Abstract: Provided herein are compounds of formula (I) and formula (II) that are inhibitors of QPCTL and QPCT: Also provided are pharmaceutical compositions comprising the compounds, and methods for using the compounds for the treatment of disease.

Abstract: A device receives network segment information identifying network segments associated with a network, and receives endpoint host session information identifying sessions associated with endpoint hosts communicating with the network. The device generates, based on the network segment information and the endpoint host session information, a data structure that includes information associating the network segments with the sessions associated with the endpoint hosts. The device updates the data structure based on changes in the sessions associated with the endpoint hosts and based on changes in locations of the endpoint hosts within the network segments, and identifies, based on the data structure, a particular endpoint host, of the endpoint hosts, that changed locations within the network segments. The device determines a threat policy action to enforce for the particular endpoint host, and causes the threat policy action to be enforced, by the network, for the particular endpoint host.

Abstract: An electronic system, a method, and a computer program product generate an image stream with spherical background effects for multiple participants presented in a shared virtual venue during a video call. The method includes generating a composite image stream of the first foreground image superimposed at a first assigned location and a second foreground image superimposed at a second assigned location on a spherical background image. The method includes communicating the composite image stream to first and second electronic devices oriented to respective first and second vantage points associated with the first and second assigned locations of a virtual venue presented within the spherical background image. The method includes rotating the spherical background image relative to the first and the second vantage point presented to a respective display device of the first and the second electronic devices in relation to movement of a corresponding first participant and second participant.

Abstract: An electronic system, a method, and a computer program product generate a video recording or stream with a spherical background image that maintains orientation like a natural background as an image capturing device changes location or aim direction. The method includes determining a stationary orientation of a spherical background image in a virtual space geospatially aligned with a first physical location of an image capturing device. The method includes extracting a foreground image from an image stream of the field of view captured by the image capturing device. The method includes generating a composite image stream of a foreground image, which is extracted from an image stream from the image capturing device, superimposed on the spherical background image. In response to movement, the method includes updating a virtual orientation and/or a virtual location of the spherical background image to remain geospatially aligned with the first physical location.

Abstract: An apparatus comprising at least a processor, and a memory associated with the processor having computer coded instructions therein, wherein the computer coded instructions are configured to, when executed by the processor, cause the apparatus to perform acts comprising: receiving a first messaging communication associated with a communication platform; causing the first messaging communication to be rendered within a messaging pane in a communication interface of the communication platform; receiving a thread request to create a subsidiary thread communication; in response to receiving the thread request, generating and transmitting for display a thread summary indicator renderable within the messaging pane proximate the first messaging communication, wherein the thread summary indicator is configured to be selectable by a user with access to the first messaging communication; receiving an indication of an input indicating a selection of the thread summary indicator; and causing, based at least in part on re

Abstract: In some embodiments, a computer system applies a time of day setting to a virtual environment. In some embodiments, the time of day setting is updated based on an event. In some embodiments, a computer system displays content in an expanded display mode. In some embodiments, computer systems join a communication session while maintaining display of respective environments. In some embodiments, a computer system moves a portal based on user movement. In some embodiments, computer systems share a virtual environment. Computer systems can display media with simulated lighting. Computer systems can share an environment. In some embodiments, a computer system selects a position relative to content. A computer system can present representations of communication session participants based on content. A computer system can present user interfaces to control visual appearances of an environment including media. Computer systems can change an appearance of an environment based on environmental modes.

Abstract: In some embodiments, a computer system applies a time of day setting to a virtual environment. In some embodiments, the time of day setting is updated based on an event. In some embodiments, a computer system displays content in an expanded display mode. In some embodiments, computer systems join a communication session while maintaining display of respective environments. In some embodiments, a computer system moves a portal based on user movement. In some embodiments, computer systems share a virtual environment. Computer systems can display media with simulated lighting. Computer systems can share an environment. In some embodiments, a computer system selects a position relative to content. A computer system can present representations of communication session participants based on content. A computer system can present user interfaces to control visual appearances of an environment including media. Computer systems can change an appearance of an environment based on environmental modes.

Abstract: An electronic system, a method, and a computer program product generate a video recording or stream with spherical background effects for video generation with automatic gesture-control background positioning for a spatially constrained user. The method includes extracting a foreground image from an image stream of the field of view captured by the image capturing device. The method includes generating a composite image stream of the foreground image superimposed on the spherical background image. The method includes identifying, within the image stream, that the foreground image is in a physically constrained space defined by physical constraint(s) around at least a portion of a background of the foreground image. In response to identifying that the foreground image is in a physically constrained space, the method includes activating a gesture-controlled background repositioning feature of the electronic system to automatically rotate a spherical background image based on receipt of a gesture control input.

Abstract: An apparatus can include a display, a facial interface, and a connection between the display and facial interface. The display can at least translate or rotate relative to the facial interface via the connection.

Abstract: An electronic system, a method, and a computer program product generate a video recording or stream with a spherical background image that maintains orientation like a natural background for a video call as an image capturing device changes location or aim direction. The method includes connecting, by a communication subsystem of an electronic system, over a network to a video communication session with second electronic device(s). The method includes determining a stationary orientation of a spherical background image in a virtual space geospatially aligned with a first physical location of the electronic system. The method includes extracting a foreground image from an image stream from image capturing device(s). The method includes generating a composite image stream of the foreground image superimposed on the spherical background image. The method includes communicating the composite image stream to second electronic system(s) that participate in a video communication session.

Abstract: The subject matter of this specification can be embodied in, among other things, an internal combustion engine ignition system includes a voltage divider configured to be coupled to a primary transformer ignition coil connector, the voltage divider configured to reduce a voltage received from the primary transformer ignition coil to a controller voltage, a comparator circuit with an input coupled to an output of the voltage divider, and a controller configured to detect the voltage output of the voltage divider, detect the voltage output of a vehicle electric power supply, detect the voltage output of a comparator, and determine an estimated breakdown voltage of a spark plug based on the detected output voltage of the voltage divider and the detected voltage of the power supply.

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: Compositions and methods relating to paraoxonase fusion polypeptides are disclosed. In some aspects, the fusions are bispecific molecules that include a first biologically active polypeptide linked amino-terminal to a biologically active paraoxonase (e.g., human PON1 or a variant thereof), wherein the first biologically active polypeptide is a DNase, an RNase, a SOD1, a CTLA-4 extracellular domain, a CD40 extracellular domain, or a polypeptide that specifically binds and neutralizes an inflammatory cytokine. Bispecific fusions may further include a second biologically active polypeptide (e.g., a dimerizing domain or a domain that specifically binds to the neonatal Fc receptor (FcRn)) linked carboxyl-terminal to the first biologically active polypeptide and amino-terminal to the paraoxonase. In other aspects, a fusion polypeptide includes a biologically active paraoxonase linked carboxyl-terminal or amino-terminal to a dimerizing or FcRn-binding domain.

Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.

Abstract: A method optimizes a training of a machine learning system. A conflict detection system discovers a conflict between a first training data and a second training data for a machine learning system, where the first training data and the second training data are ground truths that describe a same type of entity, and where the first training data and the second training data have different labels. In response to discovering the conflict between the first training data and the second training data for the machine learning system, an oracle adjusts the different labels of the first training data and the second training data. The machine learning system is then trained using the first training data and the second training data with the adjusted labels.

Abstract: A method for performing an electrosurgical procedure using an electrosurgical instrument including an end effector is disclosed. The method comprises applying a bipolar energy to a target tissue grasped by the end effector in a tissue-feathering segment, applying an energy blend of the bipolar energy and a monopolar energy to the target tissue in a tissue-warming segment and a tissue-sealing segment following the tissue-warming segment, and discontinuing the bipolar energy but continuing to apply the monopolar energy to the target tissue in a tissue-cutting segment following the tissue-sealing segment.

Abstract: An insulated shipping container is provided for maintaining a substantially uniform internal temperature. The base, walls and lid of an outer box define an enclosure. An insulating body and an insulating cover are located within the enclosure and define an insulated cavity. A chamber having a plurality of chamber sides is configured to hold one or more payloads at the substantially uniform internal temperature. A temperature control material distribution structure is located within the insulated cavity for constraining motion of temperature control material units. The temperature control material distribution structure comprises at least one partitioned tray or trough. The at least one partitioned tray comprises a tray bottom; and a plurality of partition walls extending away from the tray bottom and defining a plurality of partition compartments.

Abstract: Disclosed are techniques that provide a “best” picture taken within a few seconds of the moment when a capture command is received (e.g., when the “shutter” button is pressed). In some situations, several still images are automatically (that is, without the user's input) captured. These images are compared to find a “best” image that is presented to the photographer for consideration. Video is also captured automatically and analyzed to see if there is an action scene or other motion content around the time of the capture command. If the analysis reveals anything interesting, then the video clip is presented to the photographer. The video clip may be cropped to match the still-capture scene and to remove transitory parts. Higher-precision horizon detection may be provided based on motion analysis and on pixel-data analysis.

Abstract: Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

Abstract: A surgical instrument for use with a robotic system that has a control unit and a shaft portion that includes an electrically conductive elongated member that is attached to a portion of the robotic system. The elongated member is configured to transmit control motions from the robotic system to an end effector.