Abstract: Systems and methods for limiting functionality of a vehicle are described. In one example, vehicle feature modules may specify vehicle behaviors and vehicle operation is limited according to the specified behaviors. Vehicle actuators may be adjusted to limit vehicle operation according to the specified vehicle behaviors. The vehicle behaviors may apply to powertrain systems, navigation systems, climate control systems, lighting systems and other vehicle systems.

Abstract: Technology is described to provide a powered prosthetic wrist flexion device or elbow device. This device helps individuals with upper-limb loss to orient and position grasped objects.

Abstract: A distractor system for use in a joint between two bone surfaces of an anatomical structure includes, for example, distractor and at least one detachable tool comprising a body having a proximal portion and a distal portion, said proximal portion being releasably attachable to at least one of a first end of the distractor and/or a second end of the distractor. The distal portion of the detachable tool being operably positionable in the joint between the two bone surfaces of the anatomical structure. The detachable tools may include a detachable paddle.

Abstract: A distractor system for use in a joint between two bone surfaces of an anatomical structure includes, for example, distractor and at least one detachable tool comprising a body having a proximal portion and a distal portion, said proximal portion being releasably attachable to at least one of a first end of the distractor and/or a second end of the distractor. The distal portion of the detachable tool being operably positionable in the joint between the two bone surfaces of the anatomical structure. The detachable tools may include a detachable paddle.

Abstract: The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen.

Abstract: Resection guides include a body a plurality of alignment pin through-holes and a plurality of guide through-holes so that the pattern of guide through-holes is operable for receiving a drill for use in resecting the at least a portion of the anatomical structure of the patient. Sweeping reamers include a body having a plurality of alignment pin through-holes and an elongated opening, and a reamer extendable through the elongated opening of the body. Decoupled resection guides include a first body having a plurality of alignment pin through-holes and a second body having a plurality of fixation pin through-holes and at least one guide aperture operable for guiding a cutting tool for use in resecting a portion of the second anatomical structure of the patient. Methods employing the same are disclosed and operable in, for example, total ankle replacement.

Abstract: The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen.

Abstract: Resection guides include a body a plurality of alignment pin through-holes and a plurality of guide through-holes so that the pattern of guide through-holes is operable for receiving a drill for use in resecting the at least a portion of the anatomical structure of the patient. Sweeping reamers include a body having a plurality of alignment pin through-holes and an elongated opening, and a reamer extendable through the elongated opening of the body. Decoupled resection guides include a first body having a plurality of alignment pin through-holes and a second body having a plurality of fixation pin through-holes and at least one guide aperture operable for guiding a cutting tool for use in resecting a portion of the second anatomical structure of the patient. Methods employing the same are disclosed and operable in, for example, total ankle replacement.

Abstract: A distractor system for use in a joint between two bone surfaces of an anatomical structure includes, for example, distractor and at least one detachable tool comprising a body having a proximal portion and a distal portion, said proximal portion being releasably attachable to at least one of a first end of the distractor and/or a second end of the distractor. The distal portion of the detachable tool being operably positionable in the joint between the two bone surfaces of the anatomical structure. The detachable tools may include a detachable paddle.

Abstract: Resection guides include a body a plurality of alignment pin through-holes and a plurality of guide through-holes so that the pattern of guide through-holes is operable for receiving a drill for use in resecting the at least a portion of the anatomical structure of the patient. Sweeping reamers include a body having a plurality of alignment pin through-holes and an elongated opening, and a reamer extendable through the elongated opening of the body. Decoupled resection guides include a first body having a plurality of alignment pin through-holes and a second body having a plurality of fixation pin through-holes and at least one guide aperture operable for guiding a cutting tool for use in resecting a portion of the second anatomical structure of the patient. Methods employing the same are disclosed and operable in, for example, total ankle replacement.

Abstract: Methods for total ankle replacement procedures are disclosed. A method includes making an initial incision, obtaining an alignment guide, performing an alignment, performing a tibia and talar resection, trialing the implant components, performing a talar chamfer resection, and implanting the components.

Abstract: Technology is described to provide a powered prosthetic wrist flexion device or elbow device. This device helps individuals with upper-limb loss to orient and position grasped objects.

Abstract: A customer uses a customer device to interact with an expert using a remote device in a real-time communication session. The expert drives the interactions and can activate peripherals on the customer device to capture information, which is automatically sent from the customer device to the remote device for consumption by the expert.

Abstract: The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen.

Abstract: A thrust reverser system for a gas turbine engine includes a support structure, a transcowl, and an actuator. The transcowl is mounted on the support structure and is axially translatable between a stowed position and a deployed position. The actuator is coupled to the transcowl and the support structure, and is configured to supply an actuation force to the transcowl to thereby move the transcowl between the stowed and deployed positions. The actuator includes an actuator housing, a screw, a nut, a rod end, and a tension rod. The tension rod is engaged by the nut when the transcowl is in the deployed position and is engaged by the rod end when the transcowl is in the stowed position, whereby actuator loads, in both the deployed and stowed positions, are transmitted through the tension rod to the support structure.

Abstract: A pneumatic taxi system of an aircraft with a rotary non-turbine air motor for driving a wheel, of an aircraft landing gear, with compressed air.

Abstract: A thrust reverser system for a gas turbine engine includes a support structure, a transcowl, and an actuator. The transcowl is mounted on the support structure and is axially translatable between a stowed position and a deployed position. The actuator is coupled to the transcowl and the support structure, and is configured to supply an actuation force to the transcowl to thereby move the transcowl between the stowed and deployed positions. The actuator includes an actuator housing, a screw, a nut, a rod end, and a tension rod. The tension rod is engaged by the nut when the transcowl is in the deployed position and is engaged by the rod end when the transcowl is in the stowed position, whereby actuator loads, in both the deployed and stowed positions, are transmitted through the tension rod to the support structure.

Abstract: A thrust reverser system for a gas turbine engine includes a support structure, a transcowl, an actuator, and a retractable cable. The support structure is configured to be mounted to the turbine engine. The transcowl is mounted on the support structure and is axially translatable, relative to the support structure, between a stowed position and a deployed position. The actuator is configured to supply an actuation force to the transcowl to thereby move the transcowl between the stowed and deployed positions. The retractable cable is coupled to the transcowl and the support structure, and is configured to react reverse thrust loads on the transcowl at least when the transcowl is in the deployed position, to thereby at least reduce thrust loading on the actuator.

Abstract: A gearbox for driving a sprocket includes a gear train and an output shaft assembly positioned between the gear train and a power output end of the gearbox. The output shaft assembly includes, a first shaft segment extending to the power output a second shaft segment coupled to the gear train and a torsion spring interposed between the first shaft segment and the second shaft segment. Upon non-conjugate meshing of the sprocket, the torsion spring expands and contracts so that the angular velocity of the second shaft segment differs from the angular velocity of the first shaft segment.

Abstract: A pneumatic taxi system of an aircraft with a rotary non-turbine air motor for driving a wheel, of an aircraft landing gear, with compressed air.