Abstract: Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: October 27, 2015
    Assignee: Merck Canada Inc.
    Inventors: Nicolas Lachance, Jean-Philippe Leclerc, Chun Sing Li, Oscar Miguel Moradei
  • Publication number: 20140155224
    Abstract: Invention to drive the handling of a hockey stick (the Stick Handling) by strengthening the hand's pronator and supinator muscles in order to improve the control, speed, strength and technique for handling a hockey puck. The exerciser primarily use is to isolate the pronation-supination movement so younger and older users, experts and beginners, professional and amateur are able to develop and identify the most accurate gesture to perform perfectly puck dribbling. The flexion-extension of the elbow is a common mistake among hockey players and can therefore be avoided. Thereafter, when the correct movement is well assimilated, the exerciser can be used to improve the movement quality, speed and/or strength.
    Type: Application
    Filed: November 20, 2013
    Publication date: June 5, 2014
    Inventors: Jean-philippe Leclerc, Marc Leclerc
  • Patent number: 8383643
    Abstract: Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: February 26, 2013
    Assignee: Merck Canada Inc.
    Inventors: Jean-Philippe Leclerc, Chun-Sing Li, Oscar Miguel Moradei
  • Publication number: 20120122912
    Abstract: Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Application
    Filed: July 21, 2010
    Publication date: May 17, 2012
    Inventors: Jean-Philippe Leclerc, Chun-Sing Li, Oscar Miguel Moradei
  • Publication number: 20110312952
    Abstract: Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 22, 2011
    Inventors: Nicolas Lachance, Jean-Philippe Leclerc, Chun Sing Li, Oscar Miguel Moradei
  • Publication number: 20110301143
    Abstract: Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, C?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.
    Type: Application
    Filed: February 18, 2010
    Publication date: December 8, 2011
    Inventors: Elise Isabel, Nicolas Lachance, Jean-Philippe Leclerc, Serge Leger, Renata M. Oballa, David Powell, Yeeman K. Ramtohul, Patrick Roy, Geoffrey K. Tranmer, Renee Aspiotis, Lianhai Li, Evelyn Martins
  • Patent number: 8063224
    Abstract: Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: November 22, 2011
    Assignee: Merck Canada Inc.
    Inventors: Nicolas Lachance, Chun Sing Li, Jean-Philippe Leclerc, Yeeman K. Ramtohul
  • Publication number: 20110166152
    Abstract: Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 7, 2011
    Inventors: Jean-Philippe Leclerc, Chun Sing Li, Yeeman K. Ramtohul
  • Publication number: 20110152295
    Abstract: Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Application
    Filed: September 2, 2009
    Publication date: June 23, 2011
    Inventors: Jean-Philippe Leclerc, Chun Sing Li, Yeeman K. Ramtohul
  • Publication number: 20100249192
    Abstract: Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.
    Type: Application
    Filed: December 9, 2008
    Publication date: September 30, 2010
    Inventors: Chun Sing Li, Yeeman K. Ramtohul, Jean-Philippe Leclerc
  • Publication number: 20100197692
    Abstract: Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
    Type: Application
    Filed: July 18, 2008
    Publication date: August 5, 2010
    Inventors: Yeeman K. Ramtohul, Chun Sing Li, Jean-Philippe Leclerc
  • Publication number: 20080132698
    Abstract: Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3
    Type: Application
    Filed: November 30, 2006
    Publication date: June 5, 2008
    Inventors: Keith Fagnou, Jean-Philippe Leclerc, Louis-Charles Campeau, David R. Stuart
  • Publication number: 20080132542
    Abstract: Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
    Type: Application
    Filed: November 30, 2007
    Publication date: June 5, 2008
    Inventors: Nicolas Lachance, Chun Sing Li, Jean-Philippe Leclerc, Yeeman K. Ramtohul