Patents by Inventor Jerbrena C. Jacobs

Jerbrena C. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11324759
    Abstract: Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: May 10, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Steven M. Peckham, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 11234991
    Abstract: Assay methods for determining purity of a sample of a sterol are provided. These methods include providing an HPLC eluent including a sterol, other compounds related to the sterol and a mobile volatile phase; generating an aerosol of liquid droplets from the HPLC eluent; drying the liquid droplets to obtain residue particles of the sterol; contacting the residue particles of the sterol with an ion stream which applies a size-dependent electrical charge to each of the residue particles to generate an electrical signal and measuring the electrical signal to determine the purity of the sterol in the sample. The sterol can be OXY133 or OXY133 monohydrate.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: February 1, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 11219702
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: January 11, 2022
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20210338431
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.
    Type: Application
    Filed: July 16, 2021
    Publication date: November 4, 2021
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20210275726
    Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis (2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Robert Doyle
  • Publication number: 20210238218
    Abstract: Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner.
    Type: Application
    Filed: April 12, 2021
    Publication date: August 5, 2021
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello
  • Patent number: 11065123
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: July 20, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 11013831
    Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis(2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: May 25, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Robert Doyle
  • Patent number: 10975115
    Abstract: Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner. The oxysterols of the current application can be used in effective amounts to grow bone.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 13, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello
  • Patent number: 10898498
    Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: January 26, 2021
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David S. Scher, Benjamin T. Reves, Roger E. Harrington, Susan J. Drapeau, Jerbrena C. Jacobs
  • Publication number: 20200338092
    Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.
    Type: Application
    Filed: July 10, 2020
    Publication date: October 29, 2020
    Inventors: David S. Scher, Benjamin T. Reves, Roger E. Harrington, Susan J. Drapeau, Jerbrena C. Jacobs
  • Publication number: 20200330648
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20200323638
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 15, 2020
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20200261626
    Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis(2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.
    Type: Application
    Filed: February 20, 2019
    Publication date: August 20, 2020
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Robert Doyle
  • Patent number: 10736993
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 11, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20200246509
    Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth, the implant comprising: a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and an oxysterol in an amount of about 20 wt % to about 90 wt % of the implant. The implant has a high oxysterol load. Methods of making and use are further provided.
    Type: Application
    Filed: April 16, 2020
    Publication date: August 6, 2020
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 10729702
    Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: August 4, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: David S. Scher, Benjamin T. Reves, Roger E. Harrington, Susan J. Drapeau, Jerbrena C. Jacobs
  • Patent number: 10695182
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: June 30, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Susan J. Drapeau, Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20200188415
    Abstract: Assay methods for determining purity of a sample of a sterol are provided. These methods include providing an HPLC eluent including a sterol, other compounds related to the sterol and a mobile volatile phase; generating an aerosol of liquid droplets from the HPLC eluent; drying the liquid droplets to obtain residue particles of the sterol; contacting the residue particles of the sterol with an ion stream which applies a size-dependent electrical charge to each of the residue particles to generate an electrical signal and measuring the electrical signal to determine the purity of the sterol in the sample. The sterol can be OXY133 or OXY133 monohydrate.
    Type: Application
    Filed: February 24, 2020
    Publication date: June 18, 2020
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs
  • Publication number: 20200190134
    Abstract: Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 18, 2020
    Inventors: Roger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello