Patents by Inventor Jeffrey Tsao

Jeffrey Tsao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240293582
    Abstract: This disclosure provides, for example, double stranded DNA (dsDNA) molecules comprising a chemically modified cytosine nucleotide. In some embodiments, the dsDNA molecules comprise a therapeutic payload sequence. In some embodiments, the dsDNA molecules are resistant to endonuclease digestion and/or resistant to immune sensor recognition, and supports expression of a therapeutic payload encoded in the dsDNA molecules. The disclosure also provides, for example, pharmaceutical compositions comprising dsDNA molecules comprising a chemically modified cytosine nucleotide.
    Type: Application
    Filed: February 16, 2024
    Publication date: September 5, 2024
    Inventors: Jacob Rosenblum Rubens, Eric Christopher Keen, Alexandra Rachael Sneider, Jeffrey Tsao, Camilo Ayala Breton, Carl Wayne Brown, III, Samuel Alves-Czachor, Edward Matthew Kennedy
  • Publication number: 20240285805
    Abstract: This disclosure provides, for example, double stranded DNA (dsDNA) molecules comprising a chemically modified uridine nucleotide. In some embodiments, the dsDNA molecules comprise a therapeutic payload sequence. In some embodiments, the dsDNA molecules are resistant to endonuclease digestion and/or resistant to immune sensor recognition, and supports expression of a therapeutic payload encoded in the dsDNA molecules. The disclosure also provides, for example, pharmaceutical compositions comprising dsDNA molecules comprising a chemically modified uridine nucleotide.
    Type: Application
    Filed: February 16, 2024
    Publication date: August 29, 2024
    Inventors: Jacob Rosenblum Rubens, Eric Christopher Keen, Alexandra Rachael Sneider, Jeffrey Tsao, Camilo Ayala Breton, Carl Wayne Brown, III, Samuel Alves-Czachor, Edward Matthew Kennedy
  • Patent number: 7418287
    Abstract: A method of dynamic magnetic resonance imaging comprising acquiring undersampled magnetic resonance signals for successive temporal time slots. In a space spanned by geometrical space and temporal frequency and on the basic of a priori information the aliased difference magnetic resonance data which are gained by subtracting for respective k-space sampling positions data of a baseline magnetic resonance image from the undersampled magnetic resonance signals are decomposed into difference data which essentially pertain to individual spatial positions at individual time slots.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: August 26, 2008
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Jeffrey Tsao, Klaas Paul Pruessmann, Peter Boesiger
  • Patent number: 7342397
    Abstract: A novel magnetic resonance imaging method is described, wherein undersampled magnetic resonance signals are acquired by a receiver antenna system having spatial sensitivity profiles and the image being reconstructed from the undersampled magnetic resonance signals and the spatial sensitivity profiles. The reconstruction of the image is provided by an optimization of a cost function which accounts for any of noise statistics, signal statistics, and the spatial response function, the latter of which is defined by the spatial signal response from the object to be imaged, separately for each individual pixel.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: March 11, 2008
    Assignee: Universitat Zurich and ETH Zürich
    Inventors: Klaas Pruessmann, Jeffrey Tsao
  • Patent number: 7330027
    Abstract: This invention describes the combination of SSFP, a method for accelerating data acquisition, and an eddy current compensation method. This synergistic combination allows acquisition of images with high signal-to-noise ratio, high image contrast, high spatial and temporal resolutions, and good immunity against system instabilities. k-t BLAST and k-t SENSE are the preferred method for accelerating data acquisition, since they allow high acceleration factors, but other methods such as parallel imaging and reduced field-of-view imaging are also applicable. Typical applications of this invention include cine 3D cardiac imaging, and 2D real-time cardiac imaging.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: February 12, 2008
    Assignee: Universitat Zurich
    Inventors: Sebastian Kozerke, Jeffrey Tsao, Peter Boesiger, Klaas Pruessmann
  • Publication number: 20060208730
    Abstract: This invention describes the combination of SSFP, a method for accelerating data acquisition, and an eddy current compensation method. This synergistic combination allows acquisition of images with high signal-to-noise ratio, high image contrast, high spatial and temporal resolutions, and good immunity against system instabilities. k-t BLAST and k-t SENSE are the preferred method for accelerating data acquisition, since they allow high acceleration factors, but other methods such as parallel imaging and reduced field-of-view imaging are also applicable. Typical applications of this invention include cine 3D cardiac imaging, and 2D real-time cardiac imaging.
    Type: Application
    Filed: June 24, 2004
    Publication date: September 21, 2006
    Applicant: ETH ZURICH
    Inventors: Sebastian Kozerke, Jeffrey Tsao, Peter Boesiger, Klaas Pruessmann
  • Publication number: 20060186941
    Abstract: A novel magnetic resonance imaging method is described, wherein undersampled magnetic resonance signals are acquired by a receiver antenna system having spatial sensitivity profiles and the image being reconstructed from the undersampled magnetic resonance signals and the spatial sensitivity profiles. The reconstruction of the image is provided by an optimization of a cost function which accounts for any of noise statistics, signal statistics, and the spatial response function, the latter of which is defined by the spatial signal response from the object to be imaged, separately for each individual pixel.
    Type: Application
    Filed: June 24, 2004
    Publication date: August 24, 2006
    Applicant: ETH ZURICH, ETH TRANSFER
    Inventors: Klaas Pruessmann, Jeffrey Tsao
  • Patent number: 7005853
    Abstract: Successive magnetic resonance images are reconstructed from the respective sets of magnetic resonance signals of the dynamic series on the basis of the identified distribution of likelihood of changes and optionally the static reference image. The magnetic resonance signals are acquired by way of a receiver antennae system having a spatial sensitivity profile and in an undersampled fashion and the successive magnetic resonance images are reconstructed optionally also on the basis of the spatial sensitivity profile.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: February 28, 2006
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Jeffrey Tsao, Klaas Paul Pruessmann, Peter Boesiger
  • Publication number: 20050192497
    Abstract: In SENSitivity Encoding (SENSE), the reconstructed images are susceptible to amplified noise and/or artifacts if the underlying matrix inversion procedure is ill-conditioned. In this work, we propose to firstly apply the conventional SENSE algorithm to obtain an initial estimate. This initial estimate undergoes filtering to improve the signal-to-noise ratio. Then, it is fed back to the reconstruction as a reference image to estimate the amount of aliasing that may arise from regularization. We derive the optimal regularized solution that minimizes the weighted sum of artifact and noise power.
    Type: Application
    Filed: May 12, 2003
    Publication date: September 1, 2005
    Inventors: Jeffrey Tsao, Klaas Pruessmann, Peter Boesiger
  • Publication number: 20050189942
    Abstract: Successive magnetic resonance images are reconstructed from the respective sets of magnetic resonance signals of the dynamic series on the basis of the identified distribution of likelihood of changes and optionally the static reference image. The magnetic resonance signals are acquired by way of a receiver antennae system having a spatial sensitivity profile and in an undersampled fashion and the successive magnetic resonance images are reconstructed optionally also on the basis of the spatial sensitivity profile.
    Type: Application
    Filed: May 9, 2003
    Publication date: September 1, 2005
    Inventors: Jeffrey Tsao, Klaas Pruessmann, Peter Boesiger
  • Publication number: 20050174113
    Abstract: A method of dynamic magnetic resonance imaging comprising acquiring undersampled magnetic resonance signels for successive temporal time slots. In a space spanned by geometrical space and temporal frequency and on the basic of a priori information the aliased difference magnetic resonance data which are gained by subtracting for respective k-space sampling positions data of a baseline magnetic resonance image from the undersampled magnetic resonance signals are decomposed into difference data which essentially pertain to individual spatial positions at individual time slots.
    Type: Application
    Filed: May 8, 2003
    Publication date: August 11, 2005
    Inventors: Jeffrey Tsao, Klaas Pruessmann, Peter Boesiger