Abstract: Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.

Abstract: Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.

Abstract: Described herein are therapeutic combinations with estrogen receptor modulators for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A dispensing device comprising a container with product outlets, a screw that operates a piston within the container and a torsion spring that biases the screw. The torsion spring includes a hoop having one or more inner tabs. The hoop is frictionally engaged with an interior surface of the container. A boss is fixed to the screw and a flexible arm interconnects the hoop and boss. The torsion spring also includes a spoke that is angularly offset from the flexible arm. Application of a rotational force to the screw urges the piston toward the container outlets, causing the flexible arm to yield, allowing the boss to rotate relative to the hoop until the spoke engages an inner tab. Further rotation releases the hoop from frictional engagement with the container. Once the rotational force is removed, the hoop re-engages the container interior surface and the flexible arm regains its original shape, causing the hub and screw to counter-rotate, which simultaneously moves the piston away from the fluid outlets.

Abstract: An axially oriented detent system interacting between a contact plug housing and a coaxial coupling ring. The coupling ring includes an inner peripheral rib that provides an axially outwardly facing shoulder. Detent springs or a detent washer with resilient detent elements engage the serrated face of a cover part. The cover part is secured to the sleeve so that the springs or elements move across the face during rotation of the coupling ring. The springs and elements have flexible arms that incline from a base apex to a distal free end. Movement of the serrations from the free end toward the apex creates a compression force that is absent when the serrations move in opposite direction. As such, the system creates a resistance to rotational decoupling that exceeds the resistance to coupling.

Abstract: The inner end surface of the outer end portion of an electrical connector coupling ring has a set of teeth extending circumferentially about the coupling ring. A metal ring has a bore sufficient to enable it being received onto the connector plug and an outer diameter sufficient to enable receipt within the coupling ring and allow the coupling ring to rotate thereabout. One or more keyways on the decoupling ring are interlocked with keys on the connector plug maintaining the antidecoupling ring and plug in fixed relationship to one another, irrespective of movement of the coupling ring. At least one elongated leaf spring has an end formed into a detent that rides along and between the coupling ring teeth. The other spring end is rotatably located on a pivot pin mounted to the circumferential periphery of the anti-decoupling ring.

Abstract: The outer insulation on a cable to be terminated is removed leaving a section of exposed cable shield. An annular metal contact with a deformable circumferential flange is received on the cable and affixed (soldered) to the bare shield completely encircling the shield with a mechanical and electrical connection. A receiving tube slid onto the cable has a contoured end for receipt under the contact flange. A clamping ring is soldered, mechanically or electromagnetically formed over the flange and contoured end of the receiving tube.A cylindrical cap encloses the bare shield section and contact with thin-wall portions being deformed to tightly engage the receiving tube. The cable and outer end of the receiving tube are passed through an opening in a termination plate (e.g., ship deck) and the receiving tube is welded to the plate.

Abstract: A cylindrical rubber or elastomeric gasket which is L-shaped in cross-section having an outwardly extending rim or flange is initially located between a cylindrical backshell and a connector part which the backshell is to be magnetically clamped. The internal diameter of the seal closely approximates the major diameter of the connector part. The backshell end is slid onto the connector part and, more particularly, onto and over the seal with the seal flange extending around the end of the backshell with its outermost surface abutting against a flange on the connector part. The seal in this way accomplishes both aligning of the backshell with the axis of the connector part for the electromagnetic forming step and, as well, effects environmental sealing after the backshell is fully in place.

Abstract: Cable wires to be interconnected by a plug and receptacle connector are received within the end portion of each connector part, the cables themselves being conventionally connected to a pin and socket contacts. The contacts are received within insulative inserts which, in turn, are mounted within metal shell members. A portion of the cable shields outwardly of the insulative inserts are located on the outer end portion of a connector part metal shell surrounding the inserts. A metal ring is placed over the individual cable shields and formed in place mechanically securing and electrically connecting the cable shields to the metal cylinder and thus to the connector part.