Patents by Inventor Jeannette L. Bennicelli

Jeannette L. Bennicelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proviral plasmids and production of recombinant adeno-associated virus
    Patent number: 9896665
    Abstract: Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of the polyA sequence; and (v) a wildtype 3? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3? ITR.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: February 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jean Bennett, Jeannette L. Bennicelli
  • Proviral Plasmids and Production of Recombinant Adeno-Associated Virus
    Publication number: 20160108373
    Abstract: Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of said ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polyA sequence; and (v) a wildtype 3? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3? ITR. These plasmids enable rapid manipulation of the components of the cassette, e.g.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Inventors: Jean Bennett, Jeannette L. Bennicelli
  • Proviral plasmids and production of recombinant adeno-associated virus
    Patent number: 9249425
    Abstract: Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of said ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polyA sequence; and (v) a wildtype 3? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3? ITR. These plasmids enable rapid manipulation of the components of the cassette, e.g.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: February 2, 2016
    Assignee: The Trustees of the University of Pennslyvania
    Inventors: Jean Bennett, Jeannette L. Bennicelli
  • Proviral Plasmids and Production of Recombinant Adeno-Associated Virus
    Publication number: 20140087444
    Abstract: Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of said ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polyA sequence; and (v) a wildtype 3? AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3? ITR. These plasmids enable rapid manipulation of the components of the cassette, e.g.
    Type: Application
    Filed: May 16, 2012
    Publication date: March 27, 2014
    Inventors: Jean Bennett, Jeannette L. Bennicelli