Patents by Inventor Jean-Philippe Loeffler

Jean-Philippe Loeffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210077453
    Abstract: Inhibitors of glucosylceramide degradation, to pharmaceutical compositions containing same and to the use of same in the treatment of diseases of the motor units, such as amyotrophic lateral sclerosis.
    Type: Application
    Filed: September 29, 2020
    Publication date: March 18, 2021
    Inventors: Michael SPEDDING, Alexandre HENRIQUES, Jean-Philippe LOEFFLER
  • Publication number: 20190142782
    Abstract: Inhibitors of glucosylceramide degradation, to pharmaceutical compositions containing same, and to the use of same in the treatment of diseases of the motor units, such as amyotrophic lateral sclerosis.
    Type: Application
    Filed: April 11, 2017
    Publication date: May 16, 2019
    Inventors: Michael SPEDDING, Alexandre HENRIQUES, Jean-Philippe LOEFFLER
  • Publication number: 20120329767
    Abstract: The present invention relates to uses or methods for treating proliferative diseases, in particular cancer, implementing ruthenium compounds, as well as to composition containing same.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 27, 2012
    Inventors: Michel Pfeffer, Christian Gaiddon, Claude Sirlin, Jean-Paul Collin, Jean-Philippe Loeffler
  • Patent number: 8193175
    Abstract: The invention concerns uses or methods for treating proliferative pathologies, in particular cancers, using ruthenium compounds and compositions containing the same. The invention also concerns novel ruthenium compounds, as well as their preparation method.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: June 5, 2012
    Assignee: Universite de Strasbourg
    Inventors: Michel Pfeffer, Claude Sirlin, Jean-Philippe Loeffler, Christian Gaiddon, Pierre Bischoff, Pierre Jeannequin
  • Publication number: 20080051370
    Abstract: The invention concerns uses or methods for treating proliferative pathologies, in particular cancers, using ruthenium compounds and compositions containing the same. The invention also concerns novel ruthenium compounds, as well as their preparation method.
    Type: Application
    Filed: July 13, 2005
    Publication date: February 28, 2008
    Inventors: Michel Pfeffer, Claude Sirlin, Jean-Philippe Loeffler, Christian Gaiddon, Pierre Bischoff, Pierre Jeannequin
  • Patent number: 7166642
    Abstract: A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: January 23, 2007
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Gaby Schmitt, Florence Keyling-Bilger, Celine Girlanda-Junges, Jean-Philippe Loeffler, Bernadette Lutz-Bucher, Jose-Luis Gonzalez de Aguilar, Masashi Yamada, Yukie Suma, Philippe Chabert
  • Patent number: 5616745
    Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 1, 1997
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Behr, Jean-Philippe Loeffler
  • Patent number: 5476962
    Abstract: Intermediate compounds useful for producing transfecting lipopolyamines, comprising: ##STR1## wherein m is an integer between 2 and 6 inclusive, wherein n is an integer between 2 and 5 inclusive, wherein R.sub.5 represents a hydrogen atom or a carboxyl radical but no more than one R.sub.5 represents a carboxyl, the values of m in the different fragments (CH).sub.m may be identical or different, and wherein the symbol Z R.sub.5 represent a group protecting the amine function.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: December 19, 1995
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Behr, Jean-Philippe Loeffler
  • Patent number: 5171678
    Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6; R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.
    Type: Grant
    Filed: April 17, 1990
    Date of Patent: December 15, 1992
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Behr, Jean-Philippe Loeffler