Abstract: A method of screening a composition for cardiotoxicity comprising contacting the composition with cardiomyocytes that have increased fatty acid oxidation and/or diminished glucose oxidation. The cardiomyocytes are preferably prepared by overexpression of COX7A1. The cardiomyocytes are preferably provided in a micropatterned co-culture to provide a mature functional hPSC-CM cardiotoxicity model.

Abstract: The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.

Abstract: A light sensitive media packaging with unique shrink-wrap light protection label that works as a light barrier to protect media from light damage.

Abstract: The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.

Abstract: A database system includes a processor configured to receive broadcasts according to a plurality of broadcast formats. The processor determines broadcast information associated with each received broadcast. The processor stores a database entry for each received broadcast within a database stored in the memory. Each database entry is indicative of the broadcast information associated the received broadcast. The processor continuously populates the database with broadcast information associated with received broadcasts. The database is user-accessible, allowing database entries to be viewed and altered. Ratings for various broadcast information are user-provided allowing preferred broadcast content to be user-designated based on the broadcast information. The ratings are used to notify a user of preferred broadcast content being broadcast according to at least one of the broadcast formats allowing the user to select receipt of the preferred broadcast content while available.

Abstract: The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.

Abstract: The disclosure provides methods for isolating a pure or enriched population of differentiated cells derived from stem cells, comprising differentiating the population of stem cells; and migrating the differentiated cells through a porous membrane in a differentiation device to isolate the pure or enriched population of differentiated cells. The disclosure also provides a differentiation device for isolating a pure or enriched population of differentiated cells derived from stem cells, the device comprising a porous membrane; and an extracellular matrix.

Abstract: A light sensitive media packaging with unique shrink-wrap light protection label that works as a light barrier to protect media from light damage.

Abstract: A light sensitive media packaging with unique shrink-wrap light protection label that works as a light barrier to protect media from light damage.

Abstract: A database system includes a processor configured to receive broadcasts according to a plurality of broadcast formats. The processor determines broadcast information associated with each received broadcast. The processor stores a database entry for each received broadcast within a database stored in the memory. Each database entry is indicative of the broadcast information associated the received broadcast. The processor continuously populates the database with broadcast information associated with received broadcasts. The database is user-accessible, allowing database entries to be viewed and altered. Ratings for various broadcast information are user-provided allowing preferred broadcast content to be user-designated based on the broadcast information. The ratings are used to notify a user of preferred broadcast content being broadcast according to at least one of the broadcast formats allowing the user to select receipt of the preferred broadcast content while available.

Abstract: The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.

Abstract: A light sensitive media packaging with unique shrink-wrap light protection label that works as a light barrier to protect media from light damage.

Abstract: Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of O2 tension, including manipulation of Ca2+ under high O2 tension and contacting oocytes with serine threonine kinase inhibitors under low O2 tension, isolating inner cell masses (ICMs) from the activated oocytes, and culturing the cells of the isolated ICMs under high O2 tension. Moreover, methods are described for the production of stems cells from activated oocytes in the absence of non-human animal products, including the use of human feeder cells/products for culturing ICM/stem cells. Stem cells produced by the disclosed methods are also described.