Patents by Inventor Jennifer Ann Chaplin
Jennifer Ann Chaplin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8906663Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: GrantFiled: November 16, 2012Date of Patent: December 9, 2014Assignee: Verenium CorporationInventors: David Weiner, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay M. Short, Grace DeSantis, Mark Madden, Mark J. Burk, Dan E. Robertson
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Patent number: 8501451Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.Type: GrantFiled: September 21, 2011Date of Patent: August 6, 2013Assignee: Verenium CorporationInventors: David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson, Darcy Madden
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Patent number: 8334125Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: GrantFiled: June 27, 2011Date of Patent: December 18, 2012Assignee: Verenium CorporationInventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay Short, David Weiner, Mark Madden, Darcy Madden, legal representative, Mark Burk, Dan Robertson
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Publication number: 20120009633Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.Type: ApplicationFiled: September 21, 2011Publication date: January 12, 2012Applicant: Verenium CorporationInventors: Mark Madden, DARCY MADDEN, David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson
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Publication number: 20110263839Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: June 27, 2011Publication date: October 27, 2011Applicant: VERENIUM CORPORATIONInventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
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Patent number: 8034595Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.Type: GrantFiled: October 8, 2007Date of Patent: October 11, 2011Assignee: Verenium CorporationInventors: Mark Madden, David Weiner, Jennifer Ann Chaplin
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Patent number: 7993901Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: GrantFiled: December 2, 2009Date of Patent: August 9, 2011Assignee: Verenium CorporationInventors: Grace Desantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay Short, David Weiner, Mark Madden, Marcy Madden, legal representative, Mark Burk, Dan Robertson
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Publication number: 20100086986Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: December 2, 2009Publication date: April 8, 2010Applicant: VERENIUM CORPORATIONInventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
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Patent number: 7651849Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: GrantFiled: March 3, 2009Date of Patent: January 26, 2010Inventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay M. Short, David Paul Weiner, Mark Madden, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson
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Publication number: 20090176976Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: March 3, 2009Publication date: July 9, 2009Inventors: Grace DESANTIS, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Madden, Mark J. Burk, Dan E. Robertson, Darcy Madden
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Publication number: 20090162906Abstract: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.Type: ApplicationFiled: October 8, 2007Publication date: June 25, 2009Applicant: Verenium CorporationInventors: Mark MADDEN, David Paul Weiner, Jennifer Ann Chaplin
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Patent number: 7521216Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: GrantFiled: May 15, 2002Date of Patent: April 21, 2009Assignee: Verenium CorporationInventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson, Mark Madden
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Patent number: 7300775Abstract: In accordance with the present invention there are provided methods for producing enantiomerically pure ?-substituted carboxylic acids, such as, for example, ?-amino acids and ?-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an anmionium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the enantiomerically pure ?-substituted carboxylic acid, such as, for example, ?-amino acids and ?-hydroxy acids.Type: GrantFiled: December 28, 2000Date of Patent: November 27, 2007Assignee: Verenium CorporationInventors: Darcy Madden, legal representative, David Paul Weiner, Jennifer Ann Chaplin, Dan E. Robertson, Mark Madden, deceased
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Patent number: 7026144Abstract: A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein R1 represents an isopropanol group, an isopropyl group or an isopropylene group, includes the steps of: contacting the racemic mixture in a suitable organic solvent with an esterifying agent and a stereospecific enzyme which stereoselectively esterifies the —OH group of the desired stereoisomer, for a time sufficient to convert a desired percentage of the desired stereoisomer to a compound of formula (IV), wherein R1 is as defined above and R4 is an alkyl or an aryl group, to give a first reaction product including the compound of formula (IV), the organic solvent, the unconverted stereoisomers of the compound of formula (III), excess esterifying agent and by-products of the reaction; and separating the compound of formula (IV) from the first reaction product.Type: GrantFiled: June 11, 2001Date of Patent: April 11, 2006Assignee: CSIRInventors: Jennifer Ann Chaplin, Neil Stockenstrom Gardiner, Robin Kumar Mitra, Christopher John Parkinson, Madrie Portwig, Butana Andrew Mboniswa, Melanie Daryl Evans-Dickson, Dean Brady, Stephanus Francois Marais, Shavani Reddy
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Publication number: 20040058422Abstract: A process of separating a desired (−) stereoisomer which is selected from (−) menthol or an equivalent (−) compound where the isopropyl group is replaced with an isopropanol or an isopropylene group, from a starting material comprising: 40 to 100 m/m % of a mixture of (−)-menthol and (+)-menthol; up to 30 m/m % of a mixture of (−)-isomenthol and (+)-isomenthol; up to 20 m/m % of a mixture of (−)-neomenthol and (+)-neomenthol; and up to 10 m/m % of a mixture of (−)-neoisomenthol and (+)-neoisomenthol or an equivalent (+) mixture where the isopropyl group is replaced with an isopropanol or an isopropylene group, includes the steps of: contacting the starting material with an esterifying agent and a stereospecific enzyme which is a Pseudomonas lipase enzyme which stereoselectively esterifies the —OH group of the desired (−) steroisomer, for a time sufficient to convert a desired percentage of the desired (−) stereoisomer to a deType: ApplicationFiled: September 9, 2003Publication date: March 25, 2004Inventors: Jennifer Ann Chaplin, Neil Stockenstrom Gardiner, Robin Kumar Mitra, Christopher John Parkinson, Madrie Portwig, Butana Andrew Mboniswa, Melanie Daryle Evans-Dickson, Dean Brady, Stephanus Francois Marais, Shavani Reddy
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Publication number: 20040038419Abstract: In one aspect, invention relates to the field of monitoring chemical reactions and, in one aspect, provides methods and kits for detecting the presence of nitrites and/or cyanide. In one aspect, the invention provides methods and kits for assaying catalytic activity of a material, such as an enzyme, in a chemical or biochemical process, or assaying catalytic activity of a material in a biological sample, such as a whole cell.Type: ApplicationFiled: May 15, 2003Publication date: February 26, 2004Applicant: Diversa CorporationInventors: David Paul Weiner, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Grace DeSantis, Mark J. Burk, Jeffrey McQuaid, Justin Stege
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Publication number: 20040002147Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: September 9, 2002Publication date: January 1, 2004Inventors: Grace Desantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark J. Burk, Eric J. Mathur, Darcy Madden (Heir)
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Publication number: 20030153031Abstract: A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein R1 represents an isopropanol group, an isopropyl group or an isopropylene group, includes the steps of: contacting the racemic mixture in a suitable organic solvent with an esterifying agent and a stereospecific enzyme which stereoselectively esterifies the —OH group of the desired stereoisomer, for a time sufficient to convert a desired percentage of the desired stereoisomer to a compound of formula (IV), wherein R1 is as defined above and R4 is an alkyl or an aryl group, to give a first reaction product including the compound of formula (IV), the organic solvent, the unconverted stereoisomers of the compound of formula (III), excess esterifying agent and by-products of the reaction; and separating the compound of formula (IV) from the first reaction product. The process is of particular application for the production of (−)-menthol.Type: ApplicationFiled: March 27, 2003Publication date: August 14, 2003Inventors: Jennifer Ann Chaplin, Neil Stockenstrom Gardiner, Robin Kumar Mitra, Christopher John Parkinson, Madrie Portwig, Butana Andrew Mboniswa, Melanie Daryl Evans-Dickson, Dean Brady, Stephanus Francois Marais, Shavani Reddy
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Publication number: 20030124698Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.Type: ApplicationFiled: May 15, 2002Publication date: July 3, 2003Applicant: DIVERSA CorporationInventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Maddes, Darcy Madden, Mark J. Burk, Eric Mathur
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Publication number: 20020012974Abstract: In accordance with the present invention there are provided methods for producing enantiomerically pure &agr;-substituted carboxylic acids, such as, for example, &agr;-amino acids and &agr;-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.Type: ApplicationFiled: December 28, 2000Publication date: January 31, 2002Inventors: Mark Madden, David Paul Weiner, Jennifer Ann Chaplin