Patents by Inventor Jeffrey R. Shuster
Jeffrey R. Shuster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130217647Abstract: Biomarkers (and suites of biomarkers) relating to prostate cancer are provided, as well as methods for using such biomarkers (ans suites thereof), including early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy.Type: ApplicationFiled: July 27, 2011Publication date: August 22, 2013Applicant: METABOLON, INC.Inventors: Jeffrey R. Shuster, Matthew W. Mitchell, Jonathan E. McDunn, Bruce Neri
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Publication number: 20080254496Abstract: The present invention describes the use of enzymes having D-arabinitol oxidase activity with the concomitant generation of hydrogen peroxide for the diagnosis of fungal infections of humans and other organisms, and for the detection of fungal organisms that are present on or in surfaces or permeable materials. The present invention also describes methods and kits for the detection of fungi, and the diagnosis of fungal infections based upon D-arabinitol oxidase activity. The present invention also provides a new biochemical activity for gene products encoded by bacterial genes previously identified only with putative function. Activity of these gene products includes the ability to oxidize D-arabinitol with the concomitant generation of hydrogen peroxide.Type: ApplicationFiled: September 26, 2006Publication date: October 16, 2008Inventor: Jeffrey R. Shuster
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Patent number: 7198938Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: GrantFiled: June 30, 2004Date of Patent: April 3, 2007Assignee: Novozymes, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Patent number: 7186513Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: August 29, 2003Date of Patent: March 6, 2007Assignee: Novozymes, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 7163804Abstract: The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.Type: GrantFiled: December 15, 1999Date of Patent: January 16, 2007Assignee: Novozymes, Inc.Inventors: John C. Royer, Donna L. Moyer, Jeffrey R. Shuster, Yoder T. Wendy
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Patent number: 6902887Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: March 22, 2000Date of Patent: June 7, 2005Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Publication number: 20040266009Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: ApplicationFiled: June 30, 2004Publication date: December 30, 2004Applicant: Novozymes Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Publication number: 20040248773Abstract: The present inventors have discovered that pyrroline-5-carboxylate reductase is essential for normal fungal pathogenicity. Specifically, the inhibition of pyrroline-5-carboxylate reductase gene expression in fungi results in drastically reduced pathogenicity. Thus, pyrroline-5-carboxylate reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit pyrroline-5-carboxylate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.Type: ApplicationFiled: December 19, 2003Publication date: December 9, 2004Inventors: Matthew M. Tanzer, Jeffrey R. Shuster, Todd M. DeZwaan, Sheryl A. Frank, Maria V. Montenegro-Chamorro, Ryan W. Heiniger, Amy S. Covington, Lisbeth Hamer, Kiichi Adachi, Sze-Chung Lo, Blaise A. Darveaux, Sanjoy K. Mahanty, Huaqin Pan, Rex Tarpey
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Publication number: 20040229367Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: ApplicationFiled: August 29, 2003Publication date: November 18, 2004Applicants: Novozymes Biotech, Inc., Novozymes A/S, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 6794180Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: GrantFiled: February 25, 2003Date of Patent: September 21, 2004Assignee: Novozymes Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Publication number: 20040009579Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: ApplicationFiled: February 25, 2003Publication date: January 15, 2004Applicant: Novozymes Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Patent number: 6544774Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: GrantFiled: November 2, 2000Date of Patent: April 8, 2003Assignee: Novozymes Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Publication number: 20020146764Abstract: Novel methods and compositions are provided for enhanced yield of heterologous proteins in eucaryotic cells. The method and compositions involve employing fusion sequences involving a sequence encoding a heterologous product produced in relatively large amount as a stable polypeptide in the host fused to a second sequence in open reading frame with the prior sequence coding for a different heterologous polypeptide. In particular, a sequence coding for ubiquitin is joined to another polypeptide of interest providing for high yields of the fusion product.Type: ApplicationFiled: August 16, 2001Publication date: October 10, 2002Applicant: Chiron CorporationInventors: Lawrence S. Cousens, Patricia A. Tekamp-Olson, Jeffrey R. Shuster, James P. Merryweather
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Publication number: 20020028481Abstract: Novel methods and compositions are provided for enhanced yield of heterologous proteins in eucaryotic cells. The method and compositions involve employing fusion sequences involving a sequence encoding a heterologous product produced in relatively large amount as a stable polypeptide in the host fused to a second sequence in open reading frame with the prior sequence coding for a different heterologous polypeptide. In particular, a sequence coding for ubiquitin is joined to another polypeptide of interest providing for high yields of the fusion product.Type: ApplicationFiled: May 24, 1995Publication date: March 7, 2002Inventors: LAWRENCE S. COUSENS, PATRICIA A. TEKAMP-OLSON, JEFFREY R. SHUSTER, JAMES P. MERRYWEATHER
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Patent number: 6183985Abstract: A method is provided for expressing non-yeast proteins under the control of ADH2 regulatory sequences in a yeast host having enhanced expression of ADR I. Transformed yeast hosts are also provided.Type: GrantFiled: March 1, 1995Date of Patent: February 6, 2001Assignee: Chiron CorporationInventor: Jeffrey R. Shuster
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Patent number: 6184026Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: GrantFiled: September 24, 1999Date of Patent: February 6, 2001Assignee: Novo Nordisk Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Patent number: 6066493Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.Type: GrantFiled: March 13, 1997Date of Patent: May 23, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: Jeffrey R. Shuster, John C. Royer
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Patent number: 6060305Abstract: The present invention relates non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium host cells of the section Discolor or a teleomorph or synonym thereof, comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter.Type: GrantFiled: March 13, 1997Date of Patent: May 9, 2000Assignee: Novo Nordisk Biotech, Inc.Inventors: John C. Royer, Donna L. Moyer, Yoder T. Wendy, Jeffrey R. Shuster
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Patent number: 5843753Abstract: The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells comprising said nucleic acid fragments.Type: GrantFiled: March 3, 1995Date of Patent: December 1, 1998Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.Inventors: Jeffrey R. Shuster, Mark Madden, Donna L. Moyer, Claus Fuglsang, Sven Branner
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Patent number: 5837847Abstract: The invention is related to a non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium, e.g., Fusarium graminearum host cell comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter. The invention further relates to a method for the production of recombinant proteins using such Fusarium host cells. The invention also relates to a promoter and terminator sequence which may be used in such cells.Type: GrantFiled: August 29, 1997Date of Patent: November 17, 1998Assignee: Novo Nordisk Biotech, Inc.Inventors: John C. Royer, Donna L. Moyer, Yoder T. Wendy, Jeffrey R. Shuster