Patents by Inventor Jenn-Tzong Chen

Jenn-Tzong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220227728
    Abstract: The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.
    Type: Application
    Filed: January 19, 2021
    Publication date: July 21, 2022
    Inventors: MING-HSIN LI, KAI-HUNG CHENG, SHENG-NAN LO, SHIH-WEI LO, YUAN-RUEI HUANG, JENN-TZONG CHEN
  • Patent number: 11247947
    Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: February 15, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
  • Publication number: 20210147315
    Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 20, 2021
    Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
  • Publication number: 20200239409
    Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 30, 2020
    Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
  • Patent number: 10059661
    Abstract: A [F-18]FEONM precursor is synthesized. 2-bromoethanol is added to further connect an atom of oxygen at an N terminal of the precursor. Four atoms of carbon can be further connected. Thus, better fat-solubility is obtained along with the increase in carbon. Positioning in brain imaging becomes better.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: August 28, 2018
    Assignee: INTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Shu-Hung Lin, Sheng-Po Huang, Show-Wen Liu, Cheng-Fang Hsu, Jenn-Tzong Chen, Shiou-Shiow Farn, Wuu-Jyh Lin, Chyng-Yann Shiue
  • Patent number: 9789207
    Abstract: A PET imaging agent is made, by at first, washing out fluoride ions (F-18) adhered on an ion exchange resin to a reaction vessel with potassium carbonate/Kryptofix 2.2.2 in acetonitrile-water. After processing the first azeotropic distillation with helium while water is removed, the temperature is cooled down. Then, acetonitrile is added to the reaction vessel to be heated up. After processing the second azeotropic distillation with helium while water is removed, the temperature is cooled down and excess water is extracted. A precursor is then added to the reaction vessel to be heated up for processing a fluorination reaction. The reaction mixture obtained after the fluorination reaction is cooled down to be flown through a solid-phase extraction column with waste drained into a waste tank. Then, ethanol is used to wash out a product, i.e. [F-18]FEONM, adsorbed by the column, to be collected in a collection vial.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: October 17, 2017
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Li-Yuan Huang, Yean-Hung Tu, Jenn-Tzong Chen, Chyng-Yann Shiue
  • Patent number: 9186423
    Abstract: A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: November 17, 2015
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Wuu-Jyh Lin, Shiou-Shiow Farn, Yean-Hung Tu, Li-Yuan Huang, Dow-Che Chen, Kuo-Yuan Chu, Mao-Hsung Chang, Ting-Shien Duh, Jenn-Tzong Chen, Chyng-Yann Shiue
  • Patent number: 9163054
    Abstract: The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 20, 2015
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Li-Yuan Huang, Yen-Hung Tu, Wen-Chin Su, Jenn-Tzong Chen, Ting-Shien Duh, Wuu-Jyh Lin
  • Patent number: 8986652
    Abstract: The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/?mol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 24, 2015
    Assignee: National Tsing Hua University
    Inventors: Chung-Shan Yu, Ho-Lien Huang, Chun-Nan Yeh, Wei-Yuan Lee, Kang-Wei Chang, Ying-Cheng Huang, Kun-Ju Lin, Ching-Shiuann Yang, Shu-Fan Tien, Wen-Chin Su, Jenn-Tzong Chen, Wuu-Jyh Lin, Shiou-Shiow Farn
  • Patent number: 8961931
    Abstract: A 18F-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: February 24, 2015
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council
    Inventors: Ting-Shien Duh, Wuu-Jyh Lin, Jenn-Tzong Chen, Li-Yuan Huang, Hsin-Ell Wang, Chuan-Lin Chen, Wen-Yi Chang, Hao-Wen Kao
  • Patent number: 8691789
    Abstract: A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [123I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [123I]-IaraU, which is distinguishable from [18F]-FLT marking 18F on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [123I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [123I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: April 8, 2014
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council
    Inventors: Jenn-Tzong Chen, Ho-Lien Huang, Jia-Rong Chen, Chung-Shan Yu, Wen-Chin Su, Ching-Shiuann Yang, Wuu-Jyh Lin
  • Publication number: 20140079633
    Abstract: The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/?mol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.
    Type: Application
    Filed: February 1, 2013
    Publication date: March 20, 2014
    Applicant: NATIONAL TSING HUA UNIVERSITY
    Inventors: Chung-Shan Yu, Ho-Lien Huang, Chun-Nan Yeh, Wei-Yuan Lee, Kang-Wei Chang, Ying-Cheng Huang, Kun-Ju Lin, Ching-Shiuann Yang, Shu-Fan Tien, Wen-Chin Su, Jenn-Tzong Chen, Wuu-Jyh Lin, Shiou-Shiow Farn
  • Publication number: 20140066614
    Abstract: A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [123I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [123I]-IaraU, which is distinguishable from [18F]-FLT marking 18F on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [123I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [123I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.
    Type: Application
    Filed: December 10, 2012
    Publication date: March 6, 2014
    Applicant: Atomic Energy Council-Institute of Nuclear Research
    Inventors: Jenn-Tzong Chen, Ho-Lien Huang, Jia-Rong Chen, Chung-Shan Yu, Wen-Chin Su, Ching-Shiuann Yang, Wuu-Jyh Lin
  • Patent number: 8647407
    Abstract: The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: February 11, 2014
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council
    Inventors: Wuu-Jyh Lin, Chien-Hsin Lu, Jenn-Tzong Chen, Sun-Rong Hwang, Ying-Chieh Wang
  • Publication number: 20130104697
    Abstract: The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 2, 2013
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Wuu-Jyh Lin, Chien-Hsin Lu, Jenn-Tzong Chen, Sun-Rong Hwang, Ying-Chieh Wang
  • Publication number: 20130072672
    Abstract: The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.
    Type: Application
    Filed: September 20, 2011
    Publication date: March 21, 2013
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Li-Yuan Huang, Yen-Hung Tu, Wen-Chin Su, Jenn-Tzong Chen, Ting-Shien Duh, Wuu-Jyh Lin
  • Publication number: 20120259102
    Abstract: A 18F-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 11, 2012
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Ting-Shien Duh, Wuu-Jyh Lin, Jenn-Tzong Chen, Li-Yuan Huang, Hsin-Ell Wang, Chuan-Lin Chen, Wen-Yi Chang, Hao-Wen Kao
  • Patent number: 8157998
    Abstract: Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: April 17, 2012
    Assignee: Atomic Energy Council—Institute of Nuclear Energy Research
    Inventors: Wuu-Jyh Lin, Jenn-Tzong Chen, Sun-Rong Huang, Ying-Ming Tsai, Jainn-Hsin Lu
  • Publication number: 20110214995
    Abstract: Disclosed is a method for making carrier-free radioactive isotopic gallium-67. Stable isotopic zinc-68 is turned into zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to a proton beam. A cyclotron is used to provide irradiation from 15 to 40 MeV. After the irradiation, the zinc-68 solid target is dissolved in concentrated acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. High concentrated hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 liquid and gallium-67 liquid are filtered and separated from the solution. Thus, pure gallium-67 liquid is produced. With a vaporizer, the gallium-67 liquid is vaporized and turned into radioactive isotopic gallium-67.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 8, 2011
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Sun-Rong Huang, Ying-Ming Tsai, Jainn-Hsin Lu, Jenn-Tzong Chen, Wuu-Jyh Lin
  • Publication number: 20110178325
    Abstract: Disclosed is an automatic process for synthesizing F-18-FDDNP. The automatic process includes a preparation subroutine and a synthesis subroutine. The automatic process is efficient and simple. That is, it can be used to produce a large amount of chemicals in a short period of time. Furthermore, it reduces the risk of human exposure to radiation.
    Type: Application
    Filed: January 18, 2010
    Publication date: July 21, 2011
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Kang-Wei Chang, Yen-Hung Tu, Shih-Ying Lee, Jenn-Tzong Chen, Chia-Chieh Chen, Wuu-Jyh Lin