Patents by Inventor Jeffrey I. Cohen

Jeffrey I. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240174735
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus (EBV) infection in mammals, and methods of using those compositions of matter for the detection, diagnosis and treatment of EBV infection are described. Also described are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Application
    Filed: February 13, 2024
    Publication date: May 30, 2024
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
  • Patent number: 11926656
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus (EBV) infection in mammals, and methods of using those compositions of matter for the detection, diagnosis and treatment of EBV infection are described. Also described are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: March 12, 2024
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
  • Publication number: 20230348568
    Abstract: Monoclonal antibodies that specifically bind gp42 of Epstein-Barr virus (EBV) are described. The antibodies are capable of blocking fusion of EBV-infected cells and neutralizing EBV infection. Use of the EBV-specific monoclonal antibodies, and conjugates thereof, for the treatment and prophylaxis of EBV infection is also described.
    Type: Application
    Filed: February 19, 2021
    Publication date: November 2, 2023
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Jeffrey I. Cohen, Wei Bu, Nathan Board, Kennichi Dowdell
  • Publication number: 20220193227
    Abstract: The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 23, 2022
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Jeffrey I. Cohen, Lesley Pesnicak
  • Patent number: 11305009
    Abstract: The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: April 19, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jeffrey I. Cohen, Lesley Pesnicak
  • Publication number: 20220098284
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus infection in mammals, and methods of using those compositions of matter for the same are disclosed. Also disclosed are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 31, 2022
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
  • Patent number: 11236151
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus infection in mammals, and to methods of using those compositions of matter for the same. Also disclosed are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: February 1, 2022
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Wei Bu, Masaru Kanekiyo, Michael Gordon Joyce, Jeffrey I. Cohen
  • Publication number: 20210171610
    Abstract: Anti-EBV gH antibodies, anti-EBV gL antibodies, anti-EBV gH/gL antibodies, and compositions of matter useful for the detection, diagnosis, prevention, and treatment of Epstein Barr Virus infection in humans, and methods of using those compositions of matter for the same.
    Type: Application
    Filed: May 2, 2019
    Publication date: June 10, 2021
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Masaru Kanekiyo, Michael Gordon Joyce, Wei Bu, Jeffrey I. Cohen, Yaroslav Tsybovsky
  • Publication number: 20200190168
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Epstein Barr Virus infection in mammals, and to methods of using those compositions of matter for the same. Also disclosed are proteins, referred to as anti-gp350 antibody probes, and anti-gp350 B-cell probes, that maintain the epitope structure of the CR2-binding region of gp350, but do not bind CR2.
    Type: Application
    Filed: April 25, 2018
    Publication date: June 18, 2020
    Inventors: Wei BU, Masaru KANEKIYO, Michael Gordon JOYCE, Jeffrey I. COHEN
  • Publication number: 20190167784
    Abstract: The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
    Type: Application
    Filed: November 19, 2018
    Publication date: June 6, 2019
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Jeffrey I. Cohen, Lesley Pesnicak
  • Patent number: 10166285
    Abstract: The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: January 1, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Jeffrey I. Cohen, Lesley Pesnicak
  • Patent number: 8916175
    Abstract: Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: December 23, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Jeffrey I. Cohen, Edward M. Cox, Jr., Lesley M. Pesnicak
  • Publication number: 20130209506
    Abstract: The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
    Type: Application
    Filed: November 9, 2007
    Publication date: August 15, 2013
    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the secretary of the department of
    Inventors: Jeffrey I. Cohen, Lesley Pesnicak
  • Patent number: 7539704
    Abstract: A method, system, and computer-readable medium are provided for displaying contents of a database table comprising a plurality of fields arranged in a plurality of rows and columns, selecting a field of the plurality of fields wherein the selected field comprises a reference to an attached file, and opening the attached file in response to the selecting. A row of the plurality of rows of the database table is associated with an attached file. A column of the plurality of columns comprises information about the attached files associated with the rows.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: May 26, 2009
    Assignee: Siebel Systems, Inc.
    Inventors: Robert A. Brodersen, Prashant Chatterjee, Jeffrey I. Cohen, Peter Siam Sy Lim, III
  • Publication number: 20080279886
    Abstract: Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety.
    Type: Application
    Filed: June 22, 2005
    Publication date: November 13, 2008
    Applicant: The Govt. of the U.S.A. as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Jeffrey I. Cohen, Edward M. Cox, JR., Lesley M. Pesnicak
  • Publication number: 20040162853
    Abstract: Attaching files and other objects in a distributed computing environment. This includes adding file attachments and non-database objects, such as, text file data, web file data, image file data, and other file attachment objects to databases. These objects may be retrieved at the convenience of a node to which the objects are sent. Visibility rules can be set to determine which attachments and objects are seen by a node. Distribution rules for an object determine whether a node must request the object or whether the node is forced to receive the object.
    Type: Application
    Filed: October 29, 2003
    Publication date: August 19, 2004
    Inventors: Robert A. Brodersen, Prashant Chatterjee, Jeffrey I. Cohen, Peter Siam Sy Lim
  • Patent number: 6732111
    Abstract: Attaching files and other objects in a distributed computing environment. This includes adding file attachments and non-database objects, such as, text file data, web file data, image file data, and other file attachment objects to databases. These objects may be retrieved at the convenience of a node to which the objects are sent. Visibility rules can be set to determine which attachments and objects are seen by a node. Distribution rules for an object determine whether a node must request the object or whether the node is forced to receive the object.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: May 4, 2004
    Assignee: Siebel Systems, Inc.
    Inventors: Robert A. Brodersen, Prashant Chatterjee, Jeffrey I. Cohen, Peter Siam Sy Lim III
  • Publication number: 20030191743
    Abstract: Attaching files and other objects in a distributed computing environment. This includes adding file attachments and non-database objects, such as, text file data, web file data, image file data, and other file attachment objects to databases. These objects may be retrieved at the convenience of a node to which the objects are sent. Visibility rules can be set to determine which attachments and objects are seen by a node. Distribution rules for an object determine whether a node must request the object or whether the node is forced to receive the object.
    Type: Application
    Filed: April 4, 2003
    Publication date: October 9, 2003
    Applicant: Siebel Systems, Inc.
    Inventors: Robert A. Brodersen, Prashant Chatterjee, Jeffrey I. Cohen, Peter Siam Sy Lim
  • Patent number: 6266662
    Abstract: A method and apparatus for segmenting bitmaps in a bitmap index is provided. A segmented bitmap includes a plurality of bitmap segments that are used to indicate which records in a body of records that is associated with the segmented bitmap satisfy a particular criteria. Each bitmap segment contains a string of bits that correspond to a corresponding range of records in the body of records. There may be gaps between the ranges represented by the bitmap segments when, for example, the body of records does not contain records in a particular range. For the purposes of retrieval, compression, de-compression, locking and logging, the database system treats each bitmap segment as a distinct data item.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: July 24, 2001
    Assignee: Oracle Corporation
    Inventors: Cetin Ozbutun, Jeffrey I. Cohen, Hakan Jakobsson, Michael Depledge, Alexander C. Ho
  • Patent number: RE37381
    Abstract: The present invention provides an attenuated hepatitis A virus useful as a vaccine.
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: September 18, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert H. Purcell, John R. Ticehurst, Jeffrey I. Cohen, Suzanne U. Emerson, Stephen M. Feinstone, Richard J. Daemer, Ian D. Gust