Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.

Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.

Abstract: A computing device is described that receives an indication of a notification, and determines a priority level associated with the notification. The computing device determines, based at least in part on the priority level, content of the notification. Responsive to receiving an indication of a gesture detected at an input device, the computing device outputs, for display, a notification center graphical user interface that includes a graphical indication of the notification including the content of the notification.

Abstract: An electronic device operates including a method for interpreting user input within an electronic device, the method comprising steps of receiving a first character via a user input (105), concurrently displaying a plurality of modal interpretations associated with the first character (110), selecting one of the plurality of modal interpretations (115), and displaying one of a first character result in response to the selection of the one of the plurality of modal interpretations (120).

Abstract: A method performed by one or more processing devices includes receiving data indicative of dictated speech that has been spoken by a user during speech dictation; causing speech recognition to be performed on the data to obtain units of text; selecting a unit from the units, wherein the unit selected corresponds to a portion of the data received at a time that is more recent relative to times at which others of the units are received; and generating, based on an output of the speech recognition, data for a graphical user interface, that when rendered on a display device, causes the graphical user interface to display: a visual representation of the dictated speech, wherein the visual representation includes a visual indicator of the unit selected; and a control for performing dictation correction on the unit selected in real-time during the speech dictation.

Abstract: A computing device may output a graphical user interface for display at a presence-sensitive screen including an edit region and a graphical keyboard. The computing device may receive an indication of a gesture detected at a location of the presence-sensitive screen within the graphical keyboard. In response, the computing device may output for display at the presence-sensitive screen, a modified graphical user interface including a media insertion user interface with a plurality of media insertion options. The computing device may receive an indication of a selection of at least one media insertion option associated with a media item. The computing device may output for display at the presence-sensitive screen, an updated graphical user interface including the media item within the edit region.

Abstract: A computing device is described that outputs, for display, a graphical indication of a notification that includes selectable graphical elements that each indicate a respective optional action associated with the notification. Responsive to receiving an indication of an input that corresponds to a selection of one of the selectable graphical elements, the computing device executes the respective optional action indicated by the selected one of the selectable graphical elements.

Abstract: A computing device is described that receives an indication of a notification, and determines a priority level associated with the notification. The computing device determines, based at least in part on the priority level, content of the notification. Responsive to receiving an indication of a gesture detected at an input device, the computing device outputs, for display, a notification center graphical user interface that includes a graphical indication of the notification including the content of the notification.

Abstract: A computing device is described that outputs, for display, a graphical indication of a first notification and a graphical indication of a second notification. The first and second notifications each include a respective first content portion and a respective second content portion. The graphical indication of the first notification includes both the first content portion and the second content portion of the first notification. The graphical indication of the second notification includes only the first content portion of the second notification. The computing device receives an indication of an input to remove the first notification from display. Responsive to the input, the computing device ceases to output, for display, the graphical indication of the first notification and outputs, for display, the graphical indication of the second notification by including the second content portion of the second notification in addition to the first content portion of the second notification.

Abstract: The invention relates to quinoline derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

Abstract: The invention relates to naphthalene derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

Abstract: A portable electronic device (100,400) and user interface (425) are operated using a method including initiating entry of a content string; determining the most probable completion alternative or a content prediction using a personalized and learning database (430); displaying the most probable completion alternative or next content prediction; determining whether a user has accepted the most probable completion alternative or next content prediction; and adding the most probable completion alternative or next content prediction to the content string upon user acceptance.

Abstract: A portable electronic device (100,400) and user interface (425) are operated using a method including initiating entry of a content string; determining the most probable completion alternative or a content prediction using a personalized and learning database (430); displaying the most probable completion alternative or next content prediction; determining whether a user has accepted the most probable completion alternative or next content prediction; and adding the most probable completion alternative or next content prediction to the content string upon user acceptance.

Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Abstract: The invention relates to quinoline derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

Abstract: The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.

Abstract: The invention relates to pyrazolopyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

Abstract: The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.