Patents by Inventor Jerome L. Moniot
Jerome L. Moniot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6515151Abstract: Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.Type: GrantFiled: June 13, 2000Date of Patent: February 4, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
-
Patent number: 6515170Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.Type: GrantFiled: April 26, 2001Date of Patent: February 4, 2003Assignee: Bristol-Myers Squibb Co.Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Thomas P. Tully, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, William J. Winter, Neal G. Anderson, David A. Lust, Gerard Crispino, Sushil K. Srivastava
-
Patent number: 6261810Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.Type: GrantFiled: August 31, 1999Date of Patent: July 17, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, David A. Lust, Sushil K. Srivastava
-
Patent number: 6162922Abstract: Disclosed is a process for preparing N-substituted heterocyclic derivatives and its salts using phase transfer catalysis.Type: GrantFiled: January 19, 1999Date of Patent: December 19, 2000Assignee: Bristol-Myers Squibb Co.Inventors: Neal G. Anderson, Rajendra P. Deshpande, Jerome L. Moniot
-
Patent number: 6162913Abstract: N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.Type: GrantFiled: July 8, 1999Date of Patent: December 19, 2000Assignee: Bristol-Myers Squibb Co.Inventors: Jerome L. Moniot, Sushil K. Srivastava, William J. Winter, John J. Venit, Shankar Swaminathan, Keith Ramig, Paul A. Jass, Mark D. Schwinden, John L. Dillon, Jr., Saibaba Racha, James Simpson, Chien-Kuang Chen, Shawn K. Pack
-
Patent number: 6090951Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.Type: GrantFiled: August 25, 1997Date of Patent: July 18, 2000Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
-
Patent number: 5973160Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.Type: GrantFiled: February 13, 1996Date of Patent: October 26, 1999Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
-
Patent number: 5808102Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.Type: GrantFiled: August 22, 1997Date of Patent: September 15, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
-
Patent number: 4704457Abstract: A compund having the formula ##STR1## can be prepared by coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to yield a compound having the formula ##STR4## and oxidizing that compound to yield the desired compound; wherein R is hydrogen or an amino protecting group;R.sub.1 is hydrogen, methly or ethyl;M.sup..sym. is an inorganic cation or a substituted ammonium ion; andM.sub.1.sup..sym. is hydrogen, an organic cation, or a substituted ammonium ion.Type: GrantFiled: June 21, 1982Date of Patent: November 3, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Jerome L. Moniot, Christopher M. Cimarusti, Rita T. Fox
-
Patent number: 4602092Abstract: A method is provided for preparing phosphinic acid prodrug intermediates which are useful in preparing phosphinic acid angiotensin-converting enzyme inhibitors which method includes the step of coupling a phosphonous acid or its ester of the structure ##STR1## wherein R is H or lower alkyl and R.sup.1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl, with an alkylating agent of the structure ##STR2## wherein Hal is Cl, Br or I, n is 0 or 1, R.sup.2 is H or lower alkyl, and Z is H, lower alkyl, --CO.sub.2 R.sup.3 (wherein R.sup.3 is H or lower alkyl), ##STR3## (wherein R.sup.4 is H, lower alkyl, aryl or arylalkyl), --CN, or ##STR4## (wherein R.sup.5 and R.sup.6 may be the same or different and are selected from the group consisting of H, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkylalkyl and at least one of R.sup.5 and R.sup.6 is other than H, or R.sup.5 and R.sup.Type: GrantFiled: January 22, 1985Date of Patent: July 22, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: John K. Thottathil, Jerome L. Moniot
-
Patent number: 4501901Abstract: A method is provided for making substituted prolines of the structure ##STR1## wherein X is lower alkyl or aryl, R is H, lower alkyl or an alkali metal and Z is an N-protecting group, which method includes the step of reacting a compound of the structure ##STR2## wherein Z and R are as defined above and Q is Br. tosyloxy or mesylate, with an organic copper lithium compound of the structureXYCuLiwherein X is as defined above and Y is lower alkyl, aryl or CN.Where X is phenyl, the corresponding 4-cyclohexyl compound may be produced by conventional hydrogenation techniques.The compounds produced are useful as intermediates in the preparation of phosphinic acid derivatives useful in the treatment of hypertension.Type: GrantFiled: September 19, 1983Date of Patent: February 26, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: John K. Thottathil, Jerome L. Moniot, David Floyd, Steven Brandt
-
Patent number: 4443374Abstract: Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to obtain a compound having the formula ##STR4## reacting that compound with 2-aminooxy-2-methylpropanoic acid, or a salt thereof, to obtain a compound having the formula ##STR5## and, if R is an amino protecting group, deprotecting that compound to yield the desired product; whereinR is hydrogen or an amino protecting group;R.sub.1 is hydrogen, methyl or ethyl;M.sup..sym. is an inorganic cation or a substituted ammonium ion; andM.sub.1.sup..sym. is hydrogen, an inorganic cation or a substituted ammonium ion.Type: GrantFiled: February 1, 1982Date of Patent: April 17, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Christopher M. Cimarusti, Rita T. Fox, Alan W. Fritz, William H. Koster, Jerome L. Moniot
-
Patent number: 4424376Abstract: A method is provided for preparing intermediates for use in prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by reacting same with cyclopentendione, subjecting the resulting chiral ester intermediate to a fluorination and reduction to form the corresponding chiral ester diol intermediate, subjecting the diol to solvolysis to form the chiral triol intermediate, hydroxylating the chiral triol to form a pentol intermediate, subjecting the pentol to a ring cleavage to form the difluoro dihydroxy prostacyclin intermediate ##STR1## and subjecting same to a Witting reaction to form the difluoro dihydroxy prostacyclin intermediate ##STR2## All of the above-mentioned intermediates are novel compounds and thus are also provided.Type: GrantFiled: September 23, 1982Date of Patent: January 3, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Jerome L. Moniot, Rita T. Fox, Peter W. Sprague, Martin F. Haslanger
-
Patent number: 4362872Abstract: A method is provided for preparing intermediates for use in prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by reacting same with cyclopentendione, subjecting the resulting chiral ester intermediate to a fluorination and reduction to form the corresponding chiral ester diol intermediate, subjecting the diol to solvolysis to form the chiral triol intermediate, hydroxylating the chiral triol to form a pentol intermediate, subjecting the pentol to a ring cleavage to form the difluoro dihydroxy prostacyclin intermediate: ##STR1## and subjecting same to a Wittig reaction to form the difluoro dihydroxy prostacyclin intermediate: ##STR2## All of the above-mentioned intermediates are novel compounds and thus are also provided.Type: GrantFiled: September 24, 1981Date of Patent: December 7, 1982Assignee: E. R. Squibb & Sons, Inc.Inventors: Jerome L. Moniot, Rita T. Fox, Peter W. Sprague, Martin F. Haslanger
-
Patent number: 4326076Abstract: A method is provided for preparing the optically active isomer [2R-[2.alpha.,3.alpha.,5(R*)]]-2,2'-[[5-[3-[(1,1-dimethylethyl)amino]-2-hy droxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediyl]bis(oxy)]bis-[N,N-dipr opylacetamide] having the structure ##STR1## which is useful as an antiarrhythmic agent.Type: GrantFiled: October 9, 1980Date of Patent: April 20, 1982Assignee: E. R. Squibb & Sons, Inc.Inventors: Jerome L. Moniot, Rita T. Fox, Francis A. Sowinski
-
Patent number: 4311644Abstract: A method is provided for preparing intermediates for use in 10,10-difluoro prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by reacting same with cyclopentendione, subjecting the resulting chiral ester intermediate to a fluorination and reduction to form the corresponding chiral ester diol intermediate, subjecting the diol to solvolysis to form the chiral triol intermediate, hydroxylating the chiral triol to form a pentol intermediate, subjecting the pentol to a ring cleavage to form the difluoro dihydroxy prostacyclin intermediate ##STR1## and subjecting same to a Wittig reaction to form the difluoro dihydroxy prostacyclin intermediate ##STR2## All of the above-mentioned intermediates are novel compounds and thus are also provided.Type: GrantFiled: January 30, 1981Date of Patent: January 19, 1982Assignee: E. R. Squibb & Sons, Inc.Inventors: Jerome L. Moniot, Rita T. Fox, Peter W. Sprague, Martin F. Haslanger
-
Patent number: 4087426Abstract: Berberine and protoberberine analogs thereof are oxidatively dimerized in the presence of a base. Treatment of the dimer with alkanolic anhydrous acid yields the corresponding 8-alkoxyberberine (or protoberberine) phenol betaine which, in turn, may be converted to alpha and beta hydrastine.Type: GrantFiled: August 16, 1976Date of Patent: May 2, 1978Assignee: Research CorporationInventors: Maurice Shamma, Jerome L. Moniot