Patents by Inventor Jeffrey L. Platt

Jeffrey L. Platt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190144514
    Abstract: The present invention relates to the treatment of cancer and to the prevention of cancer growth and/or metastasis. In particular, the invention relates to cellular and acellular vaccines containing C3d, a proteolytic product of complement (C3), and methods of enhancing a host immune response (e.g., a T cell mediated immune response) against cancers using same. Compositions and methods of the invention find use, alone or in conjunction with other cancer therapies, in treating lymphoma and/or cancers that develop and/or persist by evading host immune surveillance and/or responses (e.g., T-cell mediated immune responses). Compositions and methods of the invention find use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
    Type: Application
    Filed: April 18, 2017
    Publication date: May 16, 2019
    Inventors: Marilia Cascalho, Jeffrey L. Platt
  • Patent number: 8153592
    Abstract: This description provides methods and materials related to modulating Toll-like receptor activity. For example, methods and materials for increasing or decreasing the responsiveness of a TLR4 polypeptide are provided.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: April 10, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jeffrey L. Platt, Gregory J. Brunn
  • Publication number: 20110107441
    Abstract: Methods for identifying animals as having reduced body fat and increased bone density are provided herein. Also provided herein are methods for generating animals having reduced body fat and increased bone density. The methods provided herein are based on the effect of TLR4, MD-2, and CD14 activity on body fat and bone density.
    Type: Application
    Filed: July 6, 2009
    Publication date: May 5, 2011
    Inventors: Geoffrey B. Johnson, Jeffrey L. Platt, Joel W. Johnson
  • Patent number: 7776321
    Abstract: The invention relates to methods and materials useful for targeting antigenic determinants of mutable pathogens for somatic hypermutation. These methods and materials can be used to induce an immune response against antigenic variants of mutable pathogens.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: August 17, 2010
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Marilia I. Cascalho, Jeffrey L. Platt
  • Publication number: 20100158808
    Abstract: Materials and Methods for modulating TLR activity are described, as well as methods for reducing body fat and increasing bone density.
    Type: Application
    Filed: December 8, 2009
    Publication date: June 24, 2010
    Inventors: Jeffrey L. Platt, Geoffrey B. Johnson, Gregory J. Brunn
  • Publication number: 20090138976
    Abstract: The current document relates to transgenic rodents that have a nucleic acid molecule encoding a hepatocyte mitogen polypeptide.
    Type: Application
    Filed: September 29, 2005
    Publication date: May 28, 2009
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Michael R. Charlton, Jeffrey L. Platt
  • Publication number: 20090111746
    Abstract: This description provides methods and materials related to modulating Toll-like receptor activity. For example, methods and materials for increasing or decreasing the responsiveness of a TLR4 polypeptide are provided.
    Type: Application
    Filed: January 10, 2006
    Publication date: April 30, 2009
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Jeffrey L. Platt, Gregory J. Brunn
  • Publication number: 20080038253
    Abstract: Methods and materials for enhancing T cell diversity are described. For example, methods that include administering purified populations of B cells or immunoglobulins to subjects in need thereof are provided.
    Type: Application
    Filed: March 4, 2005
    Publication date: February 14, 2008
    Inventors: Marilia I. Cascalho, Jeffrey L. Platt
  • Publication number: 20040242517
    Abstract: The invention relates to methods and materials useful for targeting antigenic determinants of mutable pathogens for somatic hypermutation. These methods and materials can be used to induce an immune response against antigenic variants of mutable pathogens.
    Type: Application
    Filed: March 25, 2004
    Publication date: December 2, 2004
    Inventors: Marilia I Cascalho, Jeffrey L Platt