Patents by Inventor Jennifer Ludington

Jennifer Ludington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060167247
    Abstract: The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
    Type: Application
    Filed: December 7, 2005
    Publication date: July 27, 2006
    Inventors: Enrique Michelotti, Eric Springman, Duyan Nguyen, Rupa Shetty, Younghee Lee, Kristofer Moffett, Jennifer Ludington, Ted Fujimoto, Zenon Konteatis, Bin Liu, Frank Hollinger, Bruce Dorsey
  • Publication number: 20050222776
    Abstract: A method for characterizing a molecular fragment to collect data related to the fragment that allows its evaluation for drug discovery purposes. Starting with a two-dimensional model of the fragment, an initial three-dimensional model of the fragment is derived. Conformers of the fragment are identified. The conformers are then clustered, and a representative conformer is selected from each cluster. An ab initio or semi-empirical calculation and analysis is performed on one or more of the selected conformers. Each atom in the selected conformer is then assigned a type. The selected conformer is analyzed to determine if it is structurally symmetric. If so, the three-dimensional model of the fragment is adjusted to reflect the symmetry. The size of the fragment is calculated to allow geometric analysis of how the fragment physically fits with the protein and/or other fragments. The solvation energy of the fragment is calculated. The free energy curve for the fragment is calculated.
    Type: Application
    Filed: March 31, 2004
    Publication date: October 6, 2005
    Applicant: Locus Pharmaceuticals, Inc.
    Inventors: Jennifer Ludington, Ted Fujimoto, Frank Hollinger