Abstract: Disclosed are combinations of soy protein and chromium in amounts effective to inhibit the loss of lean body mass of a subject under caloric restriction. Further combinations include corosolic acid and optionally additional chromium. Still further combinations include a dietary composition of Fucus vesiculosus, Gambogia garcinia, Apis mellifica, Badiaga, Calcarea carbonica, Passiflora incarnata, Baryta carbonica, Calcarea fluorica, Lycopodium clavatum, Berberis vulgaris, Leptandra virginica, Thuja occidentalis, Galium aparine, Urtica urens, Histaminum muriaticum, and Sabadilla. Compositions of the disclosed soy protein, chromium, and corosolic acid combinations are disclosed as are kits containing the disclosed combinations as well as methods of using the disclosed combinations and compositions for weight loss and the inhibition of the loss of lean body mass in a subject during weight loss.