Patents by Inventor Jeffrey Finer

Jeffrey Finer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8324165
    Abstract: The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: December 4, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Kalyani Penta, Srinivas Kothakota, Lewis T. Williams, Kevin Hestir, Shannon Marshall, Jeffrey Finer, Yan Wang
  • Publication number: 20110288024
    Abstract: The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 24, 2011
    Applicant: Five Prime Therapeutics, Inc.
    Inventors: Kalyani Penta, Srinivas Kothakota, Lewis (Rusty) T. Williams, Kevin Hestir, Shannon Marshall, Jeffrey Finer, Yan Wang
  • Publication number: 20100183620
    Abstract: The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or ?-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
    Type: Application
    Filed: November 25, 2009
    Publication date: July 22, 2010
    Inventors: KAUMUDI BHAWE, Elizabeth Bosch, Kathleen Boyle, Arthur Brace, Anuk Das, Francis Farrell, Pitchumani Sivakumar, Jeffrey Finer, Kristen Pierce, Kathleen M. Sullivan, Brian Wong
  • Patent number: 7671200
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: March 2, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey Finer, Gustave Bergnes, Bainian Feng, Whitney Smith, John Chabala
  • Publication number: 20070259390
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 23, 2007
    Publication date: November 8, 2007
    Applicant: Cytokinetics,Inc.
    Inventors: James Hartman, Fady Malik, Roman Sakowicz, Jeffrey Finer
  • Publication number: 20070254310
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: January 18, 2007
    Publication date: November 1, 2007
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Publication number: 20070254902
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: April 17, 2007
    Publication date: November 1, 2007
    Inventors: Jeffrey Finer, Gustav Bergnes, Whitney Smith, John Chabala, Bainian Feng
  • Publication number: 20060257962
    Abstract: The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or serve as modulators of the biological activity of a target protein.
    Type: Application
    Filed: December 6, 2005
    Publication date: November 16, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Ramesh Baliga, Donglin Guo, Daniel Pierce, Jeffrey Finer
  • Publication number: 20060014736
    Abstract: Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.
    Type: Application
    Filed: September 16, 2005
    Publication date: January 19, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey Finer, John Chabala
  • Publication number: 20060003399
    Abstract: Methods for assaying for actin polymerization are described, as are the use of the assays to screen for modulators of actin polymerization. The screening methods can be utilized to identify active agents that interact with actin, the polymerization state of actin and other proteins or cellular components whose function is naturally or artificially coupled to actin polymerization or depolymerization. Protein constructs and kits useful in performing the methods are also provided.
    Type: Application
    Filed: June 10, 2005
    Publication date: January 5, 2006
    Applicant: Cytokinetics, Inc.
    Inventors: Nenad Tomasevic, Zhiheng Jia, Roman Sakowicz, Daniel Pierce, Jeffrey Finer
  • Publication number: 20050266511
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 7, 2005
    Publication date: December 1, 2005
    Applicant: Cytokinetics, Inc.
    Inventors: James Hartman, Fady Malik, Roman Sakowicz, Jeffrey Finer
  • Publication number: 20050187232
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: March 21, 2005
    Publication date: August 25, 2005
    Inventors: Jeffrey Finer, Gustave Bergnes, Whitney Smith, John Chabala, Bainian Feng
  • Patent number: 5512745
    Abstract: By providing a focal region of light onto a particle, a laser-based light source can provide enough radiation pressure to position the particle at any desired location in space. In one application, the particle can be a micrometer-sized bead, called a handle, attached to a sample. When the sample under examination, such as an actin filament, interacts with other molecules, such as myosin, the forces generated may displace the sample, and thus the handle, out of its original position. To correct for the off-target position (or in other words, to increase the stiffness of the handle), a feedback loop that utilizes a quadrant photodiode detector and a focal region location means such as an acousto-optic modulator or galvanometer mirror is incorporated in the optical trap system. Use of two other light sources for brightfield illumination and epifluorescence allows the simultaneous viewing of the sample in real time. In other embodiments, the optical trap system can trap and manipulate particles.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: April 30, 1996
    Assignee: Board of Trustees of the Leland Stanford Jr. University
    Inventors: Jeffrey Finer, Robert Simmons, James A. Spudich, Steven Chu