Abstract: An integrated therapeutic and imaging device that uses at least two balloons to provide a guarded zone that can be evacuated and replaced with a fluid that is sufficiently clear to permit optical coherence tomography (or even high resolution ultrasound) imaging that would otherwise be of poor quality or impossible. Methods of making and operating the imaging device to obtain clear, high quality images, as well as treating a patient's tissue with the device within a living body in association with obtaining an image of the patient's tissue, are included.

Abstract: A method and a system of testing an electrical signal path functionality of a sensing catheter in a dry environment. A variety of test input patterns are generated by an arbitrary near field RF signal generator, transmitted into the sensing catheter disposed in a shielded enclosure. B-mode like images corresponding to the test input patterns are generated and displayed by an imaging system connected to a proximal end of the sensing catheter, and then analyzed by a computer system, as dependent on the frequency, amplitude, and phase of the test input patterns. A determination is made as to whether the sensing catheter retains a desired electrical signal path functionality based on the analysis. The sensing catheter could be a variety of sensing catheters including forward looking catheters, a rotational IVUS catheters, or phased array IVUS catheters.

Abstract: An integrated therapeutic and imaging device that uses at least two balloons to provide a guarded zone that can be evacuated and replaced with a fluid that is sufficiently clear to permit optical coherence tomography (or even high resolution ultrasound) imaging that would otherwise be of poor quality or impossible. Methods of making and operating the imaging device to obtain clear, high quality images, as well as treating a patient's tissue with the device within a living body in association with obtaining an image of the patient's tissue, are included.

Abstract: A gateway data port for coherently transferring multiple-bit input data words in series as part of an input data chain onto an input data line that serially connects the gateway data port and other data ports to a receiver and for coherently transferring multiple-bit output data words from an output data line that serially connects the gateway data port and other data ports to a transmitter. The input data words are provided to the gateway data port asynchronously with the transfer onto the input data line; and the output data words are transmitted over the output data line as part of an output data chain to the gateway data port asynchronously with the transfer from the output data line. The input data words are transferred coherently through an asynchronous receiver and a buffer into an input data shift register, which includes a serial block of adjacent input data register stages defining a plurality of data word bit positions in the input data chain.